maltitol

acid production after sucrose rinsing following prolonged sweetener use

no effect, n = 13

When the effect of prolonged use of sweeteners on acid production after sucrose rinsing was compared, there were no statistically significant differences between the sweeteners

PMID:10666962 · one of two readings recorded this

dental plaque pH (minimum pH and cH area) after 14 days of maltitol lozenges compared with sucrose, sorbitol and xylitol lozenges

no effect, no statistically significant differences between sweeteners in acid production after sucrose rinsing

Not recorded as a finding: the comparison was against another active treatment

When the effect of prolonged use of sweeteners on acid production after sucrose rinsing was compared, there were no statistically significant differences between the sweeteners.

PMID:10666962 · one of two readings recorded this

dental plaque pH, minimum pH and cH area, after 14 days of sweetener lozenges

no effect, no significant difference between xylitol and maltitol; no differences between sweeteners after sucrose rinse, n = 13

Not recorded as a finding: the comparison was against another active treatment

Dental plaque does not adapt to metabolise xylitol or maltitol following prolonged exposure over 14 days.

PMID:10666962 · one of two readings recorded this

plaque adaptation to sweetener metabolism (xylitol vs maltitol)

no effect, n = 13

there was a statistically significant difference (p = 0.033) between xylitol and sorbitol, and between xylitol and sucrose but not between xylitol and maltitol

PMID:10666962 · one of two readings recorded this

plaque adaptation to sweetener metabolism (xylitol vs sorbitol and sucrose)

unclear, p = 0.033, n = 13

there was a statistically significant difference (p = 0.033) between xylitol and sorbitol, and between xylitol and sucrose but not between xylitol and maltitol

PMID:10666962 · one of two readings recorded this

45Ca remaining in the gastrointestinal tract

decreases

the amount of 45Ca remaining in the gastrointestinal tract at 6h after its administration was smaller in the rats fed maltitol diet than in the rats fed glucose diet

PMID:1453238 · one of two readings recorded this

calcium retention

increases

Feeding maltitol diets as well as sorbitol diet led to a significantly elevated intestinal calcium absorption and calcium retention

PMID:1453238 · one of two readings recorded this

calcium retention

increases

Feeding maltitol diets as well as sorbitol diet led to a significantly elevated intestinal calcium absorption and calcium retention

PMID:1453238 · one of two readings recorded this

intestinal calcium absorption and calcium retention by 5-day calcium balance study in rats; gastrointestinal calcium and 45Ca remaining at 6 h

increases

Not recorded as a finding: this platform holds no node for the endpoint

Feeding maltitol diets as well as sorbitol diet led to a significantly elevated intestinal calcium absorption and calcium retention.

PMID:1453238 · one of two readings recorded this

intestinal calcium absorption and calcium retention by 5-day calcium balance study in rats

increases

Not recorded as a finding: this platform holds no node for the endpoint

Feeding maltitol diets as well as sorbitol diet led to a significantly elevated intestinal calcium absorption and calcium retention.

PMID:1453238 · one of two readings recorded this

intestinal calcium absorption

no effect

Lactose diet did not produce an increased intestinal calcium absorption in the condition used in the present study

PMID:1453238 · one of two readings recorded this

intestinal calcium absorption

increases

Feeding maltitol diets as well as sorbitol diet led to a significantly elevated intestinal calcium absorption and calcium retention

PMID:1453238 · one of two readings recorded this

intestinal calcium absorption

increases

Feeding maltitol diets as well as sorbitol diet led to a significantly elevated intestinal calcium absorption and calcium retention

PMID:1453238 · one of two readings recorded this

total calcium remaining in the gastrointestinal tract

decreases

The total calcium remaining in the gastrointestinal tract at 6h after feeding was significantly decreased in the rats given maltitol diet as compared to the rats given glucose diet

PMID:1453238 · one of two readings recorded this

chromosome aberrations

increases

Maltitol induced CA, although not statistically significantly

PMID:16777705 · one of two readings recorded this

medium pH and osmolality

no effect

Maltitol did not alter the pH and osmolality of the medium

PMID:16777705 · one of two readings recorded this

micronucleus frequency

increases

Maltitol induced the frequency of MN at 24 and 48 h in a non-dose-dependent manner

PMID:16777705 · one of two readings recorded this

micronucleus frequency

increases

Maltitol induced the frequency of MN at 24 and 48 h in a non-dose-dependent manner

PMID:16777705 · one of two readings recorded this

replication index and mitotic index

no effect

In addition, maltitol did not decrease the replication index (RI) and the mitotic index (MI) at all concentrations and treatment periods

PMID:16777705 · one of two readings recorded this

sister chromatid exchange, chromosome aberration, micronucleus frequency, replication index and mitotic index in human peripheral lymphocytes in vitro

increases, induced micronucleus frequency at 24 and 48 h, non-dose-dependent

Not recorded as a finding: this platform holds no node for the endpoint

Maltitol induced the frequency of MN at 24 and 48 h in a non-dose-dependent manner.

