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knowcompoundscalcium carbonatepage read from the graph 2026-11-02

Specimen compoundPlate I

Calcium carbonate

Carbonic acid calcium salt (CaCO3).

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An odorless, tasteless powder or crystal that occurs in nature. It is used therapeutically as a phosphate buffer in hemodialysis patients and as a calcium supplement.”

Rings of hairline contours on a lattice, each the computed X-ray reflection of calcium carbonate's crystal, strong spots ringed many times and weak ones once.
fig. 1calcium carbonate · h0l zone, computed · COD 1010928 (Elliott 1937, C Ca O3, R -3 c RS) · kinematic |F|², Cromer-Mann form factors, B 2 Ų
Formula
CO3.Ca
Molar mass
100.086 g/mol
ChEBI
CHEBI:3311
InChIKey
VTYYLEPIZMXCLO-UHFFFAOYSA-L

Structure

2D depiction

No three-dimensional record for this entry.

Formula
CO3.Ca
Mass
100.086 g/mol
Charge
0
InChIKey
VTYYLEPIZMXCLO-UHFFFAOYSA-L
SMILES
O=C([O-])[O-].[Ca+2]

Identity from ChEBI. Not evidence.

01 · the evidence, ordered

What the evidence says

Strong
0
Moderate
0
Limited
0
Very limited
0
Insufficient
1

How to read these marks

Fig. 2 calcium carbonate CHEBI:33111 endpoint 1 finding on ring 1Sel calcium carbonate · centre · ring 0
×1.00
Labels
CompoundInspector

calcium carbonate

CHEBI:3311

Open the page

Findings drawn, by strength

1finding · 1 endpoint

  • Insufficient1

Most findings

  • ×1

ring 0 · 1 endpoint on ring 1

← → round a ring↑ ↓ out and inEnter selecte one more ringf fit to view+ − zoomEsc clearclick a node to select it

  1. Depletes dopamine
fig. 3 · 1 endpoint · 1 finding · one mark per findingno endpoint contested

02 · findings

What calcium carbonate moved, and by how much

  • Dose studied: as its paper gave it. No dose is advised.
  • Evidence strength: computed from the study. How it is computed

1 row · 1 finding in the record

  1. DopamineMoved: depletesEffect, as reportednot reportedEvidence: InsufficientPaper: PMID:355849402022
    Who
    Mice fed diets containing 0.6% or 1.0% calcium carbonate for eight weeks; basal ganglia (striatum and substantia nigra) tissue
    Dose studied
    0.6% or 1.0% calcium carbonate in diet for eight weeks

    Calcium carbonate supplementation decreased the dopamine content in the basal ganglia, including the striatum and substantia nigra, and the number of tyrosine hydroxylase-positive neurons in the substantia nigra.”

    Quoted verbatim from Calcium carbonate supplementation causes motor dysfunction.animal · not in humans · 8 weeksPermalink

No dose is advised.

03 · interactions

Taken with something else

Documented interactions
None reported

Pairs that share biology

What the reference databases state

Trials · ClinicalTrials.gov
258without posted results · 112 of the 120 read past the reporting window
All 258 registered trials

Registered, and not reported

Source
ClinicalTrials.gov
Intervention
calcium carbonate
Status
Completed, terminated or suspended
Results posted
No

Trials without posted results

258 trials

258 registered trials without posted results · Overdue (FDAAA 801): 112 · Showing 120 of 258

112 past the window8 within it, or no actual date

  • NCT05493761completed2026-07-16a university or hospital
  • NCT07717788completed2026-07-01a university or hospital
  • NCT07668791completed2026-06-10industry
  • NCT07784218completed2026-05-20a university or hospital
  • NCT07743125completed2026-04-14a university or hospital
  • NCT06841536completed2025-12-16a university or hospital
  • NCT07134231completed2025-12-11industry
  • NCT06779929completed2025-12-01a university or hospital
  • NCT06650930completed2025-10-11a university or hospitalpast the reporting window
  • NCT03732768completed2025-09-30industrypast the reporting window
  • NCT05424263completed2025-09-19a university or hospitalpast the reporting window
  • NCT07088718completed2025-07-30a university or hospitalpast the reporting window
Show the remaining 246
Every trial, as data

04 · the record

What was read to make this page

686

papers screened for calcium carbonate

admitted
1
read and discarded
446
not read yet
239

The screening record, every paper and why

Sources cited

1 paper · 1 finding

1Show every paper cited

Other names · 6

CaCO3 · calcium carbonate (1:1) · carbonic acid calcium salt (1:1) · E 170 · Precipitated calcium carbonate

systematic · calcium trioxidocarbonate

Measured, not recorded
202 endpoints
Papers about this node
139 papers

Measured, not recorded

Compound
calcium carbonate
Endpoints measured
202 endpoints
Recorded as a finding
No
Show what was measured
Every row, on one page: 200 rows

The whole record — 202 rows

Papers about it

Papers
139
Harvested for it
53
Read with it as the subject
77
Read with it as a co-exposure
7
Read with it as the comparator
8
In PubMed's chemical list: indexed, not dosed
39
A PubMed MeSH major topic: indexed, not dosed
21
Harvested for it53 papers
12 papers, on their own page

and 41 more.

Read with it as the subject77 papers
12 papers, on their own page

and 65 more.

Read with it as a co-exposure7 papers
7 papers, on their own page
Read with it as the comparator8 papers
8 papers, on their own page
In PubMed's chemical list: indexed, not dosed39 papers
12 papers, on their own page

and 27 more.

A PubMed MeSH major topic: indexed, not dosed21 papers
12 papers, on their own page

and 9 more.