Compound
serotonin
A biochemical messenger and regulator, synthesized from the essential amino acid l-tryptophan. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (receptors, serotonin) explain the broad physiological actions and distribution of this biochemical mediator.
Structure
No depiction stored
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- Class
- Organic compound, cation
- Formula
- C10H13N2O
- Mass
- 177.227 g/mol
- Charge
- +1
- InChIKey
- QZAYGJVTTNCVMB-UHFFFAOYSA-O
- SMILES
- [NH3+]CCc1cnc2ccc(O)cc12
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
20 entities
20 entities reached.
0 reported hops20 assembled from the scaffold
- MAOAProteinUNIPROT:P21397metabolized byInferred only72 paths36 endpoints
- TGM2ProteinUNIPROT:P21980substrate ofInferred only28 paths24 endpoints
- SLC6A4ProteinUNIPROT:P31645transported byInferred only20 paths10 endpoints
- DDCProteinUNIPROT:P20711substrate ofInferred only19 paths19 endpoints
- SULT1A3ProteinUNIPROT:P0DMM9metabolized byInferred only15 paths15 endpoints
- IDO1ProteinUNIPROT:P14902substrate ofInferred only15 paths15 endpoints
- MAOBProteinUNIPROT:P27338metabolized byInferred only13 paths13 endpoints
- SLCO1B3ProteinUNIPROT:Q9NPD5transported byInferred only12 paths2 endpoints
- AANATProteinUNIPROT:Q16613substrate ofInferred only11 paths11 endpoints
- SLC22A2ProteinUNIPROT:O15244transported byInferred only10 paths5 endpoints
- SLC22A3ProteinUNIPROT:O75751transported byInferred only8 paths4 endpoints
- SULT1A4ProteinUNIPROT:P0DMN0metabolized byInferred only8 paths8 endpoints
Show the remaining 8
- SLC18A2ProteinUNIPROT:Q05940transported byInferred only7 paths7 endpoints
- IDO2ProteinUNIPROT:Q6ZQW0substrate ofInferred only7 paths7 endpoints
- INMTProteinUNIPROT:O95050substrate ofInferred only7 paths7 endpoints
- SLC22A1ProteinUNIPROT:O15245transported byInferred only6 paths3 endpoints
- SLC18A1ProteinUNIPROT:P54219transported byInferred only6 paths6 endpoints
- 5-hydroxy-L-tryptophanCompoundCHEBI:17780converted toInferred only5 paths4 endpoints
- SLC29A4ProteinUNIPROT:Q7RTT9transported byInferred only3 paths1 endpoint
- SLC18B1ProteinUNIPROT:Q6NT16transported byInferred only1 path1 endpoint
What the reference databases state
Statements
45 statements
45 statements · 2 reference databases · Subject: serotonin · Sources: Human-GEM, Rhea
- serotonin is converted to (5-hydroxyindol-3-yl)acetaldehydeCompoundRhea RHEA:69072Inferred only
- serotonin is converted to (5-hydroxyindol-3-yl)acetaldehydeCompoundHuman-GEM MAR04558Inferred only
- (5-hydroxyindol-3-yl)acetaldehyde is converted to serotoninCompoundRhea RHEA:69072Inferred only
- serotonin is converted to 5-hydroxy-L-tryptophanCompoundRhea RHEA:18533Inferred only
- 5-hydroxy-L-tryptophan is converted to serotoninCompoundRhea RHEA:18533Inferred only
- 5-hydroxytryptophan is converted to serotoninCompoundHuman-GEM MAR04545Inferred only
- N-acetylserotonin is converted to serotoninCompoundRhea RHEA:25217Inferred only
- serotonin is converted to N-acetylserotoninCompoundRhea RHEA:25217Inferred only
- serotonin is converted to N-methylserotoninCompoundHuman-GEM MAR04555Inferred only
- serotonin is converted to serotonin O-sulfateCompoundRhea RHEA:83339Inferred only
- serotonin is metabolised by MAOAProteinRhea RHEA:69072Inferred only
- serotonin is metabolised by MAOAProteinHuman-GEM MAR04558Inferred only
Show the remaining 33
- serotonin is metabolised by MAOBProteinHuman-GEM MAR04558Inferred only
- serotonin is metabolised by SULT1A3ProteinRhea RHEA:83339Inferred only
- serotonin is metabolised by SULT1A4ProteinRhea RHEA:83339Inferred only
- serotonin is a substrate of AANATProteinHuman-GEM MAR04546Inferred only
- serotonin is a substrate of DDCProteinRhea RHEA:18533Inferred only
- serotonin is a substrate of IDO1ProteinHuman-GEM MAR04557Inferred only
- serotonin is a substrate of IDO2ProteinHuman-GEM MAR04557Inferred only
- serotonin is a substrate of INMTProteinHuman-GEM MAR04555Inferred only
- serotonin is a substrate of TGM2ProteinRhea RHEA:66552Inferred only
- serotonin is transported by SLC18A1ProteinRhea RHEA:73743Inferred only
- serotonin is transported by SLC18A2ProteinRhea RHEA:73743Inferred only