PMID:16777705 · both readings recorded this

sister chromatid exchange

no effect

Maltitol did not induce SCE at all concentrations (1.25, 2.5, and 5 mg/mL) and treatment periods (24 and 48 h)

PMID:16777705 · one of two readings recorded this

absorption coefficient of glucose (percentage of infused glucose appearing in the portal blood)

no effect

The absorption coefficient of glucose (percentage of infused glucose appearing in the portal blood) was the same 8 h after infusion of maltitol (78.1%) and maltose (78.8%)

PMID:2019883 · one of two readings recorded this

absorption coefficient of sorbitol

Sorbitol was poorly absorbed, with an absorption coefficient of 7.2% after 8 h

PMID:2019883 · one of two readings recorded this

appearance of aminonitrogen in the portal vein

increases

Aminonitrogen from milk oligopeptides appeared more rapidly in the portal vein during the first 4 h after infusion of maltitol than after that of maltose

PMID:2019883 · one of two readings recorded this

glucose absorption inhibition by luminal sorbitol

no effect

Its presence in the gut lumen did not inhibit the absorption of glucose

PMID:2019883 · one of two readings recorded this

portal-blood appearance of glucose, sorbitol and aminonitrogen after duodenal infusion of maltitol-rich versus maltose-rich syrup in pigs

no effect, 78.1% after maltitol vs 78.8% after maltose

Not recorded as a finding: this platform holds no node for the endpoint

The absorption coefficient of glucose (percentage of infused glucose appearing in the portal blood) was the same 8 h after infusion of maltitol (78.1%) and maltose (78.8%).

PMID:2019883 · one of two readings recorded this

portal-vein appearance of glucose (absorption coefficient), sorbitol and aminonitrogen after duodenal infusion in pigs

no effect, glucose absorption coefficient 78.1% after maltitol vs 78.8% after maltose, n = 4

Not recorded as a finding: the comparison was against another active treatment

The absorption coefficient of glucose (percentage of infused glucose appearing in the portal blood) was the same 8 h after infusion of maltitol (78.1%) and maltose (78.8%).

PMID:2019883 · one of two readings recorded this

14CO2 recovery after [U-14C]maltitol, radioactivity in urine, faeces and intestinal contents, caecal and small-intestinal content of maltitol and sorbitol in conventional and germ-free mice and rats

decreases, 14CO2 recovery 59% in germ-free mice vs 72-74% in conventional animals

Not recorded as a finding: this platform holds no node for the endpoint

The percentage recovery of 14CO2 was significantly lower for the GF mice (59%) compared with C animals (72-74%).

PMID:2107869 · one of two readings recorded this

alpha-glucosidase (maltase) activity of the small intestine

increases

The alpha-glucosidase (maltase) (EC3.2.1.20) activity of the small intestine was appreciably higher (1.5-1.7 times) in the GF mice than in the C mice

PMID:2107869 · one of two readings recorded this

ingested dose remaining in caecum and small intestine

The caecum and small intestine of GF mice, 3 h after administration of equimolar quantities of maltitol (140 mg/kg body-weight) or sorbitol (70 mg/kg body-weight), contained 39 and 51% of the ingested dose respectively

PMID:2107869 · one of two readings recorded this

percentage recovery of 14CO2

decreases

The percentage recovery of 14CO2 was significantly lower for the GF mice (59%) compared with C animals (72-74%)

PMID:2107869 · one of two readings recorded this

radioactivity in urine, faeces and intestinal contents

Urine, faeces and intestinal contents after 48 h totalled 19% of the administered radioactivity in the C rats and mice and 39% in the GF mice

PMID:2107869 · one of two readings recorded this

radioactivity in urine, faeces and intestinal contents

increases

Urine, faeces and intestinal contents after 48 h totalled 19% of the administered radioactivity in the C rats and mice and 39% in the GF mice

PMID:2107869 · one of two readings recorded this

chromosome aberrations and mitotic index in rat bone marrow cells; teratogenicity and foetal weight in rats (intraperitoneal maltitol)

no effect, did not induce CA and did not decrease mitotic index at any concentration or period

Not recorded as a finding: this platform holds no node for the endpoint

Maltitol did not induce the CA and did not decrease the mitotic index in bone marrow cells of rats at all concentrations and treatment periods.

PMID:22585934 · one of two readings recorded this

chromosome aberrations and mitotic index in rat bone marrow cells; teratogenicity, embryotoxicity and foetal weight in rats (intraperitoneal maltitol)

no effect, did not induce chromosome aberrations or decrease mitotic index at any concentration or period

Not recorded as a finding: this platform holds no node for the endpoint

Maltitol did not induce the CA and did not decrease the mitotic index in bone marrow cells of rats at all concentrations and treatment periods.

PMID:22585934 · one of two readings recorded this

chromosome aberrations in bone marrow cells

no effect

Maltitol did not induce the CA and did not decrease the mitotic index in bone marrow cells of rats at all concentrations and treatment periods

PMID:22585934 · one of two readings recorded this

foetal growth retardation

increases

In addition, maltitol was not teratogenic; however, it decreased the foetuses weight and at the highest dose (4 g/kg bw) caused growth retardation

PMID:22585934 · one of two readings recorded this

foetus weight

decreases

In addition, maltitol was not teratogenic; however, it decreased the foetuses weight and at the highest dose (4 g/kg bw) caused growth retardation

PMID:22585934 · one of two readings recorded this

mitotic index in bone marrow cells

no effect

Maltitol did not induce the CA and did not decrease the mitotic index in bone marrow cells of rats at all concentrations and treatment periods

PMID:22585934 · one of two readings recorded this

teratogenicity

no effect

In addition, maltitol was not teratogenic; however, it decreased the foetuses weight and at the highest dose (4 g/kg bw) caused growth retardation

PMID:22585934 · one of two readings recorded this

hepatic fatty degeneration

decreases

Intake of 5.0% maltitol for 8 weeks significantly suppressed weight gain, hepatic fatty degeneration, hyperglycemia, and hypercholesterolemia

PMID:26061453 · one of two readings recorded this

hepatic FXR expression

increases

With maltitol intake, sterol regulatory element-binding protein 1c (SREBP1c) mRNA expression was significantly decreased, and farnesoid X receptor (FXR), peroxisome proliferator-activated receptor α (PPARα), and hydroxymethylglutaryl-Co reductase expressions were significantly higher in the liver

