Compound
acetate
A monocarboxylic acid anion resulting from the removal of a proton from the carboxy group of acetic acid.
Definition from ChEBI (CHEBI:30089), read 2026-09-23. CC BY 4.0.
What it touches on the way
Mechanistic reach
31 entities
31 entities reached.
0 reported hops31 assembled from the scaffold
- SLC16A1ProteinUNIPROT:P53985transported byInferred only275 paths25 endpoints
- SIRT7ProteinUNIPROT:Q9NRC8substrate ofInferred only114 paths113 endpoints
- HDAC10ProteinUNIPROT:Q969S8substrate ofInferred only75 paths25 endpoints
- SIRT1ProteinUNIPROT:Q96EB6substrate ofInferred only72 paths72 endpoints
- ACY1ProteinUNIPROT:Q03154substrate ofInferred only60 paths20 endpoints
- SLC16A7ProteinUNIPROT:O60669transported byInferred only60 paths6 endpoints
- CYP17A1ProteinUNIPROT:P05093metabolized byInferred only56 paths28 endpoints
- ACSS2ProteinUNIPROT:Q9NR19substrate ofInferred only39 paths13 endpoints
- ASAH1ProteinUNIPROT:Q13510substrate ofInferred only26 paths26 endpoints
- SIRT3ProteinUNIPROT:Q9NTG7substrate ofInferred only21 paths21 endpoints
- SLC16A3ProteinUNIPROT:O15427transported byInferred only21 paths7 endpoints
- ACSS3ProteinUNIPROT:Q9H6R3substrate ofInferred only20 paths10 endpoints
Show the remaining 19
- CES1ProteinUNIPROT:P23141metabolized byInferred only20 paths20 endpoints
- ACSS1ProteinUNIPROT:Q9NUB1substrate ofInferred only18 paths9 endpoints
- SIRT6ProteinUNIPROT:Q8N6T7substrate ofInferred only16 paths16 endpoints
- SIRT2ProteinUNIPROT:Q8IXJ6substrate ofInferred only14 paths14 endpoints
- CES2ProteinUNIPROT:O00748metabolized byInferred only12 paths12 endpoints
- PON2ProteinUNIPROT:Q15165substrate ofInferred only11 paths11 endpoints
- SIRT5ProteinUNIPROT:Q9NXA8substrate ofInferred only10 paths10 endpoints
- PON3ProteinUNIPROT:Q15166substrate ofInferred only9 paths9 endpoints
- ACY3ProteinUNIPROT:Q96HD9substrate ofInferred only9 paths3 endpoints
- PON1ProteinUNIPROT:P27169substrate ofInferred only9 paths9 endpoints
- ESDProteinUNIPROT:P10768substrate ofInferred only8 paths8 endpoints
- AMDHD2ProteinUNIPROT:Q9Y303substrate ofInferred only6 paths6 endpoints
- ASPAProteinUNIPROT:P45381substrate ofInferred only4 paths4 endpoints
- NAAAProteinUNIPROT:Q02083substrate ofInferred only3 paths3 endpoints
- FAHD1ProteinUNIPROT:Q6P587substrate ofInferred only3 paths3 endpoints
- DIP2AProteinUNIPROT:Q14689substrate ofInferred only2 paths2 endpoints
- SLC16A8ProteinUNIPROT:O95907transported byInferred only2 paths1 endpoint
- MACROD2ProteinUNIPROT:A1Z1Q3substrate ofInferred only1 path1 endpoint
- MACROD1ProteinUNIPROT:Q9BQ69substrate ofInferred only1 path1 endpoint
What the reference databases state
Chemical structure
- 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate has the functional parent acetateCompoundChEBI CHEBI:78385Inferred only
- glycolate has the functional parent acetateCompoundChEBI CHEBI:29805Inferred only
- homogentisate has the functional parent acetateCompoundChEBI CHEBI:16169Inferred only
Statements
108 statements
108 statements · 3 reference databases · Subject: acetate · Sources: ChEBI, Human-GEM, Rhea
- acetate is converted to (S)-lactateCompoundRhea RHEA:16513Inferred only
- (S)-lactate is converted to acetateCompoundRhea RHEA:16513Inferred only
- acetate is converted to acetaldehydeCompoundRhea RHEA:25298Inferred only
- acetaldehyde is converted to acetateCompoundHuman-GEM MAR01568Inferred only
- acetaldehyde is converted to acetateCompoundHuman-GEM MAR04283Inferred only
