Compound
3-phenylpyruvate
A 2-oxo monocarboxylic acid anion resulting from deprotonation of the carboxy group of keto-phenylpyruvic acid.
Definition from ChEBI (CHEBI:18005), read 2026-09-23. CC BY 4.0.
Structure
Loading the model…
- Class
- Organic compound, anion
- Formula
- C9H7O3
- Mass
- 163.152 g/mol
- Charge
- -1
- InChIKey
- BTNMPGBKDVTSJY-UHFFFAOYSA-M
- SMILES
- O=C([O-])C(=O)Cc1ccccc1
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
12 entities
12 entities reached.
0 reported hops12 assembled from the scaffold
- MPC1ProteinUNIPROT:Q9Y5U8transported byInferred only161 paths145 endpoints
- GOT2ProteinUNIPROT:P00505substrate ofInferred only68 paths34 endpoints
- MIFProteinUNIPROT:P14174substrate ofInferred only64 paths32 endpoints
- MPC2ProteinUNIPROT:O95563transported byInferred only38 paths38 endpoints
- SLC16A1ProteinUNIPROT:P53985transported byInferred only25 paths25 endpoints
- GOT1ProteinUNIPROT:P17174substrate ofInferred only24 paths24 endpoints
- AADATProteinUNIPROT:Q8N5Z0substrate ofInferred only20 paths10 endpoints
- TATProteinUNIPROT:P17735substrate ofInferred only14 paths7 endpoints
- KYAT1ProteinUNIPROT:Q16773substrate ofInferred only9 paths9 endpoints
- HPDProteinUNIPROT:P32754substrate ofInferred only8 paths8 endpoints
- SLC16A3ProteinUNIPROT:O15427transported byInferred only7 paths7 endpoints
- SLC16A7ProteinUNIPROT:O60669transported byInferred only6 paths6 endpoints
What the reference databases state
Chemical structure
- 3-phenylpyruvate has the functional parent pyruvateCompoundChEBI CHEBI:18005Inferred only
Statements
44 statements
44 statements · 2 reference databases · Subject: 3-phenylpyruvate · Sources: Human-GEM, Rhea
- 3-phenylpyruvate is converted to (2-hydroxyphenyl)acetic acidCompoundRhea RHEA:31107Inferred only
- 3-phenylpyruvate is converted to (2-hydroxyphenyl)acetic acidCompoundHuman-GEM MAR06726Inferred only
- (2-hydroxyphenyl)acetic acid is converted to 3-phenylpyruvateCompoundRhea RHEA:31107Inferred only
- 3-phenylpyruvate is converted to (R)-3-phenyllactateCompoundRhea RHEA:38351Inferred only
- (R)-3-phenyllactate is converted to 3-phenylpyruvateCompoundRhea RHEA:38351Inferred only
- (R)-3-phenyllactate is converted to 3-phenylpyruvateCompoundRhea RHEA:82507Inferred only
- 2-phenylacetaldehyde is converted to 3-phenylpyruvateCompoundRhea RHEA:14185Inferred only
- 3-phenylpyruvate is converted to 2-phenylacetaldehydeCompoundRhea RHEA:14185Inferred only
- 3-phenylpyruvate is converted to 3-phenyllactateCompoundRhea RHEA:52692Inferred only
- 3-phenylpyruvate is converted to 3-phenyllactateCompoundHuman-GEM MAR09936Inferred only
- 3-phenylpyruvate is converted to 3-phenyllactateCompoundRhea RHEA:52688Inferred only
- 3-phenyllactate is converted to 3-phenylpyruvateCompoundHuman-GEM MAR09936Inferred only
Show the remaining 32
- 3-phenyllactate is converted to 3-phenylpyruvateCompoundRhea RHEA:52688Inferred only
