Compound
CHEBI:15746
A biogenic polyamine formed from spermidine. It is found in a wide variety of organisms and tissues and is an essential growth factor in some bacteria. It is found as a polycation at all pH values. Spermine is associated with nucleic acids, particularly in viruses, and is thought to stabilize the helical structure.
What it touches on the way
Mechanistic reach
6 entities
6 entities reached.
0 reported hops6 assembled from the scaffold
- SAT1ProteinUNIPROT:P21673substrate ofInferred only108 paths54 endpoints
- AOC1ProteinUNIPROT:P19801substrate ofInferred only36 paths12 endpoints
- AOC3ProteinUNIPROT:Q16853substrate ofInferred only15 paths5 endpoints
- AOC2ProteinUNIPROT:O75106substrate ofInferred only9 paths3 endpoints
- SLC22A1ProteinUNIPROT:O15245transported byInferred only3 paths3 endpoints
- SAT2ProteinUNIPROT:Q96F10substrate ofInferred only2 paths1 endpoint
What the reference databases state
Statements
18 statements
18 statements · 1 reference database · Subject: CHEBI:15746 · Sources: Human-GEM
- CHEBI:15746 is converted to spermine monoaldehydeCompoundHuman-GEM MAR06933Inferred only
- CHEBI:15746 is converted to spermine monoaldehydeCompoundHuman-GEM MAR06931Inferred only
- CHEBI:15746 is converted to spermine monoaldehydeCompoundHuman-GEM MAR06932Inferred only
- CHEBI:15746 is a substrate of AOC1ProteinHuman-GEM MAR06932Inferred only
- CHEBI:15746 is a substrate of AOC1ProteinHuman-GEM MAR06931Inferred only
- CHEBI:15746 is a substrate of AOC1ProteinHuman-GEM MAR06933Inferred only
- CHEBI:15746 is a substrate of AOC2ProteinHuman-GEM MAR06932Inferred only
- CHEBI:15746 is a substrate of AOC2ProteinHuman-GEM MAR06931Inferred only
- CHEBI:15746 is a substrate of AOC2ProteinHuman-GEM MAR06933Inferred only
- CHEBI:15746 is a substrate of AOC3ProteinHuman-GEM MAR06931Inferred only
- CHEBI:15746 is a substrate of AOC3ProteinHuman-GEM MAR06933Inferred only
- CHEBI:15746 is a substrate of AOC3ProteinHuman-GEM MAR06932Inferred only
Show the remaining 6
- CHEBI:15746 is a substrate of SAT1ProteinHuman-GEM MAR06930Inferred only
- CHEBI:15746 is a substrate of SAT1ProteinHuman-GEM MAR06929Inferred only
- CHEBI:15746 is a substrate of SAT2ProteinHuman-GEM MAR06929Inferred only
- CHEBI:15746 is a substrate of SAT2ProteinHuman-GEM MAR06930Inferred only
- CHEBI:15746 is a substrate of SMOXProteinHuman-GEM MAR04078Inferred only
- CHEBI:15746 is transported by SLC22A1ProteinHuman-GEM MAR05013Inferred only
Reactions
11 reactions
S-adenosylmethioninamine+spermidineS-methyl-5'-thioadenosine+proton+CHEBI:15746
Reaction pageLeft to rightBalancedEC 2.5.1.16, 2.5.1.22cytosol
Human-GEM MAR04077CC BY 4.0Reference data
water+dioxygen+CHEBI:157463-aminopropanal+hydrogen peroxide+spermidine
Catalysed by SMOX
Reaction pageLeft to rightBalancedEC 1.5.3.17cytosol
Human-GEM MAR04078CC BY 4.0Reference data
Transported by SLC22A1
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR05013CC BY 4.0Reference data
Reaction pageReversibleBalancedcytosol, peroxisome
Human-GEM MAR06928CC BY 4.0Reference data
CHEBI:1146900+proton+CHEBI:17312CHEBI:15351+CHEBI:15746
Reaction pageReversibleBalancedEC 2.3.1.57cytosol
Human-GEM MAR06929CC BY 4.0Reference data
CHEBI:1146900+proton+CHEBI:17312CHEBI:15351+CHEBI:15746
Reaction pageReversibleBalancedEC 2.3.1.57peroxisome
Human-GEM MAR06930CC BY 4.0Reference data
water+dioxygen+CHEBI:15746proton+hydrogen peroxide+ammonium+spermine monoaldehyde
Catalysed by AOC1 or AOC3 or AOC2
Reaction pageLeft to rightBalancedEC 1.4.3.21, 1.4.3.22cytosol
Human-GEM MAR06931CC BY 4.0Reference data
water+dioxygen+CHEBI:15746proton+hydrogen peroxide+ammonium+spermine monoaldehyde
Catalysed by AOC1 or AOC3 or AOC2
Reaction pageLeft to rightBalancedEC 1.4.3.21, 1.4.3.22extracellular space
Human-GEM MAR06932CC BY 4.0Reference data
FAD+water+CHEBI:15746FADH2+proton+ammonium+spermine monoaldehyde
Catalysed by AOC1 or AOC3 or AOC2
Reaction pageLeft to rightBalancedEC 1.4.3.21, 1.4.3.22peroxisome
Human-GEM MAR06933CC BY 4.0Reference data
Reaction pageReversibleBalance undeterminableextracellular space
Human-GEM MAR09715CC BY 4.0Reference data
proton+CHEBI:15746proton+CHEBI:15746
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR11317CC BY 4.0Reference data
Where it reaches
1 system, 1 region, 2 tissues, 2 transporter routes — routes, not measurements: transporters known to carry CHEBI:15746 are expressed there, and no source reports it arriving.
Loading the model…
Other names
5 names
Resolves to: CHEBI:15746
- Also called
- 4,9-diaza-1,12-dodecanediamine4,9-diazadodecane-1,12-diamineN,N'-Bis(3-aminopropyl)-1,4-butanediamineSpermine
- Systematic name
- N,N'-bis(3-aminopropyl)butane-1,4-diamine