- acetaldehyde is converted to acetateCompoundHuman-GEM MAR08357Inferred only
- acetaldehyde is converted to acetateCompoundRhea RHEA:25294Inferred only
- acetaldehyde is converted to acetateCompoundRhea RHEA:25298Inferred only
- malonate is converted to acetateCompoundRhea RHEA:58820Inferred only
- acetate is converted to malonateCompoundRhea RHEA:18817Inferred only
- malonate is converted to acetateCompoundRhea RHEA:18817Inferred only
- acetate is converted to malonateCompoundRhea RHEA:58820Inferred only
Show the remaining 96
- acetate is converted to malonateCompoundRhea RHEA:25896Inferred only
- malonate is converted to acetateCompoundRhea RHEA:25896Inferred only
- potassium acetate is converted to acetateCompoundChEBI CHEBI:32029Inferred only
- acetate is metabolised by CES1ProteinRhea RHEA:12208Inferred only
- acetate is metabolised by CES2ProteinRhea RHEA:12208Inferred only
- acetate is metabolised by CYP17A1ProteinHuman-GEM MAR01987Inferred only
- acetate is metabolised by CYP17A1ProteinHuman-GEM MAR01960Inferred only
- acetate is a substrate of ACSS1ProteinHuman-GEM MAR04099Inferred only
- acetate is a substrate of ACSS1ProteinRhea RHEA:23176Inferred only
- acetate is a substrate of ACSS2ProteinHuman-GEM MAR04133Inferred only
- acetate is a substrate of ACSS2ProteinHuman-GEM MAR04097Inferred only
- acetate is a substrate of ACSS2ProteinRhea RHEA:23176Inferred only
- acetate is a substrate of ACSS3ProteinRhea RHEA:23176Inferred only
- acetate is a substrate of ACSS3ProteinHuman-GEM MAR04099Inferred only
- acetate is a substrate of ACY1ProteinHuman-GEM MAR08425Inferred only
- acetate is a substrate of ACY1ProteinHuman-GEM MAR03919Inferred only
- acetate is a substrate of ACY1ProteinHuman-GEM MAR04199Inferred only
- acetate is a substrate of ACY3ProteinHuman-GEM MAR06969Inferred only
- acetate is a substrate of ACY3ProteinRhea RHEA:36855Inferred only
- acetate is a substrate of ACY3ProteinHuman-GEM MAR05339Inferred only
- acetate is a substrate of AMDHD2ProteinRhea RHEA:22936Inferred only
- acetate is a substrate of ASAH1ProteinRhea RHEA:58484Inferred only
- acetate is a substrate of ASPAProteinHuman-GEM MAR06969Inferred only
- acetate is a substrate of DIP2AProteinRhea RHEA:23176Inferred only
- acetate is a substrate of ESDProteinRhea RHEA:12208Inferred only
- acetate is a substrate of FAHD1ProteinRhea RHEA:16097Inferred only
- acetate is a substrate of HDAC10ProteinRhea RHEA:23928Inferred only
- acetate is a substrate of HDAC10ProteinRhea RHEA:51892Inferred only
- acetate is a substrate of HDAC10ProteinRhea RHEA:23412Inferred only
- acetate is a substrate of MACROD1ProteinHuman-GEM MAR05339Inferred only
- acetate is a substrate of MACROD2ProteinHuman-GEM MAR05339Inferred only
- acetate is a substrate of NAAAProteinHuman-GEM MAR05339Inferred only
- acetate is a substrate of NTAN1ProteinHuman-GEM MAR05339Inferred only
- acetate is a substrate of OARD1ProteinHuman-GEM MAR05339Inferred only
- acetate is a substrate of PON1ProteinRhea RHEA:17309Inferred only
- acetate is a substrate of PON2ProteinRhea RHEA:17309Inferred only
- acetate is a substrate of PON3ProteinRhea RHEA:17309Inferred only
- acetate is a substrate of SIRT1ProteinHuman-GEM MAR05339Inferred only
- acetate is a substrate of SIRT2ProteinHuman-GEM MAR05339Inferred only
- acetate is a substrate of SIRT3ProteinHuman-GEM MAR05339Inferred only
- acetate is a substrate of SIRT5ProteinHuman-GEM MAR05339Inferred only
- acetate is a substrate of SIRT6ProteinHuman-GEM MAR05339Inferred only
