Endpoint
Erythrocyte glutathione reductase activation coefficient (EGRac)
CAT:outcome/egrac-riboflavin-statusreported in activation coefficient (dimensionless ratio)1 finding from 1 compound
What moved it
How to read these marks1 finding · 1 compound · by evidence strength
| Compound | Direction | Findings | Strongest evidence |
|---|---|---|---|
| riboflavin | down | 1 | Evidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers. |
Reported to move it
1 finding
riboflavin — decreases
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Finding“Riboflavin supplementation significantly decreased plasma tHcy (P=0.005) and EGRAC (P=0.014), but not plasma ferritin, uric acid or C-reactive protein.”
Quoted verbatim from Riboflavin supplementation and biomarkers of cardiovascular disease in the elderly.. - Study
- RCT
- Participants
- 42
- Duration
- 4 weeks
- Dose
- 10 mg riboflavin per day orally vs placebo
- Population
- Portuguese elderly people aged 60-94 years with low riboflavin status (EGRAC of 1.2 or more) attending day social centres
Riboflavin supplementation and biomarkers of cardiovascular disease in the elderly.2009PMID:19390751Permalink
How it is measured
Erythrocyte glutathione reductase activation coefficient (EGRac), a functional biomarker of riboflavin (vitamin B2) status computed as the ratio of erythrocyte glutathione reductase enzymatic activity measured with added flavin adenine dinucleotide (FAD) cofactor to activity measured without it, in a red-cell haemolysate.
Measured, not recorded
- Subject
- erythrocyte glutathione reductase activation coefficient (egrac)
- Measurements
- 1 measurement
- Recorded as a finding
- No
Show what was measured
erythrocyte glutathione reductase activation coefficient (EGRAC)
decreases, p = 0.014, n = 42
Riboflavin supplementation significantly decreased plasma tHcy (P=0.005) and EGRAC (P=0.014), but not plasma ferritin, uric acid or C-reactive protein
PMID:19390751 · one of two readings recorded this
Sources cited
1 paper
- Subject
- erythrocyte glutathione reductase activation coefficient (egrac)
- Findings
- 1
- Papers
- 1