PMID:26061453 · one of two readings recorded this

hepatic hydroxymethylglutaryl-CoA reductase expression

increases

With maltitol intake, sterol regulatory element-binding protein 1c (SREBP1c) mRNA expression was significantly decreased, and farnesoid X receptor (FXR), peroxisome proliferator-activated receptor α (PPARα), and hydroxymethylglutaryl-Co reductase expressions were significantly higher in the liver

PMID:26061453 · one of two readings recorded this

hepatic PPARα expression

increases

With maltitol intake, sterol regulatory element-binding protein 1c (SREBP1c) mRNA expression was significantly decreased, and farnesoid X receptor (FXR), peroxisome proliferator-activated receptor α (PPARα), and hydroxymethylglutaryl-Co reductase expressions were significantly higher in the liver

PMID:26061453 · one of two readings recorded this

hepatic SREBP1c mRNA expression

decreases

With maltitol intake, sterol regulatory element-binding protein 1c (SREBP1c) mRNA expression was significantly decreased, and farnesoid X receptor (FXR), peroxisome proliferator-activated receptor α (PPARα), and hydroxymethylglutaryl-Co reductase expressions were significantly higher in the liver

PMID:26061453 · one of two readings recorded this

hypercholesterolemia

decreases

Intake of 5.0% maltitol for 8 weeks significantly suppressed weight gain, hepatic fatty degeneration, hyperglycemia, and hypercholesterolemia

PMID:26061453 · one of two readings recorded this

hyperglycemia and hypercholesterolemia in high-fat-fed mice, measurement not described in the abstract

decreases

Not recorded as a finding: Instrument and sample not stated in the abstract; fasting blood glucose and total cholesterol nodes are bound to a stated assay or fast.

Intake of 5.0% maltitol for 8 weeks significantly suppressed weight gain, hepatic fatty degeneration, hyperglycemia, and hypercholesterolemia.

PMID:26061453 · one of two readings recorded this

hyperglycemia (glucose measure not specified), hypercholesterolemia (cholesterol fraction not specified)

decreases

Not recorded as a finding: Abstract names no assay, fasting state or cholesterol fraction, so no fasting-blood-glucose or total-cholesterol node requirement is met.

Intake of 5.0% maltitol for 8 weeks significantly suppressed weight gain, hepatic fatty degeneration, hyperglycemia, and hypercholesterolemia.

PMID:26061453 · one of two readings recorded this

hyperglycemia

decreases

Intake of 5.0% maltitol for 8 weeks significantly suppressed weight gain, hepatic fatty degeneration, hyperglycemia, and hypercholesterolemia

PMID:26061453 · one of two readings recorded this

weight gain, hepatic fatty degeneration, hyperglycemia and hypercholesterolemia in high-fat-diet C57BL/6 mice

decreases, significant suppression of weight gain, hepatic fatty degeneration, hyperglycemia and hypercholesterolemia with 5.0% maltitol for 8 weeks

Not recorded as a finding: a node exists but the paper states a different instrument or population

Intake of 5.0% maltitol for 8 weeks significantly suppressed weight gain, hepatic fatty degeneration, hyperglycemia, and hypercholesterolemia.

PMID:26061453 · one of two readings recorded this

weight gain, hepatic fatty degeneration, hyperglycemia and hypercholesterolemia in high-fat-diet mice; liver SREBP1c, FXR, PPARalpha mRNA expression

decreases, 5.0% maltitol for 8 weeks significantly suppressed weight gain, hepatic fatty degeneration, hyperglycemia and hypercholesterolemia

Not recorded as a finding: this platform holds no node for the endpoint

Intake of 5.0% maltitol for 8 weeks significantly suppressed weight gain, hepatic fatty degeneration, hyperglycemia, and hypercholesterolemia.

PMID:26061453 · one of two readings recorded this

weight gain

decreases

Intake of 5.0% maltitol for 8 weeks significantly suppressed weight gain, hepatic fatty degeneration, hyperglycemia, and hypercholesterolemia

PMID:26061453 · one of two readings recorded this

glucose absorption in isolated jejunum

decreases

Maltitol inhibited glucose absorption in isolated rat jejunum and increased glucose uptake in isolated rat psoas muscle in the presence of insulin but not in the absence of insulin

PMID:27687609 · one of two readings recorded this

glucose absorption in isolated rat jejunum and insulin-mediated glucose uptake in isolated rat psoas muscle (ex vivo); small intestinal glucose absorption, blood glucose, gastric emptying and digesta transit in rats (in vivo)

no effect, no significant alteration of small intestinal glucose absorption or blood glucose in normal or type 2 diabetic rats

Not recorded as a finding: this platform holds no node for the endpoint

In contrast, maltitol did not significantly (p > 0.05) alter small intestinal glucose absorption or blood glucose levels as well as gastric emptying and digesta transit in normal or type 2 diabetic rats.

PMID:27687609 · one of two readings recorded this

glucose absorption in isolated rat jejunum, glucose uptake in isolated rat psoas muscle, gastric emptying and digesta transit in rats

decreases, inhibited glucose absorption in isolated jejunum; no significant change in vivo

Not recorded as a finding: this platform holds no node for the endpoint

Maltitol inhibited glucose absorption in isolated rat jejunum and increased glucose uptake in isolated rat psoas muscle in the presence of insulin but not in the absence of insulin.

