Endpoint
Wound infection incidence
Invasion of a wound by pathogenic microorganisms.
CAT:outcome/wound-infection-incidencereported in risk ratio4 findings from 2 compounds
What moved it
How to read these marks4 findings · 2 compounds · by evidence strength
| Compound | Direction | Findings | Strongest evidence |
|---|---|---|---|
| triclosan | down | 3 | Evidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers. |
| L-glutamine | down | 1 | Evidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence. |
Reported to move it
4 findings
triclosan — decreases
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Findingreplicated ×2“The risk of developing SSI was significantly reduced in the triclosan group compared with the standard suture group (RR 0.73, 95% CI 0.65 to 0.82).”
Quoted verbatim from The use of triclosan-coated sutures to prevent surgical site infections: a systematic review and meta-analysis of the literature.. - Study
- meta-analysis
- Population
- Surgical patients across 25 RCTs (clean to dirty surgery) closed with triclosan-coated versus standard sutures
Effect 0.73 risk ratio, 95% CI 0.65 to 0.82
The use of triclosan-coated sutures to prevent surgical site infections: a systematic review and meta-analysis of the literature.2019PMID:31481559Permalink
triclosan — decreases
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Findingreplicated ×2“According to the meta-analysis, the overall incidence of SSI was statistically significantly lower with the use of triclosan-coated sutures compared to uncoated sutures, 14.8% vs. 17.3% respectively, OR 0.84 (95% CI [0.75,0.93], p = 0.001),.”
Quoted verbatim from Systematic review and meta-analysis comparing surgical site infection in abdominal surgery between triclosan-coated and uncoated sutures.. - Study
- meta-analysis
- Population
- Adults undergoing open or laparoscopic abdominal surgery with fascial closure by triclosan-coated versus uncoated polydioxanone or polyglactin 910 sutures (11 RCTs)
Effect 0.84 odds ratio, 95% CI 0.75 to 0.93
Systematic review and meta-analysis comparing surgical site infection in abdominal surgery between triclosan-coated and uncoated sutures.2024PMID:38713430An author is affiliated with a producerPermalink
L-glutamine — decreases
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“Moreover, glutamine supplement reduced wound infection (risk ratios [RR] = 0.38, 95% CI 0.21 to 0.69, I2 = 0%, 3 trials), but not nonwound infection (RR = 0.88, 95% CI 0.73 to 1.05, I2 = 39.6%, 9 trials).”
Quoted verbatim from Glutamine Supplementation on Burn Patients: A Systematic Review and Meta-analysis.. - Study
- meta-analysis
- Population
- Burn patients receiving glutamine supplementation (meta-analysis of 3 trials); route not stated.
Glutamine Supplementation on Burn Patients: A Systematic Review and Meta-analysis.2024PMID:38243579Permalink
triclosan — decreases
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Findingreplicated ×2“This SLR and meta-analysis showed that the use of triclosan antimicrobial sutures reduced the incidence of SSI after clean, clean-contaminated, and contaminated surgery.”
Quoted verbatim from Meta-analysis of prevention of surgical site infections following incision closure with triclosan-coated sutures: robustness to new evidence.. - Study
- meta-analysis
- Population
- Surgical patients undergoing clean, clean-contaminated and contaminated surgery, pooled from 15 RCTs
Meta-analysis of prevention of surgical site infections following incision closure with triclosan-coated sutures: robustness to new evidence.2014PMID:24738988Permalink
How it is measured
Proportion of patients developing a clinically or microbiologically diagnosed infection at the burn wound, surgical wound, or graft site, per the source's stated diagnostic criteria. The diagnostic criteria and the follow-up window are recorded with each finding.
Measured, not recorded
- Subject
- wound infection incidence
- Measurements
- 1 measurement
- Recorded as a finding
- No
Show what was measured
Wound infection incidence
RR=0.42, 95% CI 0.16-1.06, p = 0.07, n = 81
The pooled data indicated that enteral Gln tend to reduce the incidence of wound infection, but is not significant (RR = 0.42; 95% CI: 0.16 − 1.06; p = 0.070) with no heterogeneity (I 2 = 0%; p = 0.680).
PMID:37460347 · one of two readings recorded this
Sources cited
4 papers
- Subject
- wound infection incidence
- Findings
- 4
- Papers
- 4
Glutamine Supplementation on Burn Patients: A Systematic Review and Meta-analysis.record2024PMID:382435791 finding
Systematic review and meta-analysis comparing surgical site infection in abdominal surgery between triclosan-coated and uncoated sutures.record2024PMID:387134301 finding
The use of triclosan-coated sutures to prevent surgical site infections: a systematic review and meta-analysis of the literature.record2019PMID:314815591 finding
Meta-analysis of prevention of surgical site infections following incision closure with triclosan-coated sutures: robustness to new evidence.record2014PMID:247389881 finding