Compound
(2-hydroxyphenyl)acetic acid
A hydroxy monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is substituted by a 2-hydroxyphenyl group. It is a metabolite of phenylalanine and is excreted in the urine of patients suffering from diseases like phenylketonuria.
Definition from ChEBI (CHEBI:28478), read 2026-09-23. CC BY 4.0.
What it touches on the way
Mechanistic reach
1 entity
1 entities reached.
0 reported hops1 assembled from the scaffold
What the reference databases state
Chemical structure
- (2-hydroxyphenyl)acetic acid has the functional parent acetic acidCompoundChEBI CHEBI:28478Inferred only
Statements
2 statements
2 statements · 1 reference database · Subject: (2-hydroxyphenyl)acetic acid · Sources: Human-GEM
- 3-phenylpyruvate is converted to (2-hydroxyphenyl)acetic acidCompoundHuman-GEM MAR06726Inferred only
- (2-hydroxyphenyl)acetic acid is transported by SLC16A1ProteinHuman-GEM MAR11780Inferred only
Reactions
5 reactions
dioxygen+3-phenylpyruvate(2-hydroxyphenyl)acetic acid+carbon dioxide
Catalysed by HPD
Reaction pageLeft to rightBalancedEC 1.13.11.27GO:0005829
Human-GEM MAR06726CC BY 4.0Reference data
Reaction pageReversibleBalance undeterminableGO:0005615
Human-GEM MAR11440CC BY 4.0Reference data
(2-hydroxyphenyl)acetic acid+proton(2-hydroxyphenyl)acetic acid+proton
Transported by SLC16A1
Reaction pageReversibleBalancedEC 7.6.2.2GO:0005829, GO:0005615
Human-GEM MAR11780CC BY 4.0Reference data
3-phenylpyruvate+dioxygen(2-hydroxyphenyl)acetic acid+carbon dioxide
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:31107CC BY 4.0Reference data
CHEBI:18401+reduced [NADPH--hemoprotein reductase]+dioxygen(2-hydroxyphenyl)acetic acid+oxidized [NADPH--hemoprotein reductase]+water+hydron
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:53392CC BY 4.0Reference data
Where it reaches
8 systems, 14 regions, 21 tissues, 21 transporter routes — routes, not measurements: transporters known to carry (2-hydroxyphenyl)acetic acid are expressed there, and no source reports it arriving.
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Other names
5 names
Resolves to: (2-hydroxyphenyl)acetic acid
- Also called
- (o-hydroxyphenyl)acetic acid2-hydroxybenzeneacetic acid2-hydroxyphenylacetic acid2'-hydroxyphenylacetic acido-hydroxyphenylacetic acid