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ReactionsRhea and Human-GEM, by subsystem
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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Compound

hexacosanoate

The conjugate base of cerotic acid.

Definition from ChEBI (CHEBI:31013), read 2026-09-23. CC BY 4.0.

CHEBI:31013ChEBI

Open in the graph

Structure

2D depiction

No three-dimensional record for this entry.

Class: Organic compound, anion
Formula: C26H51O2
Mass: 395.692 g/mol
Charge: -1
InChIKey: XMHIUKTWLZUKEX-UHFFFAOYSA-M
SMILES: CCCCCCCCCCCCCCCCCCCCCCCCCC(=O)[O-]
Look it up: ChEBI By InChIKey

Identity from ChEBI. Not evidence.

What it touches on the way

Inferred

Not reported; assembled from reference reactions.

Mechanistic reach

22 entities

22 entities reached.

0 reported hops22 assembled from the scaffold

CD36ProteinUNIPROT:P16671transported byInferred only164 paths77 endpoints
FABP5ProteinUNIPROT:Q01469transported byInferred only101 paths93 endpoints
ACSL1ProteinUNIPROT:P33121substrate ofInferred only66 paths33 endpoints
ACSL3ProteinUNIPROT:O95573substrate ofInferred only58 paths29 endpoints
ABCA1ProteinUNIPROT:O95477transported byInferred only47 paths47 endpoints
ACSL4ProteinUNIPROT:O60488substrate ofInferred only46 paths23 endpoints
SLC27A2ProteinUNIPROT:O14975substrate ofInferred only44 paths22 endpoints
SLC27A3ProteinUNIPROT:Q5K4L6transported byInferred only24 paths24 endpoints
ACSL6ProteinUNIPROT:Q9UKU0substrate ofInferred only22 paths11 endpoints
ACSL5ProteinUNIPROT:Q9ULC5substrate ofInferred only22 paths11 endpoints
CYP4F2ProteinUNIPROT:P78329metabolized byInferred only18 paths18 endpoints
CYP4F3ProteinUNIPROT:Q08477metabolized byInferred only16 paths16 endpoints

Show the remaining 10

SLC27A5ProteinUNIPROT:Q9Y2P5substrate ofInferred only15 paths15 endpoints
ACSBG1ProteinUNIPROT:Q96GR2substrate ofInferred only14 paths7 endpoints
ACSBG2ProteinUNIPROT:Q5FVE4substrate ofInferred only12 paths6 endpoints
FABP3ProteinUNIPROT:P05413transported byInferred only9 paths9 endpoints
ABCD1ProteinUNIPROT:P33897transported byInferred only7 paths7 endpoints
FABP4ProteinUNIPROT:P15090transported byInferred only6 paths6 endpoints
SLC27A6ProteinUNIPROT:Q9Y2P4transported byInferred only4 paths4 endpoints
FABP1ProteinUNIPROT:P07148transported byInferred only3 paths3 endpoints
SLC27A4ProteinUNIPROT:Q6P1M0transported byInferred only2 paths2 endpoints
FABP2ProteinUNIPROT:P12104transported byInferred only1 path1 endpoint

What the reference databases state

Statements

38 statements

38 statements · 2 reference databases · Subject: hexacosanoate · Sources: Human-GEM, Rhea

Search this listOrder

hexacosanoate is converted to hexacosanoyl-CoACompoundRhea RHEA:43748Inferred only
hexacosanoyl-CoA is converted to hexacosanoateCompoundRhea RHEA:40791Inferred only
hexacosanoate is metabolised by CYP4F2ProteinRhea RHEA:40083Inferred only
hexacosanoate is metabolised by CYP4F3ProteinRhea RHEA:40083Inferred only
hexacosanoate is a substrate of ACSBG1ProteinHuman-GEM MAR00341Inferred only
hexacosanoate is a substrate of ACSBG1ProteinHuman-GEM MAR02979Inferred only
hexacosanoate is a substrate of ACSBG2ProteinHuman-GEM MAR00341Inferred only
hexacosanoate is a substrate of ACSBG2ProteinHuman-GEM MAR02979Inferred only
hexacosanoate is a substrate of ACSL1ProteinHuman-GEM MAR00341Inferred only
hexacosanoate is a substrate of ACSL1ProteinHuman-GEM MAR02979Inferred only
hexacosanoate is a substrate of ACSL3ProteinHuman-GEM MAR00341Inferred only
hexacosanoate is a substrate of ACSL3ProteinHuman-GEM MAR02979Inferred only

