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Catalyst

knowcompoundspterostilbene

Specimen compound organic compoundPlate I

Pterostilbene

Nested hairline contours trace the electron density of one computed shape of pterostilbene, teal at the edge warming to amber over the atoms.
fig. 1Pterostilbene · electron density · PubChem CID 5281727, computed 3D conformer
Formula
C16H16O3
Molar mass
256.301 g/mol
ChEBI
CHEBI:8630
PubChem CID
5281727
InChIKey
VLEUZFDZJKSGMX-ONEGZZNKSA-N

↓ lowered 2 findings in 2 endpoints · – no difference found 7 in 7

01 · the evidence, ordered

What the evidence says

Strong
0
Moderate
9
Limited
0
Very limited
0
Insufficient
0

How to read these marks

Fig. 2 Pterostilbene CHEBI:8630 9 endpoints 9 findings
×1.60
Labels
CompoundInspector

Pterostilbene

Most findings

  • Alanine aminotransferase×1
  • Aspartate aminotransferase×1
  • Diastolic blood pressure×1
  • Gamma-glutamyl transferase×1
Show the remaining 5Show the first 4
  • Serum creatinine concentration×1
  • Serum potassium concentration×1
  • Serum sodium concentration×1
  • Serum uric acid×1
  • Systolic blood pressure×1

36 compounds on the outer ring, not drawn

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  1. Alanine aminotransferase
  2. Aspartate aminotransferase
  3. Diastolic blood pressure
  4. Gamma-glutamyl transferase
  5. Serum creatinine concentration
  6. Serum potassium concentration
  7. Serum sodium concentration
  8. Serum uric acid
  9. Systolic blood pressure
Show the remaining 1Show the first 8
fig. 3 · 9 endpoints · 9 findingsno endpoint contested

02 · findings

What pterostilbene moved, and by how much

  • Dose studied: as its paper gave it.
  • Evidence strength: computed from the study. How it is computed
  • Industry funding: named on its row.
Direction

9 shown

  1. Diastolic blood pressureMoved: lowersEvidence: ModeratePaper: PMID 250572762014Industry funded
    Who
    Adults with hypercholesterolemia; high-dose arm only (pterostilbene 125 mg twice daily) against matching placebo, 6-8 weeks
    Dose studied
    pterostilbene 125 mg orally twice daily

    There was a significant reduction versus placebo in SBP and DBP with high dose pterostilbene (see Figure 2).”

    Quoted verbatim from Pterostilbene on metabolic parameters: a randomized, double-blind, and placebo-controlled trial.RCTPermalink
  2. Serum potassium concentrationMoved: no difference foundEvidence: ModeratePaper: PMID 376714862023
    Who
    Healthy adults aged 18-49 years (PME n = 29 analysed, placebo n = 30); 60 days
    Dose studied
    PME (Silbinol), P. marsupium heartwood extract standardised to 90% pterostilbene, 100 mg capsule twice daily (200 mg/day) after meals

    Renal function parameters like urea, uric acid, creatinine, glomerular filtration rate, sodium, potassium, and chloride levels were comparable between placebo and PME at all time points (Table 4 and Table S5, S6).”

    Quoted verbatim from A Short-Term Safety Evaluation of Silbinol®- an Extract from Pterocarpus marsupium in Healthy Adults- a Randomized, Double-Blind, Placebo-Controlled Study.RCT · 2 monthsPermalink
  3. Serum uric acidMoved: no difference foundEvidence: ModeratePaper: PMID 376714862023
    Who
    Healthy adults aged 18-49 years (PME n = 29 analysed, placebo n = 30); 60 days
    Dose studied
    PME (Silbinol), P. marsupium heartwood extract standardised to 90% pterostilbene, 100 mg capsule twice daily (200 mg/day) after meals

    Renal function parameters like urea, uric acid, creatinine, glomerular filtration rate, sodium, potassium, and chloride levels were comparable between placebo and PME at all time points (Table 4 and Table S5, S6).”