PMID:27687609 · one of two readings recorded this

glucose uptake in isolated psoas muscle with insulin

increases

Maltitol inhibited glucose absorption in isolated rat jejunum and increased glucose uptake in isolated rat psoas muscle in the presence of insulin but not in the absence of insulin

PMID:27687609 · one of two readings recorded this

glucose uptake in isolated psoas muscle without insulin

no effect

Maltitol inhibited glucose absorption in isolated rat jejunum and increased glucose uptake in isolated rat psoas muscle in the presence of insulin but not in the absence of insulin

PMID:27687609 · one of two readings recorded this

small intestinal glucose absorption, blood glucose, gastric emptying and digesta transit in vivo

no effect, p = 0.05

maltitol did not significantly (p > 0.05) alter small intestinal glucose absorption or blood glucose levels as well as gastric emptying and digesta transit in normal or type 2 diabetic rats

PMID:27687609 · one of two readings recorded this

hemolysis

p(ML) and m-(ML)/DETA particles are blood compatible with about 5% hemolysis

PMID:29752090 · one of two readings recorded this

L929 fibroblast cell viability

at 200 μg/mL dosage of p(ML), m-p(ML)/TA and m-p(ML)/DETA particles, the cell viabilities were determined as 83.33, 64.03 and 73.89% on for L929 fibroblast cells

PMID:29752090 · one of two readings recorded this

L929 fibroblast cell viability

at 200 μg/mL dosage of p(ML), m-p(ML)/TA and m-p(ML)/DETA particles, the cell viabilities were determined as 83.33, 64.03 and 73.89% on for L929 fibroblast cells

PMID:29752090 · one of two readings recorded this

L929 fibroblast cell viability

p(ML) based particle are biocompatible up to 100 μg/mL with 85% cell viability

PMID:29752090 · one of two readings recorded this

L929 fibroblast cell viability

at 200 μg/mL dosage of p(ML), m-p(ML)/TA and m-p(ML)/DETA particles, the cell viabilities were determined as 83.33, 64.03 and 73.89% on for L929 fibroblast cells

PMID:29752090 · one of two readings recorded this

synthesis yield of poly(maltitol) particles

with a high yield, 89 ± 6%

PMID:29752090 · one of two readings recorded this

bread chewiness

decreases, p = 0.05

Breads with 6% of maltitol exhibited lower hardness and chewiness, with a significant decrease of 42% and 31%, respectively (p < 0.05)

PMID:30722851 · one of two readings recorded this

bread hardness

decreases, p = 0.05

Breads with 6% of maltitol exhibited lower hardness and chewiness, with a significant decrease of 42% and 31%, respectively (p < 0.05)

PMID:30722851 · one of two readings recorded this

dough fermentation rate

decreases

The presence of maltitol could slow down the fermentation rate of dough

PMID:30722851 · one of two readings recorded this

gelatinization temperature

increases, p = 0.05

The use of maltitol could remarkably enhance the gelatinization temperature (p < 0.05) that was confirmed by DSC tool

PMID:30722851 · one of two readings recorded this

mobility of immobilized water

increases

Through the approach of LF-NMR, the addition of maltitol could increase the mobility of immobilized water, further retarded bread staling

PMID:30722851 · one of two readings recorded this

retrogradation kinetics k values (chewiness and total signal amplitude)

decreases

The k values from chewiness and total signal amplitude in breads with 2% and 4% levels of maltitol were smaller than the control

PMID:30722851 · one of two readings recorded this

wheat bread hardness and chewiness (texture analysis), gelatinization temperature (DSC), water mobility (LF-NMR), staling kinetics

decreases, hardness and chewiness decreased by 42% and 31% with 6% maltitol

Not recorded as a finding: this platform holds no node for the endpoint

Breads with 6% of maltitol exhibited lower hardness and chewiness, with a significant decrease of 42% and 31%, respectively (p < 0.05).

PMID:30722851 · one of two readings recorded this

wheat bread hardness and chewiness (texture), gelatinization temperature by DSC, water mobility by LF-NMR

decreases, hardness decreased 42% and chewiness 31% with 6% maltitol

Not recorded as a finding: this platform holds no node for the endpoint

Breads with 6% of maltitol exhibited lower hardness and chewiness, with a significant decrease of 42% and 31%, respectively (p < 0.05).

PMID:30722851 · one of two readings recorded this

binding free energy (ΔGbind) to TAS1R2

the binding affinity of the maltitol/TAS1R2 complex (ΔGbind of -17.93 ± 1.49 kcal/mol) was significantly higher than that of the lactitol/TAS1R2 system (-8.53 ± 1.78 kcal/mol)

PMID:32551626 · one of two readings recorded this

binding free energy (ΔGbind) to TAS1R2

the binding affinity of the maltitol/TAS1R2 complex (ΔGbind of -17.93 ± 1.49 kcal/mol) was significantly higher than that of the lactitol/TAS1R2 system (-8.53 ± 1.78 kcal/mol)

PMID:32551626 · one of two readings recorded this

preferential binding site (TAS1R2 monomer versus TAS1R3 region)

revealed that the TAS1R2 monomer is the preferential binding site for maltitol and lactitol rather than the TAS1R3 region

PMID:32551626 · one of two readings recorded this

cumulated suprabasal glucose oxidation relative to sucrose

decreases

Maltitol resulted in a cumulated suprabasal glucose oxidation which amounted to 40% that obtained with sucrose after 180 min

PMID:3298708 · one of two readings recorded this

delta glucose oxidation

decreases

The delta glucose oxidation was significantly lower with maltitol than with sucrose during the first 90 min after the ingestion of the load

PMID:3298708 · one of two readings recorded this

delta glucose oxidation

no effect

It was slightly higher (although not significantly) with maltitol than with sucrose starting from the 210th min

PMID:3298708 · one of two readings recorded this

peak delta plasma glucose concentration

decreases, p = 0.02

The peak of the delta glucose concentration was significantly smaller after maltitol than after sucrose (21 +/- 4 vs 38 +/- 4 mg/100 ml, p less than 0.02)

