Compound

N-acetyl-beta-neuraminic acid

N-Acetylneuraminic acid with β configuration at the anomeric centre.

Definition from ChEBI (CHEBI:45744), read 2026-09-23. CC BY 4.0.

CHEBI:45744ChEBI

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What it touches on the way

Mechanistic reach

3 entities

3 entities reached.

0 reported hops3 assembled from the scaffold

What the reference databases state

Statements

9 statements

9 statements · 1 reference database · Subject: N-acetyl-beta-neuraminic acid · Sources: Human-GEM

Order

a ganglioside GM1 (d18:1(4E)) is converted to N-acetyl-beta-neuraminic acidCompoundHuman-GEM MAR12068Inferred only
N-acetyl-beta-neuraminic acid is converted to CMP-N-acetyl-beta-neuraminateCompoundHuman-GEM MAR08377Inferred only
N-acetyl-beta-neuraminic acid is converted to CMP-N-acetyl-beta-neuraminateCompoundHuman-GEM MAR04536Inferred only
N-acetylneuraminate 9-phosphate is converted to N-acetyl-beta-neuraminic acidCompoundHuman-GEM MAR04530Inferred only
N-acetyl-beta-neuraminic acid is converted to N-glycoloylneuraminateCompoundHuman-GEM MAR04531Inferred only
N-acetyl-beta-neuraminic acid is a substrate of CMASProteinHuman-GEM MAR08377Inferred only
N-acetyl-beta-neuraminic acid is a substrate of CMASProteinHuman-GEM MAR04536Inferred only
N-acetyl-beta-neuraminic acid is a substrate of NPLProteinHuman-GEM MAR08373Inferred only
N-acetyl-beta-neuraminic acid is transported by SLC17A5ProteinHuman-GEM MAR07196Inferred only

Reactions

39 reactions

a ganglioside GM3 (d18:1(4E))+watera beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))+N-acetyl-beta-neuraminic acid
Catalysed by NEU2 or NEU3 or NEU4 or NEU1
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.18GO:0005829
Human-GEM MAR00825CC BY 4.0Reference data
a ganglioside GM3 (d18:1(4E))+watera beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))+N-acetyl-beta-neuraminic acid
Catalysed by NEU2 or NEU3 or NEU4 or NEU1
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.18GO:0005764
Human-GEM MAR00826CC BY 4.0Reference data
water+a ganglioside GM4 (d18:1(4E))CHEBI:12947+proton+N-acetyl-beta-neuraminic acid
Catalysed by NEU2 or NEU3 or NEU4 or NEU1
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.18GO:0005764
Human-GEM MAR00834CC BY 4.0Reference data
a ganglioside GD1a (d18:1(4E))+watera ganglioside GM1 (d18:1(4E))+N-acetyl-beta-neuraminic acid
Catalysed by NEU2 or NEU3 or NEU4 or NEU1
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.18GO:0005829
Human-GEM MAR00838CC BY 4.0Reference data
a ganglioside GT1b (d18:1(4E))+watera ganglioside GD1b (d18:1(4E))+N-acetyl-beta-neuraminic acid
Catalysed by NEU2 or NEU3 or NEU4 or NEU1
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.18GO:0005829
Human-GEM MAR00845CC BY 4.0Reference data
a ganglioside GQ1b (d18:1(4E))+watera ganglioside GT1b (d18:1(4E))+N-acetyl-beta-neuraminic acid
Catalysed by NEU2 or NEU3 or NEU4 or NEU1
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.18GO:0005829
Human-GEM MAR00847CC BY 4.0Reference data
a ganglioside GM2 (d18:1(4E))+watera ganglioside GA2 (d18:1(4E))+N-acetyl-beta-neuraminic acid
Catalysed by NEU2 or NEU3 or NEU4 or NEU1
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.18GO:0005829
Human-GEM MAR00850CC BY 4.0Reference data
MAM01653c+2waterMAM02324c+2N-acetyl-beta-neuraminic acid
Catalysed by NEU2 or NEU4
Reaction pageLeft to rightBalancedEC 3.2.1.18GO:0005829
Human-GEM MAR01713CC BY 4.0Reference data
water+N-acetylneuraminate 9-phosphateN-acetyl-beta-neuraminic acid+phosphate(3-)
Catalysed by NANP
Reaction pageLeft to rightBalancedEC 3.1.3.29GO:0005829
Human-GEM MAR04530CC BY 4.0Reference data
proton+N-acetyl-beta-neuraminic acid+NADH(2-)+dioxygenwater+NAD(+)+N-glycoloylneuraminate
Reaction pageLeft to rightBalancedEC 1.14.18.2GO:0005829
Human-GEM MAR04531CC BY 4.0Reference data
CHEBI:17677+N-acetyl-beta-neuraminic acidCMP-N-acetyl-beta-neuraminate+diphosphate(3-)
Catalysed by CMAS
Reaction pageLeft to rightBalancedEC 2.7.7.43GO:0005634
Human-GEM MAR04536CC BY 4.0Reference data
N-acetyl-beta-neuraminic acidN-acetyl-beta-neuraminic acid
Reaction pageReversibleBalancedGO:0005829, GO:0005634
Human-GEM MAR05424CC BY 4.0Reference data

Show the remaining 27

Where it reaches

1 system, 1 region, 1 tissue, 1 transporter route — routes, not measurements: transporters known to carry N-acetyl-beta-neuraminic acid are expressed there, and no source reports it arriving.

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Reproductive

Other names

9 names

Resolves to: N-acetyl-beta-neuraminic acid

Also called: 5-(acetylamino)-3,5-dideoxy-D-glycero-beta-D-galacto-2-nonulopyranosonic acid5-(acetylamino)-3,5-dideoxy-D-glycero-β-D-galacto-2-nonulopyranosonic acid5-N-ACETYL-BETA-D-NEURAMINIC ACIDbeta-Neu5AcD-glycero-beta-D-galacto-2-nonulopyranosonic acid, 5-(acetylamino)-3,5-dideoxy-D-glycero-β-D-galacto-2-nonulopyranosonic acid, 5-(acetylamino)-3,5-dideoxy-β-Neu5Ac
Systematic name: 5-acetamido-3,5-dideoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonic acid5-acetamido-3,5-dideoxy-D-glycero-β-D-galacto-non-2-ulopyranosonic acid