Compound

16alpha,17beta-estriol 16-O-(beta-D-glucuronate)

A steroid glucuronide anion that is the conjugate base of estriol 16-O-(β-D-glucuronide) arising from deprotonation of the carboxylic acid function; major species at pH 7.3.

Definition from ChEBI (CHEBI:136650), read 2026-09-23. CC BY 4.0.

CHEBI:136650ChEBI

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Structure

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A generated conformer of 16alpha,17beta-estriol 16-O-(beta-D-glucuronate) — one low-energy arrangement PubChem computed, not a measured structure. Hydrogens are not drawn; the formula counts them.

Class: Organic compound, anion
Formula: C24H31O9
Mass: 463.503 g/mol
Charge: -1
InChIKey: FQYGGFDZJFIDPU-JRSYHJKYSA-M
SMILES: [H][C@@]12CCc3cc(O)ccc3[C@@]1([H])CC[C@]1(C)[C@@H](O)[C@H](O[C@@H]3O[C@H](C(=O)[O-])[C@@H](O)[C@H](O)[C@H]3O)C[C@@]21[H]
Look it up: ChEBI PubChem By InChIKey

Identity from ChEBI, geometry from PubChem. Not evidence.

What it touches on the way

Mechanistic reach

3 entities

3 entities reached.

0 reported hops3 assembled from the scaffold

What the reference databases state

Statements

4 statements

4 statements · 2 reference databases · Subject: 16alpha,17beta-estriol 16-O-(beta-D-glucuronate) · Sources: Human-GEM, Rhea

Order

16alpha,17beta-estriol is converted to 16alpha,17beta-estriol 16-O-(beta-D-glucuronate)CompoundHuman-GEM MAR07984Inferred only
16alpha,17beta-estriol 16-O-(beta-D-glucuronate) is metabolised by UGT2B7ProteinRhea RHEA:52472Inferred only
16alpha,17beta-estriol 16-O-(beta-D-glucuronate) is a substrate of CHST10ProteinRhea RHEA:68672Inferred only
16alpha,17beta-estriol 16-O-(beta-D-glucuronate) is transported by ABCC1ProteinHuman-GEM MAR07986Inferred only

Reactions

7 reactions

16alpha,17beta-estriol+UDP-alpha-D-glucuronate16alpha,17beta-estriol 16-O-(beta-D-glucuronate)+UDP
Catalysed by UGT2B28 or UGT2B4 or UGT1A1 or UGT1A8 or UGT1A10
Reaction pageLeft to rightBalancedEC 2.4.1.17GO:0005783
Human-GEM MAR07984CC BY 4.0Reference data
16alpha,17beta-estriol 16-O-(beta-D-glucuronate)16alpha,17beta-estriol 16-O-(beta-D-glucuronate)
Reaction pageReversibleBalancedGO:0005829, GO:0005783
Human-GEM MAR07985CC BY 4.0Reference data
16alpha,17beta-estriol 16-O-(beta-D-glucuronate)+ATP+water16alpha,17beta-estriol 16-O-(beta-D-glucuronate)+ADP+proton+phosphate(3-)
Transported by ABCC1
Reaction pageLeft to rightBalancedGO:0005829, GO:0005615
Human-GEM MAR07986CC BY 4.0Reference data
16alpha,17beta-estriol 16-O-(beta-D-glucuronate)
Reaction pageReversibleBalance undeterminableGO:0005615
Human-GEM MAR09315CC BY 4.0Reference data
16alpha,17beta-estriol+UDP-alpha-D-glucuronate16alpha,17beta-estriol 16-O-(beta-D-glucuronate)+UDP+hydron
Catalysed by UGT2B7
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:52472CC BY 4.0Reference data
16alpha,17beta-estriol 16-O-(beta-D-glucuronate)+3'-phosphoadenylyl sulfate16alpha,17beta-estriol 16-O-(3-sulfo-beta-D-glucuronate)+adenosine 3',5'-bisphosphate+hydron
Catalysed by CHST10
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:68672CC BY 4.0Reference data
16alpha,17beta-estriol 16-O-(beta-D-glucuronate)+ATP(4-)+water16alpha,17beta-estriol 16-O-(beta-D-glucuronate)+ADP(3-)+hydrogenphosphate+hydron
Transported by ABCC2
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:86863CC BY 4.0Reference data

Other names

4 names

Resolves to: 16alpha,17beta-estriol 16-O-(beta-D-glucuronate)

Also called: 16alpha,17beta-estriol 16-O-(beta-D-glucuronide)(1-)16α,17β-estriol 16-O-(β-D-glucuronide)(1−)
Systematic name: 3,17beta-dihydroxyestra-1,3,5(10)-trien-16alpha-yl beta-D-glucopyranosiduronate3,17β-dihydroxyestra-1,3,5(10)-trien-16α-yl β-D-glucopyranosiduronate