Show the remaining 26

hexacosanoate is a substrate of ACSL4ProteinHuman-GEM MAR02979Inferred only
hexacosanoate is a substrate of ACSL4ProteinHuman-GEM MAR00341Inferred only
hexacosanoate is a substrate of ACSL5ProteinHuman-GEM MAR00341Inferred only
hexacosanoate is a substrate of ACSL5ProteinHuman-GEM MAR02979Inferred only
hexacosanoate is a substrate of ACSL6ProteinHuman-GEM MAR02979Inferred only
hexacosanoate is a substrate of ACSL6ProteinHuman-GEM MAR00341Inferred only
hexacosanoate is a substrate of SLC27A2ProteinHuman-GEM MAR00341Inferred only
hexacosanoate is a substrate of SLC27A2ProteinHuman-GEM MAR02979Inferred only
hexacosanoate is a substrate of SLC27A5ProteinRhea RHEA:43748Inferred only
hexacosanoate is transported by ABCA1ProteinHuman-GEM MAR00343Inferred only
hexacosanoate is transported by ABCD1ProteinRhea RHEA:67084Inferred only
hexacosanoate is transported by CD36ProteinHuman-GEM MAR00340Inferred only
hexacosanoate is transported by CD36ProteinRhea RHEA:86479Inferred only
hexacosanoate is transported by FABP1ProteinHuman-GEM MAR00340Inferred only
hexacosanoate is transported by FABP12ProteinHuman-GEM MAR00340Inferred only
hexacosanoate is transported by FABP2ProteinHuman-GEM MAR00340Inferred only
hexacosanoate is transported by FABP3ProteinHuman-GEM MAR00340Inferred only
hexacosanoate is transported by FABP4ProteinHuman-GEM MAR00340Inferred only
hexacosanoate is transported by FABP5ProteinHuman-GEM MAR00340Inferred only
hexacosanoate is transported by FABP6ProteinHuman-GEM MAR00340Inferred only
hexacosanoate is transported by FABP7ProteinHuman-GEM MAR00340Inferred only
hexacosanoate is transported by FABP9ProteinHuman-GEM MAR00340Inferred only
hexacosanoate is transported by SLC27A1ProteinHuman-GEM MAR00340Inferred only
hexacosanoate is transported by SLC27A3ProteinHuman-GEM MAR00340Inferred only
hexacosanoate is transported by SLC27A4ProteinHuman-GEM MAR00340Inferred only
hexacosanoate is transported by SLC27A6ProteinHuman-GEM MAR00340Inferred only

