Compound
nitric oxide
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from arginine by nitric oxide synthase. Nitric oxide is one of the endothelium-dependent relaxing factors released by the vascular endothelium and mediates vasodilation. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic guanylate cyclase and thus elevates intracellular levels of cyclic GMP.
Structure
No three-dimensional record for this entry.
- Class
- Inorganic compound
- Formula
- NO
- Mass
- 30.006 g/mol
- Charge
- 0
- InChIKey
- MWUXSHHQAYIFBG-UHFFFAOYSA-N
- SMILES
- [N]=O
- Look it up
- ChEBIBy InChIKey
Identity from ChEBI. Not evidence.
What it touches on the way
Mechanistic reach
4 entities
4 entities reached.
0 reported hops4 assembled from the scaffold
- AQP1ProteinUNIPROT:P29972transported byInferred only126 paths122 endpoints
- nitrateCompoundCHEBI:17632converted toInferred only66 paths17 endpoints
- CPProteinUNIPROT:P00450substrate ofInferred only25 paths25 endpoints
- CYGBProteinUNIPROT:Q8WWM9substrate ofInferred only5 paths5 endpoints
What the reference databases state
Statements
8 statements
8 statements · 1 reference database · Subject: nitric oxide · Sources: Rhea
- nitrate is converted to nitric oxideCompoundRhea RHEA:19469Inferred only
- nitric oxide is converted to nitrateCompoundRhea RHEA:19469Inferred only
- nitric oxide is converted to nitrateCompoundRhea RHEA:19465Inferred only
- nitrate is converted to nitric oxideCompoundRhea RHEA:19465Inferred only
- nitric oxide is converted to nitriteCompoundRhea RHEA:78539Inferred only
- nitric oxide is a substrate of CPProteinRhea RHEA:78539Inferred only
- nitric oxide is a substrate of CYGBProteinRhea RHEA:78091Inferred only
- nitric oxide is transported by AQP1ProteinRhea RHEA:74895Inferred only
Reactions
30 reactions
L-arginine+2NADPH(4-)+2dioxygenL-citrulline+2water+2NADP(3-)+nitric oxide
Catalysed by NOS2 or NOS1 or NOS3
Reaction pageLeft to rightUnbalancedEC 1.14.13.39cytosol
Human-GEM MAR02023CC BY 4.0Reference data
2N(5)-[(Z)-amino(hydroxyimino)methyl]ornithine+NADPH(4-)+2dioxygen2L-citrulline+proton+2water+NADP(3-)+2nitric oxide
Catalysed by NOS2 or NOS1 or NOS3
Reaction pageLeft to rightBalancedEC 1.14.13.39cytosol
Human-GEM MAR03993CC BY 4.0Reference data
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR05009CC BY 4.0Reference data
Reaction pageReversibleBalance undeterminableextracellular space
Human-GEM MAR09381CC BY 4.0Reference data
CHEBI:17045+water2CHEBI:10545+2nitric oxide+2hydron
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:10988CC BY 4.0Reference data
nitric oxide+Fe(III)-[cytochrome c]+waterFe(II)-[cytochrome c]+nitrite+2hydron
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:15233CC BY 4.0Reference data
2nitric oxide+NADPH(4-)+2dioxygen2nitrate+NADP(3-)+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:19465CC BY 4.0Reference data
2nitric oxide+NADH(2-)+2dioxygen2nitrate+NAD(1-)+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:19469CC BY 4.0Reference data
2L-arginine+3NADPH(4-)+4dioxygen+hydron2L-citrulline+2nitric oxide+3NADP(3-)+4water
Catalysed by NOS3 or NOS1 or NOS2
Reaction pageLeft to rightBalanced
Rhea RHEA:19897CC BY 4.0Reference data
2N(omega)-hydroxy-L-arginine+NADPH(4-)+2dioxygen2L-citrulline+2nitric oxide+NADP(3-)+2water+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:24664CC BY 4.0Reference data
CHEBI:17045+NAD(1-)+water2nitric oxide+NADH(2-)+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:29607CC BY 4.0Reference data
CHEBI:17045+NADP(3-)+water2nitric oxide+NADPH(4-)+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:29611CC BY 4.0Reference data
On the label
Labelled products
1 product
Source: NIH DSLD · Ingredient: nitric oxide · 1 product · Declared amount per serving: 500–500 mg (1 products)
1 label states an amount0 do not
- Musclegen Performance NutritionAmino Hyper Cell Strawberry FlavorL-Arginine Alpha-Ketoglutarate500 mgper 15 mLDSLD:213495
Label record: NIH Office of Dietary Supplements · CC0
Where it reaches
10 systems, 25 regions, 112 tissues, 112 transporter routes — routes, not measurements: transporters known to carry nitric oxide are expressed there, and no source reports it arriving.
Loading the model…
Other names
17 names
Resolves to: nitric oxide
- Also called
- (.)NO(NO)(.)(NO)•[NO]•NOEDRFendothelium-derived relaxing factormononitrogen monoxidenitrogen monooxidenitrogen monoxidenitrosylNONO(.)NO•
- Systematic name
- oxidonitrogen(.)oxidonitrogen(•)oxoazanyl