Compound

losartan

An antagonist of angiotensin type 1 receptor with antihypertensive activity due to the reduced pressor effect of angiotensin II.

Definition from MeSH (D019808), National Library of Medicine, read 2026-09-23. NLM revises MeSH; this copy may not reflect its current record.

CHEBI:149504ChEBI

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Structure

2D depiction · 3D model shown

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A generated conformer of losartan — one low-energy arrangement PubChem computed, not a measured structure. Hydrogens are not drawn; the formula counts them.

Class: Organic compound, anion
Formula: C22H22ClN6O
Mass: 421.912 g/mol
Charge: -1
InChIKey: MDMTUGIZSFHDIC-UHFFFAOYSA-N
SMILES: CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2-c2nnn[n-]2)cc1
Look it up: ChEBI PubChem By InChIKey

Identity from ChEBI, geometry from PubChem. Not evidence.

What it touches on the way

Mechanistic reach

4 entities

4 entities reached.

0 reported hops4 assembled from the scaffold

What the reference databases state

Regulatory determinations

LiverTox likelihood score CLiverTox
LiverTox Likelihood Score C — probably linked to idiosyncratic liver injury, reported uncommonly. Chapter: "Losartan". Source: LiverTox Master List (NBK571102).
The document·Public Domain (NLM/NIH)·Transcribed, not assessed

Statements

5 statements

5 statements · 1 reference database · Subject: losartan · Sources: Rhea

Order

losartan is converted to losartan-2-N-beta-D-glucuronideCompoundRhea RHEA:63720Inferred only
losartan is metabolised by UGT1A1ProteinRhea RHEA:63720Inferred only
losartan is metabolised by UGT1A10ProteinRhea RHEA:63720Inferred only
losartan is metabolised by UGT1A3ProteinRhea RHEA:63720Inferred only
losartan is metabolised by UGT2B7ProteinRhea RHEA:63720Inferred only

Reactions

2 reactions

losartan+UDP-alpha-D-glucuronateCHEBI:149506+UDP
Reaction pageDirection not assertedBalanced
Rhea RHEA:63716CC BY 4.0Reference data
losartan+UDP-alpha-D-glucuronatelosartan-2-N-beta-D-glucuronide+UDP
Catalysed by UGT2B7 or UGT1A1 or UGT1A3 or UGT1A10
Reaction pageLeft to rightBalanced
Rhea RHEA:63720CC BY 4.0Reference data

Other names

1 name

Resolves to: losartan

Systematic name: 5-(4'-{[2-butyl-4-chloro-5-(hydroxymethyl)-1H-imidazol-1-yl]methyl}[biphenyl]-2-yl)tetrazol-1-ide