Reactions

30 reactions

fatty acid0.0001MAM00003e+0.0001(11Z,14Z)-eicosadienoate+0.0001MAM00010e+0.0001MAM00017e+0.0001MAM00019e+0.0001MAM00021e+0.0001MAM00094e+0.0001MAM00104e+0.0001MAM00111e+0.0001MAM00114e+0.0001MAM00115e+0.0001MAM00117e+0.0001MAM00128e+0.0001MAM00132e+0.0001MAM00135e+0.0001MAM00260e+0.0001MAM00265e+0.0001MAM00315e+0.0001MAM00341e+0.0001MAM01197e+0.0001MAM01207e+0.0001MAM01235e+0.0001MAM01238e+0.0001(7Z,10Z,13Z,16Z)-docosatetraenoate+0.0082(5Z,8Z,11Z,14Z)-eicosatetraenoate+0.0001docosanoate+0.0001hexacosanoate+0.0001MAM01582e+0.0001MAM01583e+0.0001(11Z)-eicosenoate+0.0001MAM01585e+0.0041all-cis-docosa-4,7,10,13,16,19-hexaenoic acid+0.002(8Z,11Z,14Z)-eicosatrienoate+0.0001(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate+0.0001eicosanoate+0.0001elaidic acid+0.001(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate+0.0001MAM01932e+0.0001MAM02053e+0.0001dodecanoate+0.0001tetracosanoate+0.1535linoleic acid+0.0092alpha-linolenic acid+0.0001MAM02456e+0.0001(5Z,8Z,11Z)-eicosatrienoate+0.0338tetradecanoate+0.0001(15Z)-tetracosenoate+0.0001MAM02613e+0.3837(9Z)-octadecenoate+0.0001MAM02648e+0.3015hexadecanoic acid+0.0522(9Z)-hexadecenoate+0.0001MAM02690e+0.0001MAM02745e+0.046octadecanoate+0.0001MAM02939e+0.0001tricosanoate+0.0001MAM03051e+0.0001(17Z)-hexacosenoate
Reaction pageLeft to rightBalance undeterminableextracellular space
Human-GEM MAR00012CC BY 4.0Reference data
MAM02560e0.0048MAM00003e+0.0016(11Z,14Z)-eicosadienoate+0.0016MAM00010e+0.0001MAM00017e+0.0001MAM00019e+0.0001MAM00021e+0.0001MAM00094e+0.0001MAM00104e+0.0001MAM00111e+0.0001MAM00114e+0.0001MAM00115e+0.0001MAM00117e+0.0001MAM00128e+0.0001MAM00132e+0.0001MAM00135e+0.0001MAM00260e+0.0001MAM00265e+0.0001MAM00315e+0.0001MAM00341e+0.0001MAM01197e+0.0001MAM01207e+0.0001MAM01235e+0.0001MAM01238e+0.0017(7Z,10Z,13Z,16Z)-docosatetraenoate+0.0137(5Z,8Z,11Z,14Z)-eicosatetraenoate+0.0007docosanoate+0.0005hexacosanoate+0.0001MAM01582e+0.0002MAM01583e+0.0001(11Z)-eicosenoate+0.0001MAM01585e+0.0046all-cis-docosa-4,7,10,13,16,19-hexaenoic acid+0.0025(8Z,11Z,14Z)-eicosatrienoate+0.0019(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate+0.0011eicosanoate+0.0001elaidic acid+0.002(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate+0.0048MAM01932e+0.0001MAM02053e+0.0034dodecanoate+0.0012tetracosanoate+0.071linoleic acid+0.0005alpha-linolenic acid+0.0056MAM02456e+0.0005(5Z,8Z,11Z)-eicosatrienoate+0.0283tetradecanoate+0.0003(15Z)-tetracosenoate+0.0001MAM02613e+0.3746(9Z)-octadecenoate+0.0001MAM02648e+0.2949hexadecanoic acid+0.0686(9Z)-hexadecenoate+0.003MAM02690e+0.0001MAM02745e+0.1031octadecanoate+0.0001MAM02939e+0.0002tricosanoate+0.0001MAM03051e+0.0001(17Z)-hexacosenoate
Reaction pageLeft to rightBalance undeterminableextracellular space
Human-GEM MAR00015CC BY 4.0Reference data
