Compound
dehydroepiandrosterone 3-sulfate
The conjugate base of 3β-hydroxyandrost-5-en-17-one 3-sulfate arising from deprotonation of the sulfate OH group; major species at pH 7.3.
Definition from ChEBI (CHEBI:57905), read 2026-09-23. CC BY 4.0.
Structure
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- Class
- Organic compound, anion
- Formula
- C19H27O5S
- Mass
- 367.487 g/mol
- Charge
- -1
- InChIKey
- CZWCKYRVOZZJNM-USOAJAOKSA-M
- SMILES
- [H][C@@]12CC=C3C[C@@H](OS(=O)(=O)[O-])CC[C@]3(C)[C@@]1([H])CC[C@]1(C)C(=O)CC[C@@]21[H]
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
16 entities
16 entities reached.
0 reported hops16 assembled from the scaffold
- STSProteinUNIPROT:P08842substrate ofInferred only42 paths14 endpoints
- ABCC3ProteinUNIPROT:O15438transported byInferred only33 paths30 endpoints
- SLCO1B1ProteinUNIPROT:Q9Y6L6transported byInferred only15 paths2 endpoints
- ABCG2ProteinUNIPROT:Q9UNQ0transported byInferred only14 paths14 endpoints
- CYP3A7ProteinUNIPROT:P24462metabolized byInferred only14 paths14 endpoints
- SLC10A6ProteinUNIPROT:Q3KNW5transported byInferred only11 paths11 endpoints
- ABCC4ProteinUNIPROT:O15439transported byInferred only10 paths10 endpoints
- SLC51BProteinUNIPROT:Q86UW2transported byInferred only9 paths9 endpoints
- SLCO1B3ProteinUNIPROT:Q9NPD5transported byInferred only6 paths2 endpoints
- SLCO2B1ProteinUNIPROT:O94956transported byInferred only6 paths2 endpoints
- SLC51AProteinUNIPROT:Q86UW1transported byInferred only5 paths5 endpoints
- SLC22A11ProteinUNIPROT:Q9NSA0transported byInferred only4 paths2 endpoints
Show the remaining 4
What the reference databases state
Statements
39 statements
39 statements · 2 reference databases · Subject: dehydroepiandrosterone 3-sulfate · Sources: Human-GEM, Rhea
- 3beta-hydroxyandrost-5-en-17-one is converted to dehydroepiandrosterone 3-sulfateCompoundHuman-GEM MAR01969Inferred only
- 3beta-hydroxyandrost-5-en-17-one is converted to dehydroepiandrosterone 3-sulfateCompoundRhea RHEA:51216Inferred only
- dehydroepiandrosterone 3-sulfate is metabolised by CYP3A7ProteinRhea RHEA:47224Inferred only
- dehydroepiandrosterone 3-sulfate is a substrate of STSProteinHuman-GEM MAR00794Inferred only
- dehydroepiandrosterone 3-sulfate is a substrate of STSProteinHuman-GEM MAR07952Inferred only
- dehydroepiandrosterone 3-sulfate is a substrate of STSProteinRhea RHEA:19873Inferred only
- dehydroepiandrosterone 3-sulfate is transported by ABCC11ProteinRhea RHEA:61364Inferred only
- dehydroepiandrosterone 3-sulfate is transported by ABCC11ProteinHuman-GEM MAR09877Inferred only
- dehydroepiandrosterone 3-sulfate is transported by ABCC11ProteinHuman-GEM MAR06249Inferred only
- dehydroepiandrosterone 3-sulfate is transported by ABCC3ProteinRhea RHEA:61364Inferred only
- dehydroepiandrosterone 3-sulfate is transported by ABCC4ProteinRhea RHEA:61364Inferred only
- dehydroepiandrosterone 3-sulfate is transported by ABCG2ProteinRhea RHEA:61364Inferred only
Show the remaining 27
- dehydroepiandrosterone 3-sulfate is transported by SLC10A6ProteinRhea RHEA:71091Inferred only
- dehydroepiandrosterone 3-sulfate is transported by SLC22A11ProteinHuman-GEM MAR09623Inferred only
- dehydroepiandrosterone 3-sulfate is transported by SLC22A11ProteinRhea RHEA:71839Inferred only
- dehydroepiandrosterone 3-sulfate is transported by SLC22A24ProteinRhea RHEA:72355Inferred only
- dehydroepiandrosterone 3-sulfate is transported by SLC22A7ProteinHuman-GEM MAR09623Inferred only
- dehydroepiandrosterone 3-sulfate is transported by SLC22A8ProteinRhea RHEA:72543Inferred only
- dehydroepiandrosterone 3-sulfate is transported by SLC22A8ProteinRhea RHEA:72355Inferred only
- dehydroepiandrosterone 3-sulfate is transported by SLC22A9ProteinRhea RHEA:72571Inferred only
- dehydroepiandrosterone 3-sulfate is transported by SLC22A9ProteinRhea RHEA:72567Inferred only
- dehydroepiandrosterone 3-sulfate is transported by SLC22A9ProteinRhea RHEA:72563Inferred only
- dehydroepiandrosterone 3-sulfate is transported by SLC46A3ProteinRhea RHEA:75487Inferred only
- dehydroepiandrosterone 3-sulfate is transported by SLC51AProteinRhea RHEA:71839Inferred only
- dehydroepiandrosterone 3-sulfate is transported by SLC51BProteinRhea RHEA:71839Inferred only
- dehydroepiandrosterone 3-sulfate is transported by SLCO1A2ProteinHuman-GEM MAR08847Inferred only
- dehydroepiandrosterone 3-sulfate is transported by SLCO1A2ProteinRhea RHEA:71839Inferred only