- acetate is a substrate of SIRT7ProteinHuman-GEM MAR05339Inferred only
- acetate is transported by SLC16A1ProteinHuman-GEM MAR04935Inferred only
- acetate is transported by SLC16A1ProteinHuman-GEM MAR06001Inferred only
- acetate is transported by SLC16A1ProteinHuman-GEM MAR06036Inferred only
- acetate is transported by SLC16A1ProteinHuman-GEM MAR06008Inferred only
- acetate is transported by SLC16A1ProteinHuman-GEM MAR06015Inferred only
- acetate is transported by SLC16A1ProteinHuman-GEM MAR06034Inferred only
- acetate is transported by SLC16A1ProteinHuman-GEM MAR06022Inferred only
- acetate is transported by SLC16A1ProteinHuman-GEM MAR06033Inferred only
- acetate is transported by SLC16A1ProteinHuman-GEM MAR06031Inferred only
- acetate is transported by SLC16A1ProteinHuman-GEM MAR06032Inferred only
- acetate is transported by SLC16A1ProteinRhea RHEA:71803Inferred only
- acetate is transported by SLC16A12ProteinHuman-GEM MAR05292Inferred only
- acetate is transported by SLC16A13ProteinHuman-GEM MAR05292Inferred only
- acetate is transported by SLC16A13ProteinHuman-GEM MAR08496Inferred only
- acetate is transported by SLC16A3ProteinHuman-GEM MAR06015Inferred only
- acetate is transported by SLC16A3ProteinHuman-GEM MAR04935Inferred only
- acetate is transported by SLC16A3ProteinHuman-GEM MAR06033Inferred only
- acetate is transported by SLC16A4ProteinHuman-GEM MAR06022Inferred only
- acetate is transported by SLC16A4ProteinHuman-GEM MAR06033Inferred only
- acetate is transported by SLC16A4ProteinHuman-GEM MAR06015Inferred only
- acetate is transported by SLC16A4ProteinHuman-GEM MAR06034Inferred only
- acetate is transported by SLC16A4ProteinHuman-GEM MAR06008Inferred only
- acetate is transported by SLC16A4ProteinHuman-GEM MAR04935Inferred only
- acetate is transported by SLC16A4ProteinHuman-GEM MAR06035Inferred only
- acetate is transported by SLC16A4ProteinHuman-GEM MAR06036Inferred only
- acetate is transported by SLC16A4ProteinHuman-GEM MAR06001Inferred only
- acetate is transported by SLC16A4ProteinHuman-GEM MAR06032Inferred only
- acetate is transported by SLC16A4ProteinHuman-GEM MAR06031Inferred only
- acetate is transported by SLC16A5ProteinHuman-GEM MAR06036Inferred only
- acetate is transported by SLC16A5ProteinHuman-GEM MAR04935Inferred only
- acetate is transported by SLC16A5ProteinHuman-GEM MAR06001Inferred only
- acetate is transported by SLC16A5ProteinHuman-GEM MAR06008Inferred only
- acetate is transported by SLC16A5ProteinHuman-GEM MAR06015Inferred only
- acetate is transported by SLC16A5ProteinHuman-GEM MAR06022Inferred only
- acetate is transported by SLC16A5ProteinHuman-GEM MAR06031Inferred only
- acetate is transported by SLC16A5ProteinHuman-GEM MAR06032Inferred only
- acetate is transported by SLC16A5ProteinHuman-GEM MAR06033Inferred only
- acetate is transported by SLC16A5ProteinHuman-GEM MAR06034Inferred only
- acetate is transported by SLC16A5ProteinHuman-GEM MAR06035Inferred only
- acetate is transported by SLC16A6ProteinHuman-GEM MAR06001Inferred only
- acetate is transported by SLC16A7ProteinHuman-GEM MAR06034Inferred only
- acetate is transported by SLC16A7ProteinHuman-GEM MAR06022Inferred only
- acetate is transported by SLC16A7ProteinHuman-GEM MAR06015Inferred only
- acetate is transported by SLC16A7ProteinHuman-GEM MAR06035Inferred only
- acetate is transported by SLC16A7ProteinHuman-GEM MAR06032Inferred only
- acetate is transported by SLC16A7ProteinHuman-GEM MAR06008Inferred only