PMID:3298708 · one of two readings recorded this

peak delta plasma insulin concentration

decreases, p = 0.001

as was the peak of the delta insulin concentration (9.3 +/- 2.7 microU/ml after maltitol vs 25.5 +/- 5.0 microU/ml after sucrose, p less than 0.001)

PMID:3298708 · one of two readings recorded this

peak rise in plasma glucose and insulin and glucose oxidation by continuous indirect calorimetry after a 30 g oral load of maltitol versus sucrose in eight normal subjects

decreases, peak delta glucose 21 +/- 4 vs 38 +/- 4 mg/100 ml after maltitol vs sucrose

Not recorded as a finding: the comparison was against another active treatment

The peak of the delta glucose concentration was significantly smaller after maltitol than after sucrose (21 +/- 4 vs 38 +/- 4 mg/100 ml, p less than 0.02), as was the peak of the delta insulin concentration (9.3 +/- 2.7 microU/ml after maltitol vs 25.5 +/- 5.0 microU/ml after sucrose, p less than 0.001).

PMID:3298708 · one of two readings recorded this

peak rise in plasma glucose, plasma insulin and free fatty acids, and carbohydrate and lipid oxidation by continuous indirect calorimetry over 6 h after a 30 g oral load

decreases, peak delta glucose 21 +/- 4 vs 38 +/- 4 mg/100 ml, p = 0.02, n = 8

Not recorded as a finding: the comparison was against another active treatment

The peak of the delta glucose concentration was significantly smaller after maltitol than after sucrose (21 +/- 4 vs 38 +/- 4 mg/100 ml, p less than 0.02), as was the peak of the delta insulin concentration (9.3 +/- 2.7 microU/ml after maltitol vs 25.5 +/- 5.0 microU/ml after sucrose, p less than 0.001).

PMID:3298708 · one of two readings recorded this

time of peak stimulation of glucose oxidation

The peak of the stimulation of glucose oxidation occurred 60 min after the load of sucrose and 90 min after the load of maltitol

PMID:3298708 · one of two readings recorded this

time of peak stimulation of glucose oxidation

The peak of the stimulation of glucose oxidation occurred 60 min after the load of sucrose and 90 min after the load of maltitol

PMID:3298708 · one of two readings recorded this

time of plasma glucose peak

no effect

Plasma glucose and insulin peaks occurred 30 min after ingestion of the load for both sugars

PMID:3298708 · one of two readings recorded this

time of plasma insulin peak

no effect

Plasma glucose and insulin peaks occurred 30 min after ingestion of the load for both sugars

PMID:3298708 · one of two readings recorded this

antibacterial activity against S. mutans, disc diffusion inhibition zone

increases, inhibition zone 14.0 ± 3.0 mm at 40 mg/disc

By disc diffusion (Table 3), standard and synthesized maltitols (40 mg/disc) exhibited moderate antibacterial activity against S. mutans, with inhibition zones of 14.0 ± 3.0 mm.

PMID:35204667 · one of two readings recorded this

Antibacterial zone of inhibition against S. mutans by disc diffusion

decreases, inhibition zone 14.0 ± 3.0 mm at 40 mg/disc for standard and synthesized maltitol

By disc diffusion (Table 3), standard and synthesized maltitols (40 mg/disc) exhibited moderate antibacterial activity against S. mutans, with inhibition zones of 14.0 ± 3.0 mm.

PMID:35204667 · one of two readings recorded this

Growth inhibition of Streptococcus mutans DMST 18777 (spot assay, colony formation at serial dilutions)

decreases

In the BHI agar medium containing 2% (w/ v) of standard and synthetic maltitols, S. mutans colonies did not form when the plates were seeded with bacterial inoculate at a 108 dilution.

PMID:35204667 · one of two readings recorded this

Growth-inhibitory and antibacterial activity of maltitol against Streptococcus mutans DMST 18777 (spot assay, disc diffusion, MIC, MBC)

decreases

Not recorded as a finding: this platform holds no node for the endpoint

The lowest MIC and MBC values for synthesized maltitol were 20 and 40 mg/mL against S. mutans, respectively (Table 4).

PMID:35204667 · one of two readings recorded this

Minimum inhibitory and bactericidal concentration against S. mutans

decreases, MIC 20 mg/mL, MBC 40 mg/mL for synthesized maltitol

The lowest MIC and MBC values for synthesized maltitol were 20 and 40 mg/mL against S. mutans, respectively (Table 4).

PMID:35204667 · one of two readings recorded this

minimum inhibitory and bactericidal concentration against S. mutans

MIC 20 mg/mL, MBC 40 mg/mL

The lowest MIC and MBC values for synthesized maltitol were 20 and 40 mg/mL against S. mutans, respectively (Table 4).

PMID:35204667 · one of two readings recorded this

Streptococcus mutans colony growth, spot assay

decreases

The results of the spot assay indicated that the numbers of S. mutans colonies were lower in the presence of standard and synthetic maltitols compared to no additional supplement, glucose and sorbitol.

PMID:35204667 · one of two readings recorded this

Streptococcus mutans growth inhibition by maltitol, spot assay, disc diffusion, MIC and MBC

decreases

Not recorded as a finding: this platform holds no node for the endpoint

By disc diffusion (Table 3), standard and synthesized maltitols (40 mg/disc) exhibited moderate antibacterial activity against S. mutans, with inhibition zones of 14.0 ± 3.0 mm.

