Compound
prostaglandin A2
A prostaglandin carboxylic acid anion resulting from the removal of the proton from the carboxy group of prostaglandin A2.
Definition from ChEBI (CHEBI:133370), read 2026-09-23. CC BY 4.0.
Structure
Loading the model…
- Class
- Organic compound, anion
- Formula
- C20H29O4
- Mass
- 333.448 g/mol
- Charge
- -1
- InChIKey
- MYHXHCUNDDAEOZ-FOSBLDSVSA-M
- SMILES
- CCCCC[C@H](O)/C=C/[C@H]1C=CC(=O)[C@@H]1C/C=CCCCC(=O)[O-]
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
23 entities
23 entities reached.
0 reported hops23 assembled from the scaffold
- GSTP1ProteinUNIPROT:P09211metabolized byInferred only88 paths44 endpoints
- GSTM1ProteinUNIPROT:P09488metabolized byInferred only57 paths19 endpoints
- GSTA1ProteinUNIPROT:P08263metabolized byInferred only54 paths27 endpoints
- MGST1ProteinUNIPROT:P10620substrate ofInferred only45 paths15 endpoints
- GSTZ1ProteinUNIPROT:O43708metabolized byInferred only30 paths15 endpoints
- GSTM4ProteinUNIPROT:Q03013metabolized byInferred only26 paths26 endpoints
- GSTA2ProteinUNIPROT:P09210metabolized byInferred only23 paths23 endpoints
- MGST3ProteinUNIPROT:O14880substrate ofInferred only22 paths11 endpoints
- GSTO1ProteinUNIPROT:P78417metabolized byInferred only22 paths22 endpoints
- MGST2ProteinUNIPROT:Q99735substrate ofInferred only20 paths10 endpoints
- GSTA3ProteinUNIPROT:Q16772metabolized byInferred only14 paths14 endpoints
- SLCO2A1ProteinUNIPROT:Q92959transported byInferred only14 paths13 endpoints
Show the remaining 11
- GSTK1ProteinUNIPROT:Q9Y2Q3metabolized byInferred only14 paths7 endpoints
- PTGESProteinUNIPROT:O14684substrate ofInferred only13 paths13 endpoints
- GSTM3ProteinUNIPROT:P21266metabolized byInferred only13 paths13 endpoints
- GSTM2ProteinUNIPROT:P28161metabolized byInferred only12 paths12 endpoints
- HPGDSProteinUNIPROT:O60760substrate ofInferred only11 paths11 endpoints
- GSTA4ProteinUNIPROT:O15217metabolized byInferred only9 paths9 endpoints
- GSTM5ProteinUNIPROT:P46439metabolized byInferred only9 paths9 endpoints
- GSTA5ProteinUNIPROT:Q7RTV2metabolized byInferred only9 paths9 endpoints
- GSTO2ProteinUNIPROT:Q9H4Y5metabolized byInferred only9 paths9 endpoints
- SLCO1B1ProteinUNIPROT:Q9Y6L6transported byInferred only9 paths2 endpoints
- GSTT2BProteinUNIPROT:P0CG30metabolized byInferred only6 paths6 endpoints
What the reference databases state
Chemical structure
- prostaglandin A2-S-(R)-glutathione has the functional parent prostaglandin A2CompoundChEBI CHEBI:133768Inferred only
- prostaglandin A2-S-(S)-glutathione has the functional parent prostaglandin A2CompoundChEBI CHEBI:133769Inferred only
Statements
40 statements
40 statements · 2 reference databases · Subject: prostaglandin A2 · Sources: Human-GEM, Rhea
- prostaglandin A2 is converted to prostaglandin E2CompoundHuman-GEM MAR03016Inferred only
- prostaglandin E2 is converted to prostaglandin A2CompoundHuman-GEM MAR01321Inferred only
- prostaglandin E2 is converted to prostaglandin A2CompoundHuman-GEM MAR03016Inferred only
- prostaglandin A2 is converted to prostaglandin E2CompoundHuman-GEM MAR01321Inferred only
- prostaglandin A2 is metabolised by GSTA1ProteinRhea RHEA:50796Inferred only
- prostaglandin A2 is metabolised by GSTA1ProteinHuman-GEM MAR01370Inferred only
- prostaglandin A2 is metabolised by GSTA2ProteinHuman-GEM MAR01370Inferred only
- prostaglandin A2 is metabolised by GSTA3ProteinHuman-GEM MAR01370Inferred only
- prostaglandin A2 is metabolised by GSTA4ProteinHuman-GEM MAR01370Inferred only
- prostaglandin A2 is metabolised by GSTA5ProteinHuman-GEM MAR01370Inferred only
- prostaglandin A2 is metabolised by GSTK1ProteinHuman-GEM MAR03963Inferred only
- prostaglandin A2 is metabolised by GSTK1ProteinHuman-GEM MAR01370Inferred only
Show the remaining 28
- prostaglandin A2 is metabolised by GSTM1ProteinHuman-GEM MAR01370Inferred only
- prostaglandin A2 is metabolised by GSTM1ProteinRhea RHEA:50800Inferred only
- prostaglandin A2 is metabolised by GSTM1ProteinRhea RHEA:50796Inferred only
- prostaglandin A2 is metabolised by GSTM2ProteinHuman-GEM MAR01370Inferred only
- prostaglandin A2 is metabolised by GSTM3ProteinHuman-GEM MAR01370Inferred only
- prostaglandin A2 is metabolised by GSTM4ProteinHuman-GEM MAR01370Inferred only
- prostaglandin A2 is metabolised by GSTM5ProteinHuman-GEM MAR01370Inferred only