- acetate is transported by SLC16A7ProteinHuman-GEM MAR04935Inferred only
- acetate is transported by SLC16A7ProteinHuman-GEM MAR06033Inferred only
- acetate is transported by SLC16A7ProteinHuman-GEM MAR06036Inferred only
- acetate is transported by SLC16A7ProteinHuman-GEM MAR06001Inferred only
- acetate is transported by SLC16A8ProteinHuman-GEM MAR04935Inferred only
- acetate is transported by SLC16A8ProteinHuman-GEM MAR06033Inferred only
- acetate is transported by SLC5A8ProteinRhea RHEA:72947Inferred only
Reactions
246 reactions
Reaction pageReversibleBalancedEC 2.1.1.4cytosol, mitochondrial matrix
Human-GEM MAR00061CC BY 4.0Reference data
acetylcholine+wateracetate+choline+proton
Reaction pageLeft to rightBalancedEC 3.1.1.7, 3.1.1.8cytosol
Human-GEM MAR00641CC BY 4.0Reference data
acetaldehyde+water+NAD(+)acetate+2proton+NADH(2-)
Catalysed by ALDH3B1 or ALDH3A1 or ALDH3B2 or ALDH1A3
Reaction pageLeft to rightBalancedEC 1.2.1.4, 1.2.1.5cytosol
Human-GEM MAR01568CC BY 4.0Reference data
17alpha-hydroxypregnenolone+NADPH(4-)+dioxygenacetate+3beta-hydroxyandrost-5-en-17-one+water+NADP(3-)
Catalysed by CYP17A1
Reaction pageLeft to rightBalancedEC 1.14.99.-cytosol
Human-GEM MAR01959CC BY 4.0Reference data
17alpha-hydroxypregnenolone+NADPH(4-)+dioxygenacetate+3beta-hydroxyandrost-5-en-17-one+water+NADP(3-)
Catalysed by CYP17A1
Reaction pageReversibleBalancedEC 1.14.99.-endoplasmic reticulum
Human-GEM MAR01960CC BY 4.0Reference data
17alpha-hydroxyprogesterone+NADPH(4-)+dioxygenandrost-4-ene-3,17-dione+acetate+water+NADP(3-)
Catalysed by CYP17A1
Reaction pageLeft to rightBalancedEC 1.14.99.-cytosol
Human-GEM MAR01985CC BY 4.0Reference data
17alpha-hydroxyprogesterone+NADPH(4-)+dioxygenandrost-4-ene-3,17-dione+acetate+water+NADP(3-)
Catalysed by CYP17A1
Reaction pageReversibleBalancedEC 1.14.99.-endoplasmic reticulum
Human-GEM MAR01987CC BY 4.0Reference data
cortisol+proton+2NADPH(4-)+dioxygen11beta-hydroxyandrost-4-ene-3,17-dione+acetate+2water+2NADP(3-)
Catalysed by CYP17A1 or CYP11B1 or CYP11B2 or BCO2
Reaction pageLeft to rightBalancedEC 1.14.15.4, 1.14.14.19cytosol
Human-GEM MAR01999CC BY 4.0Reference data
cortisol+proton+2NADPH(4-)+dioxygen11beta-hydroxyandrost-4-ene-3,17-dione+acetate+2water+2NADP(3-)
Catalysed by CYP17A1 or CYP11B1 or CYP11B2
Reaction pageLeft to rightBalancedEC 1.14.15.4, 1.14.99.-mitochondrial matrix
Human-GEM MAR02000CC BY 4.0Reference data
cortisol+proton+2NADPH(4-)+dioxygen11beta-hydroxyandrost-4-ene-3,17-dione+acetate+2water+2NADP(3-)
Catalysed by CYP17A1 or CYP11B1 or CYP11B2
Reaction pageLeft to rightBalancedEC 1.14.15.4, 1.14.99.-endoplasmic reticulum
Human-GEM MAR02001CC BY 4.0Reference data
17alpha-hydroxyprogesterone+NADPH(4-)+dioxygenandrost-4-ene-3,17-dione+acetate+water+NADP(3-)
Catalysed by CYP17A1
Reaction pageLeft to rightBalancedEC 2.4.1.17mitochondrial matrix
Human-GEM MAR02723CC BY 4.0Reference data
17alpha-hydroxypregnenolone+NADPH(4-)+dioxygenacetate+3beta-hydroxyandrost-5-en-17-one+water+NADP(3-)
Catalysed by CYP17A1
Reaction pageLeft to rightBalancedEC 2.4.1.17mitochondrial matrix
Human-GEM MAR02751CC BY 4.0Reference data
Where it reaches
9 systems, 17 regions, 34 tissues, 34 transporter routes — routes, not measurements: transporters known to carry acetate are expressed there, and no source reports it arriving.
Loading the model…
Other names
8 names
Resolves to: acetate
- Also called
- ACETATE IONacetic acid, ion(1-)acetic acid, ion(1−)CH3-COO(-)CH3‒COO−EthanoatethanoateMeCO2 anion