PMID:35204667 · one of two readings recorded this

capacity to hydrolyse sugar alcohols, normal versus abnormal biopsies

no effect

All biopsies, normal as well as abnormal, showed essentially the same capacity to hydrolyse the sugar alcohols

PMID:3676242 · one of two readings recorded this

glucose release from maltose hydrolysis

decreases

Glucose release was reduced by approximately 25% when maltitol or Palatinit were present at concentrations equal to those of maltose

PMID:3676242 · one of two readings recorded this

glucose release from maltose hydrolysis

decreases

Glucose release was reduced by approximately 25% when maltitol or Palatinit were present at concentrations equal to those of maltose

PMID:3676242 · one of two readings recorded this

hydrolysis activity towards lactitol

Activities towards lactitol (0.34 IE/g protein (where IE = mumol disaccharide hydrolysed/min at 37 degrees)) and Palatinit (2.50 IE/g protein) were only 1.3% of those towards lactose and isomaltose

PMID:3676242 · one of two readings recorded this

hydrolysis activity towards maltitol

The activity towards maltitol was much higher (19.1 IE/g protein), approximately 10% of that towards maltose and about as high as the activity towards trehalose

PMID:3676242 · one of two readings recorded this

hydrolysis activity towards Palatinit

Activities towards lactitol (0.34 IE/g protein (where IE = mumol disaccharide hydrolysed/min at 37 degrees)) and Palatinit (2.50 IE/g protein) were only 1.3% of those towards lactose and isomaltose

PMID:3676242 · one of two readings recorded this

hydrolysis of maltitol, lactitol and Palatinit by homogenates of human intestinal biopsies (IE/g protein), compared with maltose, lactose and isomaltose

maltitol hydrolysis 19.1 IE/g protein, approximately 10% of that towards maltose

Not recorded as a finding: this platform holds no node for the endpoint

The activity towards maltitol was much higher (19.1 IE/g protein), approximately 10% of that towards maltose and about as high as the activity towards trehalose.

PMID:3676242 · one of two readings recorded this

hydrolysis of sucrose

decreases

Palatinit decreased the hydrolysis of sucrose by 12%

PMID:3676242 · one of two readings recorded this

inhibition of disaccharide hydrolysis

no effect

Lactitol had no inhibitory effect on the hydrolysis of disaccharides

PMID:3676242 · one of two readings recorded this

CALB loading capacity in nanoreactors

The CALB loading capacity in nanoreactors achieved 30%

PMID:37094396 · one of two readings recorded this

catalytic efficiency retained after repetitive enzymatic reactions

decreases

keep catalytic efficiency of 62.6% after eight repetitive enzymatic reactions

PMID:37094396 · one of two readings recorded this

CAT and SOD activities

increases

with upgrading CAT and SOD activities while suppressing PPO and POD activity

PMID:39823900 · one of two readings recorded this

color, water content and antioxidant activity of spinach and oilseed rape

increases

the combination of maltitol with LA/TA preserved the color, water content, and antioxidant activity of spinach and oilseed rape

PMID:39823900 · one of two readings recorded this

PPO and POD activity

decreases

with upgrading CAT and SOD activities while suppressing PPO and POD activity

PMID:39823900 · one of two readings recorded this

yellowing and water loss of leafy greens

decreases

LA/TA-maltitol effectively delayed yellowing and water loss while inhibiting rot-causing bacteria

PMID:39823900 · one of two readings recorded this

Genotoxicity by in vitro micronucleus test in human peripheral blood lymphocytes

no effect

Similarly, the in-vitro micronucleus test, performed at concentrations demonstrating lower cytotoxicity (<55 ± 5%), revealed no statistically significant induction of micronuclei.

PMID:41933646 · one of two readings recorded this

genotoxicity, in-vitro micronucleus induction in human peripheral blood lymphocytes

no effect

Similarly, the in-vitro micronucleus test, performed at concentrations demonstrating lower cytotoxicity (<55 ± 5%), revealed no statistically significant induction of micronuclei.

PMID:41933646 · one of two readings recorded this

mutagenicity, bacterial reverse mutation assay (Ames test)

no effect

The bacterial reverse mutation assays showed no significant increase in revertant colonies across all tested strains and conditions.

PMID:41933646 · one of two readings recorded this

Mutagenicity (bacterial reverse mutation assay) and genotoxicity (in vitro micronucleus test in human peripheral blood lymphocytes) of maltitol

no effect

Not recorded as a finding: this platform holds no node for the endpoint

Maltitol was confirmed to be non-mutagenic and non-genotoxic under the experimental conditions tested.

PMID:41933646 · one of two readings recorded this

Mutagenicity by bacterial reverse mutation (Ames) assay

no effect

The bacterial reverse mutation assays showed no significant increase in revertant colonies across all tested strains and conditions.

PMID:41933646 · one of two readings recorded this

mutagenicity of maltitol by bacterial reverse mutation assay and genotoxicity by in-vitro micronucleus test in human peripheral blood lymphocytes

no effect

Not recorded as a finding: this platform holds no node for the endpoint

The bacterial reverse mutation assays showed no significant increase in revertant colonies across all tested strains and conditions.

PMID:41933646 · one of two readings recorded this

calcium signaling proteins MID1 and CMD1 expression

increases

The composite modifier enhanced the expression of key calcium signaling proteins (MID1, CMD1) while maintaining calcineurin (CaN) activity at optimal levels

PMID:42215203 · one of two readings recorded this

fermentation capacity and cellular integrity after FT cycles

increases

Consequently, yeast treated with CA + M maintained superior fermentation capacity and cellular integrity after FT cycles

PMID:42215203 · one of two readings recorded this

FT-induced overexpression of calcium signaling genes (MID1, CCH1, CNA1, CMD1, PMC1, PMR1)

decreases

Transcriptomic analysis revealed that the composite modifier effectively downregulated FT-induced overexpression of calcium signaling genes (MID1, CCH1, CNA1, CMD1, PMC1, PMR1)