    Quoted verbatim from A Short-Term Safety Evaluation of Silbinol®- an Extract from Pterocarpus marsupium in Healthy Adults- a Randomized, Double-Blind, Placebo-Controlled Study.RCT · 2 monthsPermalink
  4. Systolic blood pressureMoved: lowersEvidence: ModeratePaper: PMID 250572762014Industry funded
    Who
    Adults with hypercholesterolemia; high-dose arm only (pterostilbene 125 mg twice daily) against matching placebo, 6-8 weeks
    Dose studied
    pterostilbene 125 mg orally twice daily

    There was a significant reduction versus placebo in SBP and DBP with high dose pterostilbene (see Figure 2).”

    Quoted verbatim from Pterostilbene on metabolic parameters: a randomized, double-blind, and placebo-controlled trial.RCTPermalink
  5. Serum creatinine concentrationMoved: no difference foundEvidence: ModeratePaper: PMID 376714862023
    Who
    Healthy adults aged 18-49 years (PME n = 29 analysed, placebo n = 30); 60 days
    Dose studied
    PME (Silbinol), P. marsupium heartwood extract standardised to 90% pterostilbene, 100 mg capsule twice daily (200 mg/day) after meals

    Renal function parameters like urea, uric acid, creatinine, glomerular filtration rate, sodium, potassium, and chloride levels were comparable between placebo and PME at all time points (Table 4 and Table S5, S6).”

    Quoted verbatim from A Short-Term Safety Evaluation of Silbinol®- an Extract from Pterocarpus marsupium in Healthy Adults- a Randomized, Double-Blind, Placebo-Controlled Study.RCT · 2 monthsPermalink
  6. Serum sodium concentrationMoved: no difference foundEvidence: ModeratePaper: PMID 376714862023
    Who
    Healthy adults aged 18-49 years (PME n = 29 analysed, placebo n = 30); 60 days
    Dose studied
    PME (Silbinol), P. marsupium heartwood extract standardised to 90% pterostilbene, 100 mg capsule twice daily (200 mg/day) after meals

    Renal function parameters like urea, uric acid, creatinine, glomerular filtration rate, sodium, potassium, and chloride levels were comparable between placebo and PME at all time points (Table 4 and Table S5, S6).”

    Quoted verbatim from A Short-Term Safety Evaluation of Silbinol®- an Extract from Pterocarpus marsupium in Healthy Adults- a Randomized, Double-Blind, Placebo-Controlled Study.RCT · 2 monthsPermalink
  7. Alanine aminotransferaseMoved: no difference foundEvidence: ModeratePaper: PMID 376714862023
    Who
    Healthy adults aged 18-49 years (PME n = 29 analysed, placebo n = 30); 60 days
    Dose studied
    PME (Silbinol), P. marsupium heartwood extract standardised to 90% pterostilbene, 100 mg capsule twice daily (200 mg/day) after meals

    Parameters of liver function such as total bilirubin, Aspartate transaminase (AST), Alanine transaminase (ALT), and Gamma-glutamyltransferase (GGT) were within the standard reference ranges in subjects supplemented with PME, comparable to the placebo group at the screening, day30 and final visit.”

    Quoted verbatim from A Short-Term Safety Evaluation of Silbinol®- an Extract from Pterocarpus marsupium in Healthy Adults- a Randomized, Double-Blind, Placebo-Controlled Study.RCT · 2 monthsPermalink
  8. Aspartate aminotransferaseMoved: no difference foundEvidence: ModeratePaper: PMID 376714862023
    Who
    Healthy adults aged 18-49 years (PME n = 29 analysed, placebo n = 30); 60 days
    Dose studied
    PME (Silbinol), P. marsupium heartwood extract standardised to 90% pterostilbene, 100 mg capsule twice daily (200 mg/day) after meals

    Parameters of liver function such as total bilirubin, Aspartate transaminase (AST), Alanine transaminase (ALT), and Gamma-glutamyltransferase (GGT) were within the standard reference ranges in subjects supplemented with PME, comparable to the placebo group at the screening, day30 and final visit.”

