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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReachWhat a compound can become

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PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
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OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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A reference for what the literature reports. Not medical advice.

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Index

Regulatory assessments

Names from LiverTox (NIH)

regulatory assessments in the graph: 46
linked to a studied compound: 24

By LiverTox category

Category A12
Category C4
Category D6
Category E24

Filter regulatory assessments by name

All 46, grouped by LiverTox category

Category AWell known cause of liver injury

12 assessments

AndrostenedioneCategoryALiverToxWell known, well described and well reported to cause liver injury.
CocaineCategoryALiverToxWell known, well described and well reported to cause liver injury.At high doses only
EstradiolCategoryALiverTox

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Evidence: Compounds · Outcomes · Papers · Search

Well known, well described and well reported to cause liver injury.

EstriolCategoryALiverToxWell known, well described and well reported to cause liver injury.

EstroneCategoryALiverToxWell known, well described and well reported to cause liver injury.

HydroxyprogesteroneCategoryALiverToxWell known, well described and well reported to cause liver injury.

IronCategoryALiverToxWell known, well described and well reported to cause liver injury.Linked to a studied compoundAt high doses only

MercaptopurineCategoryALiverToxWell known, well described and well reported to cause liver injury.

NiacinCategoryALiverToxWell known, well described and well reported to cause liver injury.Linked to a studied compoundAt high doses only

ProgesteroneCategoryALiverToxWell known, well described and well reported to cause liver injury.

ThioguanineCategoryALiverToxWell known, well described and well reported to cause liver injury.

Vitamin ACategoryALiverToxWell known, well described and well reported to cause liver injury.Linked to a studied compoundAt high doses only

Category CProbable cause of liver injury

4 assessments

AldesleukinCategoryCLiverToxProbably linked to idiosyncratic liver injury, reported uncommonly.At high doses only
CandesartanCategoryCLiverToxProbably linked to idiosyncratic liver injury, reported uncommonly.
LosartanCategoryCLiverToxProbably linked to idiosyncratic liver injury, reported uncommonly.
ThyroxineCategoryCLiverToxProbably linked to idiosyncratic liver injury, reported uncommonly.

Category DPossible cause of liver injury

6 assessments

AcyclovirCategoryDLiverToxA possible hepatotoxin, single-to-few case reports.
Chondroitin SulfateCategoryDLiverToxA possible hepatotoxin, single-to-few case reports.Linked to a studied compound
CysteamineCategoryDLiverToxA possible hepatotoxin, single-to-few case reports.At high doses only
GlucosamineCategoryDLiverToxA possible hepatotoxin, single-to-few case reports.Linked to a studied compound
MycophenolateCategoryDLiverToxA possible hepatotoxin, single-to-few case reports.
ValacyclovirCategoryDLiverToxA possible hepatotoxin, single-to-few case reports.

Category EUnlikely cause of liver injury

24 assessments

Ascorbic acidCategoryELiverToxDespite extensive use, no evidence that the agent has caused liver injury.Linked to a studied compound
Bee PollenCategoryELiverToxDespite extensive use, no evidence that the agent has caused liver injury.
BerberineCategoryELiverToxDespite extensive use, no evidence that the agent has caused liver injury.Linked to a studied compound
BetaineCategoryELiverToxDespite extensive use, no evidence that the agent has caused liver injury.Linked to a studied compound
BiotinCategoryELiverToxDespite extensive use, no evidence that the agent has caused liver injury.Linked to a studied compound
CaffeineCategoryELiverToxDespite extensive use, no evidence that the agent has caused liver injury.Linked to a studied compound
CalcitriolCategoryELiverToxDespite extensive use, no evidence that the agent has caused liver injury.
CholineCategoryELiverToxDespite extensive use, no evidence that the agent has caused liver injury.Linked to a studied compound
Coenzyme Q10CategoryELiverToxDespite extensive use, no evidence that the agent has caused liver injury.Linked to a studied compound
CyanocobalaminCategoryELiverToxDespite extensive use, no evidence that the agent has caused liver injury.Linked to a studied compound
HydrocortisoneCategoryELiverToxDespite extensive use, no evidence that the agent has caused liver injury.
IodineCategoryELiverToxDespite extensive use, no evidence that the agent has caused liver injury.
L-GlutamineCategoryELiverToxDespite extensive use, no evidence that the agent has caused liver injury.Linked to a studied compound
MagnesiumCategoryELiverToxDespite extensive use, no evidence that the agent has caused liver injury.Linked to a studied compound
MelatoninCategoryELiverToxDespite extensive use, no evidence that the agent has caused liver injury.Linked to a studied compound
NiacinamideCategoryELiverToxDespite extensive use, no evidence that the agent has caused liver injury.Linked to a studied compound
NitroglycerinCategoryELiverToxDespite extensive use, no evidence that the agent has caused liver injury.
QuercetinCategoryELiverToxDespite extensive use, no evidence that the agent has caused liver injury.Linked to a studied compound
ResveratrolCategoryELiverToxDespite extensive use, no evidence that the agent has caused liver injury.Linked to a studied compound
RiboflavinCategoryELiverToxDespite extensive use, no evidence that the agent has caused liver injury.Linked to a studied compound
Sodium BenzoateCategoryELiverToxDespite extensive use, no evidence that the agent has caused liver injury.Linked to a studied compound
TestosteroneCategoryELiverToxDespite extensive use, no evidence that the agent has caused liver injury.Linked to a studied compound
ThiamineCategoryELiverToxDespite extensive use, no evidence that the agent has caused liver injury.Linked to a studied compound
Vitamin CCategoryELiverToxDespite extensive use, no evidence that the agent has caused liver injury.Linked to a studied compound