PMID:42215203 · one of two readings recorded this

yeast cell integrity and metabolic homeostasis after freeze-thaw

increases

The composite modifier (CA + M) exhibited superior efficacy compared to individual additives in preserving yeast cell integrity and metabolic homeostasis

PMID:42215203 · one of two readings recorded this

C-C/C-H proportion

decreases

as supported by the marked decrease in C-C/C-H proportion from 45.30% to 26.22%

PMID:42235775 · one of two readings recorded this

fixed-carbon yield

increases

the fixed‑carbon yield rising from 22.54% in Control group to approximately 25.70% after OD

PMID:42235775 · one of two readings recorded this

lignocellulose decomposition temperature

increases

the decomposition temperature increasing by 16-20 °C

PMID:42235775 · one of two readings recorded this

Young's modulus

producing the highest Young's modulus (3.1 GPa)

PMID:42235775 · one of two readings recorded this

Young's modulus

maintained high stiffness (2.7 GPa)

PMID:42235775 · one of two readings recorded this

Young's modulus

the low Young's modulus (811.8 MPa) in Suc group

PMID:42235775 · one of two readings recorded this

compatibility

no effect, n = 4

A daily application of 35 g maltitol to 4 human beings does not influence the parameters of well-being, compatibility and fecal state

PMID:6651223 · one of two readings recorded this

enzymatic hydrolysis of maltitol by small intestinal mucosa of man, rat and rabbit; fraction digested on in vivo perfusion in gnotobiotic rats; well-being, compatibility and fecal state in 4 people given 35 g maltitol daily

19% digested on perfusion in gnotobiotic rats

Not recorded as a finding: this platform holds no node for the endpoint

On in vivo perfusion of maltitol (15.3 mumol/min) through the small intestine, 19% of the sugar alcohol is digested by gnotobiotic rats.

PMID:6651223 · one of two readings recorded this

fecal state

no effect, n = 4

A daily application of 35 g maltitol to 4 human beings does not influence the parameters of well-being, compatibility and fecal state

PMID:6651223 · one of two readings recorded this

fraction of perfused maltitol digested in small intestine

On in vivo perfusion of maltitol (15.3 mumol/min) through the small intestine, 19% of the sugar alcohol is digested by gnotobiotic rats

PMID:6651223 · one of two readings recorded this

ingested maltitol remaining in ileum

120 min after stomach intubation of gnotobiotic rats, only 31% of the ingested maltitol is found in the ileum

PMID:6651223 · one of two readings recorded this

intestinal hydrolysis of maltitol in man, rat and rabbit; well-being, compatibility and fecal state in 4 humans given 35 g maltitol daily

no effect, n = 4

Not recorded as a finding: this platform holds no node for the endpoint

A daily application of 35 g maltitol to 4 human beings does not influence the parameters of well-being, compatibility and fecal state.

PMID:6651223 · one of two readings recorded this

well-being

no effect, n = 4

A daily application of 35 g maltitol to 4 human beings does not influence the parameters of well-being, compatibility and fecal state

PMID:6651223 · one of two readings recorded this

clearance of intravenous maltitol from circulation

decreases

A dose of 250 mg was cleared almost completely from the circulation within 1 h

PMID:7171535 · one of two readings recorded this

faecal and urinary excretion of maltitol and sorbitol in conventional and germ-free rats after oral or intravenous maltitol; clearance of intravenous maltitol from circulation

Not recorded as a finding: this platform holds no node for the endpoint

Very little of either substance appeared in the faeces but appreciable amounts of sorbitol found in the urine indicated that the maltitol had been hydrolysed.

PMID:7171535 · one of two readings recorded this

faecal excretion of maltitol and sorbitol

Urine and faeces were collected during the following 24 h and their contents of maltitol and sorbitol were measured

PMID:7171535 · one of two readings recorded this

faecal recovery of maltitol and sorbitol, CV versus germ-free

decreases

Significantly less of both substances was recovered in the faeces of CV rats, but urinary excretion was similar in both environments

PMID:7171535 · one of two readings recorded this

sorbitol in excreta after intravenous maltitol

Maltitol injected intravenously gave rise to only traces of sorbitol in the excreta

PMID:7171535 · one of two readings recorded this

urinary excretion of maltitol and sorbitol, CV versus germ-free

no effect

Significantly less of both substances was recovered in the faeces of CV rats, but urinary excretion was similar in both environments

PMID:7171535 · one of two readings recorded this

urinary sorbitol after oral maltitol

increases

Very little of either substance appeared in the faeces but appreciable amounts of sorbitol found in the urine indicated that the maltitol had been hydrolysed

PMID:7171535 · one of two readings recorded this

breaking force of femoral bone, femoral calcium content, tibial metaphysis mineral bone density, intestinal calcium absorption and retention (balance study) in ovariectomized rats; comparator 10% maltose diet

increases, 5-7% higher breaking force

Not recorded as a finding: this platform holds no node for the endpoint

The breaking force of femoral bones was significantly elevated (by 5-7%) in animals fed the maltitol diet compared with that in rats fed the maltose diet.

PMID:7472668 · one of two readings recorded this

breaking force of femoral bone, femoral calcium content, tibial metaphysis mineral bone density, intestinal calcium absorption in ovariectomized rats

increases, 5-7% higher femoral breaking force

Not recorded as a finding: the comparison was against another active treatment

The breaking force of femoral bones was significantly elevated (by 5-7%) in animals fed the maltitol diet compared with that in rats fed the maltose diet.