- 3-phenyllactate is converted to 3-phenylpyruvateCompoundRhea RHEA:52692Inferred only
- D-phenylalanine is converted to 3-phenylpyruvateCompoundRhea RHEA:70963Inferred only
- 3-phenylpyruvate is converted to enol-phenylpyruvateCompoundRhea RHEA:17097Inferred only
- enol-phenylpyruvate is converted to 3-phenylpyruvateCompoundRhea RHEA:17097Inferred only
- 3-phenylpyruvate is converted to L-phenylalanineCompoundRhea RHEA:21408Inferred only
- L-phenylalanine is converted to 3-phenylpyruvateCompoundRhea RHEA:21408Inferred only
- L-phenylalanine is converted to 3-phenylpyruvateCompoundRhea RHEA:25152Inferred only
- 3-phenylpyruvate is converted to L-phenylalanineCompoundHuman-GEM MAR06725Inferred only
- 3-phenylpyruvate is converted to L-phenylalanineCompoundRhea RHEA:25152Inferred only
- L-phenylalanine is converted to 3-phenylpyruvateCompoundHuman-GEM MAR06725Inferred only
- L-phenylalanine is converted to 3-phenylpyruvateCompoundRhea RHEA:61240Inferred only
- 3-phenylpyruvate is converted to L-phenylalanineCompoundHuman-GEM MAR01616Inferred only
- L-phenylalanine is converted to 3-phenylpyruvateCompoundHuman-GEM MAR01616Inferred only
- L-threo-3-phenylserine is converted to 3-phenylpyruvateCompoundRhea RHEA:46328Inferred only
- 3-phenylpyruvate is converted to L-threo-3-phenylserineCompoundRhea RHEA:46328Inferred only
- 3-phenylpyruvate is a substrate of AADATProteinRhea RHEA:69120Inferred only
- 3-phenylpyruvate is a substrate of AADATProteinRhea RHEA:66092Inferred only
- 3-phenylpyruvate is a substrate of GOT1ProteinHuman-GEM MAR06725Inferred only
- 3-phenylpyruvate is a substrate of GOT2ProteinHuman-GEM MAR01616Inferred only
- 3-phenylpyruvate is a substrate of GOT2ProteinHuman-GEM MAR06725Inferred only
- 3-phenylpyruvate is a substrate of HPDProteinHuman-GEM MAR06726Inferred only
- 3-phenylpyruvate is a substrate of KYAT1ProteinRhea RHEA:17593Inferred only
- 3-phenylpyruvate is a substrate of MIFProteinRhea RHEA:17097Inferred only
- 3-phenylpyruvate is a substrate of MIFProteinHuman-GEM MAR06727Inferred only
- 3-phenylpyruvate is a substrate of TATProteinHuman-GEM MAR06725Inferred only
- 3-phenylpyruvate is a substrate of TATProteinHuman-GEM MAR01616Inferred only
- 3-phenylpyruvate is transported by MPC1ProteinHuman-GEM MAR11443Inferred only
- 3-phenylpyruvate is transported by MPC2ProteinHuman-GEM MAR11443Inferred only
- 3-phenylpyruvate is transported by SLC16A1ProteinHuman-GEM MAR11442Inferred only
- 3-phenylpyruvate is transported by SLC16A3ProteinHuman-GEM MAR11442Inferred only
- 3-phenylpyruvate is transported by SLC16A7ProteinHuman-GEM MAR11442Inferred only
Reactions
42 reactions
2-oxoglutarate(2-)+L-phenylalanineL-glutamate(1-)+3-phenylpyruvate
Reaction pageReversibleBalancedEC 2.6.1.58mitochondrial matrix
Human-GEM MAR01616CC BY 4.0Reference data
2-oxoglutarate(2-)+L-phenylalanineL-glutamate(1-)+3-phenylpyruvate
Catalysed by GOT1 or GOT2 or TAT
Reaction pageReversibleBalancedEC 2.6.1.1, 2.6.1.5, 2.6.1.57cytosol
