Compound

3,5-diiodo-L-tyrosine

An α-amino-acid anion that is the conjugate base of 3,5-diiodo-L-tyrosine.

Definition from ChEBI (CHEBI:57506), read 2026-09-23. CC BY 4.0.

CHEBI:57506ChEBI

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Structure

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A generated conformer of 3,5-diiodo-L-tyrosine — one low-energy arrangement PubChem computed, not a measured structure. Hydrogens are not drawn; the formula counts them.

Class: Organic compound, anion
Formula: C9H8I2NO3
Mass: 431.975 g/mol
Charge: -1
InChIKey: NYPYHUZRZVSYKL-ZETCQYMHSA-M
SMILES: [NH3+][C@@H](Cc1cc(I)c([O-])c(I)c1)C(=O)[O-]
Look it up: ChEBI PubChem By InChIKey

Identity from ChEBI, geometry from PubChem. Not evidence.

What it touches on the way

Mechanistic reach

2 entities

2 entities reached.

0 reported hops2 assembled from the scaffold

What the reference databases state

Statements

4 statements

4 statements · 2 reference databases · Subject: 3,5-diiodo-L-tyrosine · Sources: Human-GEM, Rhea

Order

3,5-diiodo-L-tyrosine is a substrate of IYDProteinRhea RHEA:27457Inferred only
3,5-diiodo-L-tyrosine is a substrate of IYDProteinRhea RHEA:32479Inferred only
3,5-diiodo-L-tyrosine is a substrate of TPOProteinHuman-GEM MAR06795Inferred only
3,5-diiodo-L-tyrosine is a substrate of TPOProteinHuman-GEM MAR06796Inferred only

Reactions

10 reactions

3-iodo-L-tyrosine+diiodine3,5-diiodo-L-tyrosine+proton+iodide
Catalysed by TPO
Reaction pageLeft to rightBalancedEC 1.11.1.8GO:0005829
Human-GEM MAR06794CC BY 4.0Reference data
23,5-diiodo-L-tyrosine+hydrogen peroxide2-aminoacrylic acid+2water+L-thyroxine
Catalysed by TPO
Reaction pageLeft to rightBalancedEC 1.11.1.8GO:0005829
Human-GEM MAR06795CC BY 4.0Reference data
3,5-diiodo-L-tyrosine+3-iodo-L-tyrosine+hydrogen peroxide2-aminoacrylic acid+2water+3,3',5-triiodo-L-thyronine
Catalysed by TPO
Reaction pageLeft to rightBalancedEC 1.11.1.8GO:0005829
Human-GEM MAR06796CC BY 4.0Reference data
3-iodo-L-tyrosine+diiodine3,5-diiodo-L-tyrosine+proton+iodide
Catalysed by TPO
Reaction pageLeft to rightBalancedEC 1.11.1.8GO:0005829
Human-GEM MAR08543CC BY 4.0Reference data
3,5-diiodo-L-tyrosine+sodium(1+)3,5-diiodo-L-tyrosine+sodium(1+)
Reaction pageReversibleBalancedGO:0005829, GO:0005615
Human-GEM MAR11892CC BY 4.0Reference data
3,5-diiodo-L-tyrosine
Reaction pageReversibleBalance undeterminableGO:0005615
Human-GEM MAR11893CC BY 4.0Reference data
3,5-diiodo-L-tyrosine+2-oxoglutarate(2-)CHEBI:58023+L-glutamate(1-)
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:19781CC BY 4.0Reference data
3-iodo-L-tyrosine+iodide+NADP(3-)3,5-diiodo-L-tyrosine+NADPH(4-)+hydron
Catalysed by IYD
Reaction pageRight to leftBalance undeterminable
Rhea RHEA:27457CC BY 4.0Reference data
2iodide+L-tyrosine+2NADP(3-)3,5-diiodo-L-tyrosine+2NADPH(4-)+hydron
Catalysed by IYD
Reaction pageRight to leftBalance undeterminable
Rhea RHEA:32479CC BY 4.0Reference data
3,5-diiodo-L-tyrosine3,5-diiodo-L-tyrosine
Transported by SLC16A2 or SLC7A5 or SLC7A8
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:82879CC BY 4.0Reference data

Other names

2 names

Resolves to: 3,5-diiodo-L-tyrosine

Also called: (2S)-2-ammonio-3-(3,5-diiodo-4-oxidophenyl)propanoate
Systematic name: (2S)-2-azaniumyl-3-(3,5-diiodo-4-oxidophenyl)propanoate