PMID:7472668 · one of two readings recorded this

breaking force of femoral bone

increases

The breaking force of femoral bones was significantly elevated (by 5-7%) in animals fed the maltitol diet compared with that in rats fed the maltose diet

PMID:7472668 · one of two readings recorded this

calcium content of femoral bone

increases

The calcium content in the femoral bones as well as the mineral bone density of the tibial metaphysis was also elevated in rats fed the maltitol diet

PMID:7472668 · one of two readings recorded this

intestinal calcium absorption and retention

increases

Balance studies performed during the final 5-d (Experiment 1) or 2-d (Experiment 2) period of the experiments showed that maltitol increased intestinal calcium absorption and retention

PMID:7472668 · one of two readings recorded this

mineral bone density of tibial metaphysis

increases

The calcium content in the femoral bones as well as the mineral bone density of the tibial metaphysis was also elevated in rats fed the maltitol diet

PMID:7472668 · one of two readings recorded this

acetate and propionate concentration

no effect

Intake of the 1 g/100 g maltitol diet doubled (P < 0.05) the concentration of butyrate but did not affect acetate or propionate in the cecal contents

PMID:9482760 · one of two readings recorded this

butyrate concentration

increases, p = 0.05

Intake of the 1 g/100 g maltitol diet doubled (P < 0.05) the concentration of butyrate

PMID:9482760 · one of two readings recorded this

incidence of dimethylhydrazine-induced tumors in rat cecum and proximal colon; cecal butyrate concentration

decreases

Not recorded as a finding: this platform holds no node for the endpoint

Maltitol supplementation at 1 g/100 g of the diet significantly reduced tumor incidence in the cecum and the 5% supplement reduced tumor incidence in both the cecum and proximal colon in dimethylhydrazine-treated rats.

PMID:9482760 · one of two readings recorded this

incidence of dimethylhydrazine-induced tumors in rat cecum and proximal colon; cecal short chain fatty acid concentrations

decreases

Not recorded as a finding: this platform holds no node for the endpoint

Maltitol supplementation at 1 g/100 g of the diet significantly reduced tumor incidence in the cecum and the 5% supplement reduced tumor incidence in both the cecum and proximal colon in dimethylhydrazine-treated rats.

PMID:9482760 · one of two readings recorded this

tumor incidence

decreases

Maltitol supplementation at 1 g/100 g of the diet significantly reduced tumor incidence in the cecum

PMID:9482760 · one of two readings recorded this

tumor incidence

decreases

the 5% supplement reduced tumor incidence in both the cecum and proximal colon in dimethylhydrazine-treated rats

PMID:9482760 · one of two readings recorded this

disaccharidase (maltase, sucrase, maltitol-hydrolysing) activity in rat small intestine, cecum and colon

no effect

Not recorded as a finding: this platform holds no node for the endpoint

However, maltase activity in the cecum and colon was not lowered by maltitol ingestion, although it decreased significantly in the cecum of the glucomannan group (p < 0.01).

PMID:9591235 · one of two readings recorded this

maltase activity

decreases, p = 0.01

maltase activity in the cecum and colon was not lowered by maltitol ingestion, although it decreased significantly in the cecum of the glucomannan group (p < 0.01)

PMID:9591235 · one of two readings recorded this

maltase activity

no effect

maltase activity in the cecum and colon was not lowered by maltitol ingestion, although it decreased significantly in the cecum of the glucomannan group (p < 0.01)

PMID:9591235 · one of two readings recorded this

maltase specific activity

decreases, p = 0.01

The specific activity of maltase decreased significantly in the small intestine of the maltitol (p < 0.05) and glucomannan (p < 0.01) groups

PMID:9591235 · one of two readings recorded this

maltase specific activity

decreases, p = 0.05

The specific activity of maltase decreased significantly in the small intestine of the maltitol (p < 0.05) and glucomannan (p < 0.01) groups

PMID:9591235 · one of two readings recorded this

maltase, sucrase and maltitol-hydrolysing disaccharidase specific activity in rat small intestine, cecum and colon mucosa; cecal and colonic tissue weight

decreases

Not recorded as a finding: this platform holds no node for the endpoint

Sucrase activity in the small intestine and cecum was decreased significantly by maltitol (p < 0.05, p < 0.01) or glucomannan (p < 0.01, p < 0.01) ingestion, whereas it was not decreased in the colon.

PMID:9591235 · one of two readings recorded this

maltitol hydrolyzing activity

no effect

Maltitol hydrolyzing activity did not decrease significantly in the small intestine of the maltitol group

PMID:9591235 · one of two readings recorded this

sucrase activity

decreases, p = 0.01

Sucrase activity in the small intestine and cecum was decreased significantly by maltitol (p < 0.05, p < 0.01) or glucomannan (p < 0.01, p < 0.01) ingestion, whereas it was not decreased in the colon

PMID:9591235 · one of two readings recorded this

sucrase activity

no effect

Sucrase activity in the small intestine and cecum was decreased significantly by maltitol (p < 0.05, p < 0.01) or glucomannan (p < 0.01, p < 0.01) ingestion, whereas it was not decreased in the colon

PMID:9591235 · one of two readings recorded this

sucrase activity

decreases, p = 0.05

Sucrase activity in the small intestine and cecum was decreased significantly by maltitol (p < 0.05, p < 0.01) or glucomannan (p < 0.01, p < 0.01) ingestion, whereas it was not decreased in the colon

PMID:9591235 · one of two readings recorded this

tissue weight

increases, p = 0.01

The tissue weights of the cecum and colon increased significantly in both the maltitol (p < 0.01, p < 0.05) and glucomannan (p < 0.01, p < 0.05) groups in comparison with that of the control group

PMID:9591235 · one of two readings recorded this

tissue weight

increases, p = 0.01

The tissue weights of the cecum and colon increased significantly in both the maltitol (p < 0.01, p < 0.05) and glucomannan (p < 0.01, p < 0.05) groups in comparison with that of the control group

PMID:9591235 · one of two readings recorded this