0.0001MAM00003e+0.0023(11Z,14Z)-eicosadienoate+0.0003MAM00010e+0.0002MAM00017e+0.003MAM00019e+0.0001MAM00021e+0.0001MAM00094e+0.0001MAM00104e+0.0001MAM00111e+0.0001MAM00114e+0.0001MAM00115e+0.0004MAM00117e+0.0023MAM00128e+0.0001MAM00132e+0.0001MAM00135e+0.0001MAM00260e+0.0001MAM00265e+0.0001MAM00315e+0.0001MAM00341e+0.0045MAM01197e+0.0002MAM01207e+0.001MAM01235e+0.0037MAM01238e+0.0008(7Z,10Z,13Z,16Z)-docosatetraenoate+0.0051(5Z,8Z,11Z,14Z)-eicosatetraenoate+0.0002docosanoate+0.0001hexacosanoate+0.0001MAM01582e+0.0002MAM01583e+0.0046(11Z)-eicosenoate+0.0204MAM01585e+0.0012all-cis-docosa-4,7,10,13,16,19-hexaenoic acid+0.0021(8Z,11Z,14Z)-eicosatrienoate+0.0009(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate+0.0009eicosanoate+0.0001elaidic acid+0.0009(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate+0.0005MAM01932e+0.0001MAM02053e+0.0061dodecanoate+0.0001tetracosanoate+0.1573linoleic acid+0.0073alpha-linolenic acid+0.0001MAM02456e+0.0001(5Z,8Z,11Z)-eicosatrienoate+0.035tetradecanoate+0.0001(15Z)-tetracosenoate+0.0001MAM02613e+0.383(9Z)-octadecenoate+0.0004MAM02648e+0.2478hexadecanoic acid+0.0395(9Z)-hexadecenoate+0.0039MAM02690e+0.0001MAM02745e+0.0613octadecanoate+0.0001MAM02939e+0.0001tricosanoate+0.0001MAM03051e+0.0001(17Z)-hexacosenoateMAM02561e
Reaction pageLeft to rightBalance undeterminableextracellular space
Human-GEM MAR00016CC BY 4.0Reference data
hexacosanoatehexacosanoate
Transported by SLC27A6 or FABP3 or SLC27A1 or CD36 or SLC27A3 or FABP2 or FABP1 or FABP7 or FABP5 or SLC27A4 or FABP6 or FABP4 and 2 more alternatives
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR00340CC BY 4.0Reference data
ATP+hexacosanoate+CHEBI:1146900AMP+hexacosanoyl-CoA+diphosphate(3-)
Catalysed by ACSL4 or ACSBG1 or ACSL3 or ACSBG2 or SLC27A2 or ACSL1 or ACSL6 or ACSL5
Reaction pageLeft to rightBalancedEC 6.2.1.3cytosol
Human-GEM MAR00341CC BY 4.0Reference data
water+hexacosanoyl-CoAhexacosanoate+CHEBI:1146900+proton
Catalysed by BAAT or ACOT6
Reaction pageLeft to rightBalancedEC 3.1.2.2cytosol
Human-GEM MAR00342CC BY 4.0Reference data
ATP+hexacosanoate+waterADP+hexacosanoate+proton+phosphate(3-)
Transported by ABCA1
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR00343CC BY 4.0Reference data
hexacosanoate
Reaction pageReversibleBalance undeterminableextracellular space
Human-GEM MAR00618CC BY 4.0Reference data
fatty acid0.0001MAM00003c+0.0001(11Z,14Z)-eicosadienoate+0.0001MAM00010c+0.0001MAM00017c+0.0001MAM00019c+0.0001MAM00021c+0.0001MAM00094c+0.0001MAM00104c+0.0001MAM00111c+0.0001MAM00114c+0.0001MAM00115c+0.0001MAM00117c+0.0001MAM00128c+0.0001MAM00132c+0.0001MAM00135c+0.0001MAM00260c+0.0001MAM00265c+0.0001MAM00315c+0.0001MAM00341c+0.0001MAM01197c+0.0001MAM01207c+0.0001MAM01235c+0.0001MAM01238c+0.0001(7Z,10Z,13Z,16Z)-docosatetraenoate+0.0024(5Z,8Z,11Z,14Z)-eicosatetraenoate+0.0001docosanoate+0.0001hexacosanoate+0.0001MAM01582c+0.0001MAM01583c+0.0001(11Z)-eicosenoate+0.0208MAM01585c+0.0005all-cis-docosa-4,7,10,13,16,19-hexaenoic