    Quoted verbatim from A Short-Term Safety Evaluation of Silbinol®- an Extract from Pterocarpus marsupium in Healthy Adults- a Randomized, Double-Blind, Placebo-Controlled Study.RCT · 2 monthsPermalink
  9. Gamma-glutamyl transferaseMoved: no difference foundEvidence: ModeratePaper: PMID 376714862023
    Who
    Healthy adults aged 18-49 years (PME n = 29 analysed, placebo n = 30); 60 days
    Dose studied
    PME (Silbinol), P. marsupium heartwood extract standardised to 90% pterostilbene, 100 mg capsule twice daily (200 mg/day) after meals

    Parameters of liver function such as total bilirubin, Aspartate transaminase (AST), Alanine transaminase (ALT), and Gamma-glutamyltransferase (GGT) were within the standard reference ranges in subjects supplemented with PME, comparable to the placebo group at the screening, day30 and final visit.”

    Quoted verbatim from A Short-Term Safety Evaluation of Silbinol®- an Extract from Pterocarpus marsupium in Healthy Adults- a Randomized, Double-Blind, Placebo-Controlled Study.RCT · 2 monthsPermalink

No dose is advised.

  • Dose studied: as its paper gave it.
  • Evidence strength: computed from the study. How it is computed
  • Industry funding: named on its row.

03 · identity

Structure

fig. 4Pterostilbene · 2D structure · ChEBI’s SMILES
Charge
0
SMILES
COc1cc(/C=C/c2ccc(O)cc2)cc(OC)c1

04 · on the label · 227 products

Labelled products

Source: NIH DSLD · Ingredient: pterostilbene · 227 products · Declared amount per serving: 0.02–300 mg

143 labels state an amount84 do not

  • AbsonutrixPterostilbeneEthanol · suspended in water and ethanol300 mgper 0.59 mLDSLD:322369
  • Absorb HealthPterostilbene 100 mg100 mgper 1 capsuleDSLD:216045
  • AJS NutritionAJS Brain Pro 20Pterocarpus marsupium · equivalent to 300 mg of raw Pterostilbene powder (Vijayasar)30 mgper 3 capsulesDSLD:329285
  • Alive By NatureNAD+ / AMPK ActivatorDimethylresveratrolamount not statedper 2 vegetarian capsulesDSLD:230806
  • AN Amazing Nutrition Amazing FormulasPterostilbene 100 mg100 mgper 1 capsuleDSLD:251648
  • Applied NutritionBB Skinamount not statedper 2 liquid soft-gelsDSLD:64207
  • AptogenixDetox Assist20 mgper 2 capsulesDSLD:323744
  • BioSchwartzNootropic Brain Boost10 mgper 1 capsuleDSLD:249903
  • BiotiviaPtero MaxPterostilbene, 99%100 mgper 1 vegetarian capsuleDSLD:58351
  • BiotiviaPteroActivPterostilbene 98%, 98% Extract yields250 mgper 1 capsuleDSLD:33056
  • BluScienceHeart BluPterostilbene, pTeroPure(R50 mgper 1 vegetarian capsuleDSLD:1591
  • Bronson LaboratoriesPtero-B50 mgper 1 capsuleDSLD:25472
Show the remaining 215Show the first 12
Every product, as data

Label record: NIH Office of Dietary Supplements · CC0

05 · the record

Sources

5

papers screened for pterostilbene

admitted
2
read and discarded
3
not read yet
0

The screening record, every paper and why

Documented interactions
None reported

Sources cited

2 papers · 9 findings

Show every paper citedHide the papers cited
165Endpoints measured, not recorded as findingsEvery row, on one page
20Papers indexed under pterostilbene