- serotonin is transported by SLC18A3ProteinRhea RHEA:73743Inferred only
- serotonin is transported by SLC18B1ProteinRhea RHEA:74295Inferred only
- serotonin is transported by SLC22A1ProteinRhea RHEA:73867Inferred only
- serotonin is transported by SLC22A1ProteinHuman-GEM MAR06243Inferred only
- serotonin is transported by SLC22A2ProteinHuman-GEM MAR06243Inferred only
- serotonin is transported by SLC22A2ProteinRhea RHEA:73867Inferred only
- serotonin is transported by SLC22A3ProteinHuman-GEM MAR06243Inferred only
- serotonin is transported by SLC22A3ProteinRhea RHEA:73867Inferred only
- serotonin is transported by SLC29A3ProteinRhea RHEA:73867Inferred only
- serotonin is transported by SLC29A4ProteinHuman-GEM MAR09905Inferred only
- serotonin is transported by SLC29A4ProteinRhea RHEA:73867Inferred only
- serotonin is transported by SLC29A4ProteinHuman-GEM MAR06243Inferred only
- serotonin is transported by SLC6A4ProteinRhea RHEA:75839Inferred only
- serotonin is transported by SLC6A4ProteinHuman-GEM MAR06244Inferred only
- serotonin is transported by SLCO1A2ProteinHuman-GEM MAR06215Inferred only
- serotonin is transported by SLCO1A2ProteinHuman-GEM MAR01901Inferred only
- serotonin is transported by SLCO1A2ProteinHuman-GEM MAR01903Inferred only
- serotonin is transported by SLCO1A2ProteinHuman-GEM MAR01902Inferred only
- serotonin is transported by SLCO1B3ProteinHuman-GEM MAR06215Inferred only
- serotonin is transported by SLCO1B3ProteinHuman-GEM MAR01901Inferred only
- serotonin is transported by SLCO1B3ProteinHuman-GEM MAR01902Inferred only
- serotonin is transported by SLCO1B3ProteinHuman-GEM MAR01903Inferred only
Reactions
34 reactions
MAM01980c+hydrogencarbonate+serotoninMAM01980e+hydrogencarbonate+serotonin
Transported by SLCO1A2 or SLCO1B3
Reaction pageReversibleBalance undeterminablecytosol, extracellular space
Human-GEM MAR01901CC BY 4.0Reference data
hydrogencarbonate+serotonin+2,4-dinitrophenyl-S-glutathionehydrogencarbonate+serotonin+2,4-dinitrophenyl-S-glutathione
Transported by SLCO1A2 or SLCO1B3
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR01902CC BY 4.0Reference data
hydrogencarbonate+serotonin+MAM02901chydrogencarbonate+serotonin+MAM02901e
Transported by SLCO1A2 or SLCO1B3
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR01903CC BY 4.0Reference data
5-hydroxytryptophan+protoncarbon dioxide+serotonin
Catalysed by DDC
Reaction pageLeft to rightBalancedEC 4.1.1.28cytosol
Human-GEM MAR04545CC BY 4.0Reference data
CHEBI:15351+serotoninCHEBI:1146900+proton+N-acetylserotonin
Catalysed by AANAT
Reaction pageLeft to rightBalancedEC 2.3.1.87cytosol
Human-GEM MAR04546CC BY 4.0Reference data
MAM01160c+waterformaldehyde+serotonin
Reaction pageReversibleBalancedcytosol
Human-GEM MAR04554CC BY 4.0Reference data
S-adenosyl-L-methionine+serotoninproton+N-methylserotonin+CHEBI:16680
Catalysed by INMT
Reaction pageLeft to rightBalancedEC 2.1.1.49cytosol
Human-GEM MAR04555CC BY 4.0Reference data
Reaction pageLeft to rightBalancedEC 1.13.11.52cytosol
Human-GEM MAR04557CC BY 4.0Reference data
water+dioxygen+serotonin(5-hydroxyindol-3-yl)acetaldehyde+proton+hydrogen peroxide+ammonium
Reaction pageLeft to rightBalancedEC 1.4.3.4cytosol
Human-GEM MAR04558CC BY 4.0Reference data
CHEBI:16856+hydrogencarbonate+serotoninCHEBI:16856+hydrogencarbonate+serotonin
Transported by SLCO1A2 & SLCO1B3
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR06215CC BY 4.0Reference data
Transported by SLC22A2 or SLC22A3 or SLC29A4 or SLC22A1
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR06243CC BY 4.0Reference data
2potassium atom+2sodium(1+)+serotonin2potassium atom+2sodium(1+)+serotonin
Transported by SLC6A4
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR06244CC BY 4.0Reference data
Where it reaches
7 systems, 12 regions, 22 tissues, 26 transporter routes — routes, not measurements: transporters known to carry serotonin are expressed there, and no source reports it arriving.
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Other names
2 names
Resolves to: serotonin
- Also called
- serotonin cation
- Systematic name
- 2-(5-hydroxy-1H-indol-3-yl)ethanaminium