- prostaglandin A2 is metabolised by GSTO1ProteinHuman-GEM MAR01370Inferred only
- prostaglandin A2 is metabolised by GSTO2ProteinHuman-GEM MAR01370Inferred only
- prostaglandin A2 is metabolised by GSTP1ProteinRhea RHEA:50800Inferred only
- prostaglandin A2 is metabolised by GSTP1ProteinHuman-GEM MAR01370Inferred only
- prostaglandin A2 is metabolised by GSTT2BProteinHuman-GEM MAR01370Inferred only
- prostaglandin A2 is metabolised by GSTZ1ProteinHuman-GEM MAR03963Inferred only
- prostaglandin A2 is metabolised by GSTZ1ProteinHuman-GEM MAR01370Inferred only
- prostaglandin A2 is a substrate of HPGDSProteinHuman-GEM MAR01370Inferred only
- prostaglandin A2 is a substrate of MGST1ProteinHuman-GEM MAR03973Inferred only
- prostaglandin A2 is a substrate of MGST1ProteinHuman-GEM MAR03963Inferred only
- prostaglandin A2 is a substrate of MGST1ProteinHuman-GEM MAR01370Inferred only
- prostaglandin A2 is a substrate of MGST2ProteinHuman-GEM MAR03973Inferred only
- prostaglandin A2 is a substrate of MGST2ProteinHuman-GEM MAR01370Inferred only
- prostaglandin A2 is a substrate of MGST3ProteinHuman-GEM MAR01370Inferred only
- prostaglandin A2 is a substrate of MGST3ProteinHuman-GEM MAR03973Inferred only
- prostaglandin A2 is a substrate of PTGESProteinHuman-GEM MAR01370Inferred only
- prostaglandin A2 is a substrate of SCARF2ProteinHuman-GEM MAR01321Inferred only
- prostaglandin A2 is transported by SLCO1B1ProteinHuman-GEM MAR06168Inferred only
- prostaglandin A2 is transported by SLCO1B1ProteinHuman-GEM MAR06167Inferred only
- prostaglandin A2 is transported by SLCO1B1ProteinHuman-GEM MAR06166Inferred only
- prostaglandin A2 is transported by SLCO2A1ProteinHuman-GEM MAR06225Inferred only
Reactions
19 reactions
water+prostaglandin A2prostaglandin E2
Catalysed by SCARF2
Reaction pageReversibleBalancedEC 4.2.1.-GO:0005829
Human-GEM MAR01321CC BY 4.0Reference data
prostaglandin A2MAM02781c
Reaction pageReversibleBalancedEC 5.3.-.-GO:0005829
Human-GEM MAR01322CC BY 4.0Reference data
CHEBI:16856+prostaglandin A2MAM02863c
Catalysed by MGST1 or GSTO2 or GSTP1 or MGST2 or GSTZ1 or GSTT2B or GSTM1 or GSTM5 or GSTM3 or MGST3 or PTGES or GSTO1 and 9 more alternatives
Reaction pageReversibleBalancedEC 2.5.1.18GO:0005829
Human-GEM MAR01370CC BY 4.0Reference data
prostaglandin E2water+prostaglandin A2
Reaction pageReversibleBalancedGO:0005759
Human-GEM MAR03016CC BY 4.0Reference data
CHEBI:16856+prostaglandin A2MAM02863m
Catalysed by MGST1 or GSTZ1 or GSTK1
Reaction pageReversibleBalancedEC 2.5.1.18GO:0005759
Human-GEM MAR03963CC BY 4.0Reference data
CHEBI:16856+prostaglandin A2MAM02863r
Catalysed by MGST1 or MGST2 or MGST3
Reaction pageReversibleBalancedEC 2.5.1.18GO:0005783
Human-GEM MAR03973CC BY 4.0Reference data
Reaction pageReversibleBalance undeterminableGO:0005615
Human-GEM MAR04213CC BY 4.0Reference data
MAM01980c+hydrogencarbonate+prostaglandin A2MAM01980e+hydrogencarbonate+prostaglandin A2
Transported by SLCO1B1
Reaction pageReversibleBalance undeterminableGO:0005829, GO:0005615
Human-GEM MAR06166CC BY 4.0Reference data
hydrogencarbonate+prostaglandin A2+2,4-dinitrophenyl-S-glutathionehydrogencarbonate+prostaglandin A2+2,4-dinitrophenyl-S-glutathione
Transported by SLCO1B1
Reaction pageReversibleBalancedGO:0005829, GO:0005615
Human-GEM MAR06167CC BY 4.0Reference data
hydrogencarbonate+prostaglandin A2+MAM02901chydrogencarbonate+prostaglandin A2+MAM02901e
Transported by SLCO1B1
Reaction pageReversibleBalancedGO:0005829, GO:0005615
Human-GEM MAR06168CC BY 4.0Reference data
CHEBI:16856+hydrogencarbonate+prostaglandin A2CHEBI:16856+hydrogencarbonate+prostaglandin A2
Transported by SLCO2A1
Reaction pageReversibleBalancedGO:0005829, GO:0005615
Human-GEM MAR06225CC BY 4.0Reference data
prostaglandin A2prostaglandin A2
Reaction pageReversibleBalancedGO:0005829, GO:0005615
Human-GEM MAR06260CC BY 4.0Reference data
Where it reaches
5 systems, 8 regions, 15 tissues, 15 transporter routes — routes, not measurements: transporters known to carry prostaglandin A2 are expressed there, and no source reports it arriving.
Loading the model…
Other names
4 names
Resolves to: prostaglandin A2
- Also called
- (5E)-7-{2-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-5-oxocyclopent-3-en-1-yl}hept-5-enoatePGA2prostaglandin 2
- Systematic name
- (5Z,13E,15S)-15-hydroxy-9-oxoprosta-5,10,13-trien-1-oate