acid+0.0013(8Z,11Z,14Z)-eicosatrienoate+0.0017(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate+0.0001eicosanoate+0.0001elaidic acid+0.0013(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate+0.0048MAM01932c+0.0001MAM02053c+0.0001dodecanoate+0.0001tetracosanoate+0.0741linoleic acid+0.0037alpha-linolenic acid+0.0001MAM02456c+0.0001(5Z,8Z,11Z)-eicosatrienoate+0.0096tetradecanoate+0.0001(15Z)-tetracosenoate+0.0001MAM02613c+0.122(9Z)-octadecenoate+0.0001MAM02648c+0.64hexadecanoic acid+0.0286(9Z)-hexadecenoate+0.0001MAM02690c+0.0001MAM02745c+0.082octadecanoate+0.0028MAM02939c+0.0001tricosanoate+0.0001MAM03051c+0.0001(17Z)-hexacosenoate
Reaction pageLeft to rightBalance undeterminablecytosol
Human-GEM MAR00685CC BY 4.0Reference data
fatty acid0.0001MAM00003c+0.0001(11Z,14Z)-eicosadienoate+0.0001MAM00010c+0.0001MAM00017c+0.0001MAM00019c+0.0001MAM00021c+0.0016MAM00094c+0.0001MAM00104c+0.0001MAM00111c+0.0001MAM00114c+0.0001MAM00115c+0.0001MAM00117c+0.0001MAM00128c+0.0001MAM00132c+0.0001MAM00135c+0.0001MAM00260c+0.0001MAM00265c+0.0001MAM00315c+0.0001MAM00341c+0.0001MAM01197c+0.0001MAM01207c+0.0001MAM01235c+0.0001MAM01238c+0.0032(7Z,10Z,13Z,16Z)-docosatetraenoate+0.0521(5Z,8Z,11Z,14Z)-eicosatetraenoate+0.0001docosanoate+0.0001hexacosanoate+0.0001MAM01582c+0.0001MAM01583c+0.0001(11Z)-eicosenoate+0.0217MAM01585c+0.0081all-cis-docosa-4,7,10,13,16,19-hexaenoic acid+0.0023(8Z,11Z,14Z)-eicosatrienoate+0.0018(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate+0.0001eicosanoate+0.0001elaidic acid+0.0003(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate+0.003MAM01932c+0.0001MAM02053c+0.0001dodecanoate+0.0001tetracosanoate+0.281linoleic acid+0.0119alpha-linolenic acid+0.0001MAM02456c+0.0001(5Z,8Z,11Z)-eicosatrienoate+0.0024tetradecanoate+0.0001(15Z)-tetracosenoate+0.0001MAM02613c+0.4226(9Z)-octadecenoate+0.0001MAM02648c+0.12hexadecanoic acid+0.0229(9Z)-hexadecenoate+0.0001MAM02690c+0.0001MAM02745c+0.0384octadecanoate+0.0025MAM02939c+0.0001tricosanoate+0.0001MAM03051c+0.0001(17Z)-hexacosenoate
Reaction pageLeft to rightBalance undeterminablecytosol
Human-GEM MAR00686CC BY 4.0Reference data
fatty acid0.0001MAM00003c+0.0001(11Z,14Z)-eicosadienoate+0.0001MAM00010c+0.0001MAM00017c+0.0001MAM00019c+0.0001MAM00021c+0.0011MAM00094c+0.0001MAM00104c+0.0001MAM00111c+0.0001MAM00114c+0.0001MAM00115c+0.0001MAM00117c+0.0001MAM00128c+0.0001MAM00132c+0.0001MAM00135c+0.0001MAM00260c+0.0001MAM00265c+0.0001MAM00315c+0.0001MAM00341c+0.0001MAM01197c+0.0001MAM01207c+0.0001MAM01235c+0.0001MAM01238c+0.0022(7Z,10Z,13Z,16Z)-docosatetraenoate+0.0264(5Z,8Z,11Z,14Z)-eicosatetraenoate+0.0001docosanoate+0.0001hexacosanoate+0.0001MAM01582c+0.0001MAM01583c+0.0001(11Z)-eicosenoate+0.0194MAM01585c+0.0221all-cis-docosa-4,7,10,13,16,19-hexaenoic