- dehydroepiandrosterone 3-sulfate is transported by SLCO1B1ProteinHuman-GEM MAR08847Inferred only
- dehydroepiandrosterone 3-sulfate is transported by SLCO1B1ProteinHuman-GEM MAR06134Inferred only
- dehydroepiandrosterone 3-sulfate is transported by SLCO1B1ProteinHuman-GEM MAR06133Inferred only
- dehydroepiandrosterone 3-sulfate is transported by SLCO1B1ProteinHuman-GEM MAR06135Inferred only
- dehydroepiandrosterone 3-sulfate is transported by SLCO1B1ProteinRhea RHEA:71839Inferred only
- dehydroepiandrosterone 3-sulfate is transported by SLCO1B3ProteinRhea RHEA:71839Inferred only
- dehydroepiandrosterone 3-sulfate is transported by SLCO1B3ProteinHuman-GEM MAR08847Inferred only
- dehydroepiandrosterone 3-sulfate is transported by SLCO1B3-SLCO1B7ProteinRhea RHEA:71839Inferred only
- dehydroepiandrosterone 3-sulfate is transported by SLCO2B1ProteinHuman-GEM MAR08847Inferred only
- dehydroepiandrosterone 3-sulfate is transported by SLCO2B1ProteinHuman-GEM MAR06249Inferred only
- dehydroepiandrosterone 3-sulfate is transported by SLCO2B1ProteinRhea RHEA:71839Inferred only
- dehydroepiandrosterone 3-sulfate is transported by SLCO3A1ProteinRhea RHEA:71839Inferred only
Reactions
26 reactions
dehydroepiandrosterone 3-sulfate+water3beta-hydroxyandrost-5-en-17-one+proton+sulfate
Catalysed by STS
Reaction pageLeft to rightBalancedEC 3.1.6.2cytosol
Human-GEM MAR00794CC BY 4.0Reference data
3beta-hydroxyandrost-5-en-17-one+3'-phospho-5'-adenylyl sulfatedehydroepiandrosterone 3-sulfate+proton+adenosine 3',5'-bismonophosphate
Catalysed by SULT1E1
Reaction pageLeft to rightBalancedEC 2.8.2.4cytosol
Human-GEM MAR01969CC BY 4.0Reference data
dehydroepiandrosterone 3-sulfate+MAM01980c+hydrogencarbonatedehydroepiandrosterone 3-sulfate+MAM01980e+hydrogencarbonate
Transported by SLCO1B1
Reaction pageReversibleBalance undeterminableextracellular space, cytosol
Human-GEM MAR06133CC BY 4.0Reference data
dehydroepiandrosterone 3-sulfate+hydrogencarbonate+2,4-dinitrophenyl-S-glutathionedehydroepiandrosterone 3-sulfate+hydrogencarbonate+2,4-dinitrophenyl-S-glutathione
Transported by SLCO1B1
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR06134CC BY 4.0Reference data
dehydroepiandrosterone 3-sulfate+hydrogencarbonate+MAM02901cdehydroepiandrosterone 3-sulfate+hydrogencarbonate+MAM02901e
Transported by SLCO1B1
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR06135CC BY 4.0Reference data
dehydroepiandrosterone 3-sulfatedehydroepiandrosterone 3-sulfate
Transported by ABCC11 or SLCO2B1
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR06249CC BY 4.0Reference data
dehydroepiandrosterone 3-sulfatedehydroepiandrosterone 3-sulfate
Reaction pageReversibleBalancedcytosol, endoplasmic reticulum
Human-GEM MAR07951CC BY 4.0Reference data
dehydroepiandrosterone 3-sulfate+water3beta-hydroxyandrost-5-en-17-one+proton+sulfate
Catalysed by STS
Reaction pageLeft to rightBalancedEC 3.1.6.2endoplasmic reticulum
Human-GEM MAR07952CC BY 4.0Reference data
dehydroepiandrosterone 3-sulfate+hydrogencarbonatedehydroepiandrosterone 3-sulfate+hydrogencarbonate
Transported by SLCO1A2 or SLCO1B3 or SLCO1B1 or SLCO2B1
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR08847CC BY 4.0Reference data
dehydroepiandrosterone 3-sulfate
Reaction pageReversibleBalance undeterminableextracellular space
Human-GEM MAR09302CC BY 4.0Reference data
2-oxoglutarate(2-)+dehydroepiandrosterone 3-sulfate2-oxoglutarate(2-)+dehydroepiandrosterone 3-sulfate
Transported by SLC22A7 or SLC22A11
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR09623CC BY 4.0Reference data
ATP+dehydroepiandrosterone 3-sulfate+waterADP+dehydroepiandrosterone 3-sulfate+proton+phosphate(3-)
Transported by ABCC11
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR09877CC BY 4.0Reference data
Where it reaches
10 systems, 20 regions, 50 tissues, 92 transporter routes — routes, not measurements: transporters known to carry dehydroepiandrosterone 3-sulfate are expressed there, and no source reports it arriving.
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Other names
7 names
Resolves to: dehydroepiandrosterone 3-sulfate
- Also called
- 3beta-hydroxyandrost-5-en-17-one 3-sulfate3beta-hydroxyandrost-5-en-17-one 3-sulfate anion3beta-hydroxyandrost-5-en-17-one 3-sulfate(1-)3β-hydroxyandrost-5-en-17-one 3-sulfate anion3β-hydroxyandrost-5-en-17-one 3-sulfate(1−)
- Systematic name
- 17-oxoandrost-5-en-3beta-yl sulfate17-oxoandrost-5-en-3β-yl sulfate