Human-GEM MAR06725CC BY 4.0Reference data
dioxygen+3-phenylpyruvate(2-hydroxyphenyl)acetic acid+carbon dioxide
Catalysed by HPD
Reaction pageLeft to rightBalancedEC 1.13.11.27cytosol
Human-GEM MAR06726CC BY 4.0Reference data
3-phenylpyruvateMAM00647c
Catalysed by MIF
Reaction pageLeft to rightBalancedEC 5.3.2.1cytosol
Human-GEM MAR06727CC BY 4.0Reference data
NAD(+)+3-phenyllactateproton+NADH(2-)+3-phenylpyruvate
Reaction pageReversibleBalancedEC 1.1.1.28cytosol
Human-GEM MAR09936CC BY 4.0Reference data
0.0043(S)-dihydroorotate+0.0014MAM00569c+0.0022(2R)-3-phosphoglycerate+0.0025MAM00916c+0.0002CHEBI:15351+0.0033ADP+0.00462-oxoglutarate(2-)+0.0404L-alanine+0.0002AMP+0.0015L-arginine+0.0012L-asparagine+0.0865L-aspartate+0.0271ATP+0.0034citric acid+0.0234CHEBI:1146900+0.0052CHEBI:17677+0.0005L-cysteine+0.0001MAM01639c+0.0002dCMP+0.0094CHEBI:16108+0.0088MAM01841c+0.0006keto-D-fructose 6-phosphate+0.0028fumaric acid+0.0008CHEBI:29052+0.0002GDP+0.0039D-glucopyranose 6-phosphate+0.3694L-glutamate(1-)+0.0998L-glutamine+0.0215glycine+0.0001GMP+0.0179CHEBI:16856+0.0001glutathione disulfide+0.0039GTP+0.0024CHEBI:15971+0.0002isocitric acid+0.0102L-isoleucine+0.0102L-leucine+0.0029CHEBI:18019+0.0081(S)-malate+0.0037L-methionine+0.0029NAD(+)+0.0004NADH(2-)+0.0002NADP(3-)+0.0004NADPH(4-)+0.0049L-phenylalanine+0.01023-phenylpyruvate+0.0071CHEBI:17203+0.034pyruvate+0.0002CHEBI:17797+0.0282L-seryl residue+0.0388CHEBI:16857+0.001L-tryptophan+0.0054CHEBI:17895+0.0008UDP+0.0088MAM03108c+0.0006UDP-alpha-D-glucuronate+0.052CHEBI:16264+0.0102UTP+0.0088L-valineMAM10015c
Reaction pageLeft to rightBalance undeterminablecytosol
Human-GEM MAR10064CC BY 4.0Reference data
Reaction pageReversibleBalance undeterminableextracellular space
Human-GEM MAR11438CC BY 4.0Reference data
proton+3-phenylpyruvateproton+3-phenylpyruvate
Transported by SLC16A7 or SLC16A3 or SLC16A1
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR11442CC BY 4.0Reference data
proton+3-phenylpyruvateproton+3-phenylpyruvate
Reaction pageReversibleBalancedmitochondrial matrix, cytosol
Human-GEM MAR11443CC BY 4.0Reference data
L-phenylalanine+pyruvate3-phenylpyruvate+L-alanine
Reaction pageDirection not assertedBalanced
Rhea RHEA:13053CC BY 4.0Reference data
3-phenylpyruvate+L-tryptophanindole-3-pyruvate+L-phenylalanine
Reaction pageDirection not assertedBalanced
Rhea RHEA:13741CC BY 4.0Reference data
3-phenylpyruvate+L-aspartateoxaloacetate+L-phenylalanine
Reaction pageDirection not assertedBalanced
Rhea RHEA:14097CC BY 4.0Reference data
Where it reaches
10 systems, 27 regions, 160 tissues, 215 transporter routes — routes, not measurements: transporters known to carry 3-phenylpyruvate are expressed there, and no source reports it arriving.
Loading the model…
Other names
3 names
Resolves to: 3-phenylpyruvate
- Also called
- 3-(4-hydroxyphenyl)pyruvate3-phenyl-2-oxopropanoate
- Systematic name
- 2-oxo-3-phenylpropanoate