acid+0.0141(8Z,11Z,14Z)-eicosatrienoate+0.0038(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate+0.0001eicosanoate+0.0001elaidic acid+0.0035(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate+0.0081MAM01932c+0.0001MAM02053c+0.0001dodecanoate+0.0001tetracosanoate+0.278linoleic acid+0.0023alpha-linolenic acid+0.0001MAM02456c+0.0001(5Z,8Z,11Z)-eicosatrienoate+0.003tetradecanoate+0.0001(15Z)-tetracosenoate+0.0001MAM02613c+0.4519(9Z)-octadecenoate+0.0001MAM02648c+0.0849hexadecanoic acid+0.014(9Z)-hexadecenoate+0.0001MAM02690c+0.0001MAM02745c+0.0584octadecanoate+0.0026MAM02939c+0.0001tricosanoate+0.0001MAM03051c+0.0001(17Z)-hexacosenoate
Reaction pageLeft to rightBalance undeterminablecytosol
Human-GEM MAR00687CC BY 4.0Reference data
fatty acid0.0005MAM00003c+0.0005(11Z,14Z)-eicosadienoate+0.0005MAM00010c+0.0005MAM00017c+0.0005MAM00019c+0.0005MAM00021c+0.0039MAM00094c+0.0005MAM00104c+0.0005MAM00111c+0.0005MAM00114c+0.0005MAM00115c+0.0005MAM00117c+0.0005MAM00128c+0.0005MAM00132c+0.0005MAM00135c+0.0005MAM00260c+0.0005MAM00265c+0.0005MAM00315c+0.0005MAM00341c+0.0005MAM01197c+0.0005MAM01207c+0.0005MAM01235c+0.0005MAM01238c+0.0011(7Z,10Z,13Z,16Z)-docosatetraenoate+0.0709(5Z,8Z,11Z,14Z)-eicosatetraenoate+0.0005docosanoate+0.0005hexacosanoate+0.0005MAM01582c+0.0005MAM01583c+0.0005(11Z)-eicosenoate+0.0271MAM01585c+0.0252all-cis-docosa-4,7,10,13,16,19-hexaenoic acid+0.0228(8Z,11Z,14Z)-eicosatrienoate+0.0056(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate+0.0005eicosanoate+0.0005elaidic acid+0.0109(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate+0.0036MAM01932c+0.0005MAM02053c+0.0005dodecanoate+0.0005tetracosanoate+0.2479linoleic acid+0.0047alpha-linolenic acid+0.0005MAM02456c+0.0005(5Z,8Z,11Z)-eicosatrienoate+0.0054tetradecanoate+0.0005(15Z)-tetracosenoate+0.0005MAM02613c+0.1143(9Z)-octadecenoate+0.0178MAM02648c+0.2781hexadecanoic acid+0.0105(9Z)-hexadecenoate+0.0005MAM02690c+0.0005MAM02745c+0.1271octadecanoate+0.0026MAM02939c+0.0005tricosanoate+0.0005MAM03051c+0.0005(17Z)-hexacosenoate
Reaction pageReversibleBalance undeterminablecytosol
Human-GEM MAR00688CC BY 4.0Reference data

Show the remaining 18

Where it reaches

10 systems, 25 regions, 129 tissues, 171 transporter routes — routes, not measurements: transporters known to carry hexacosanoate are expressed there, and no source reports it arriving.

Loading the model…

Nervous

Endocrine

Respiratory

Cardiovascular

Digestive

Urinary

Reproductive

Blood and immune

Musculoskeletal

Skin and adipose

Other names

8 names

Resolves to: hexacosanoate

Also called: cerateceratinatecerinatecerotatecerylateCH3-[CH2]24-COO(-)CH3‒[CH2]24‒COO−n-hexacosanoate