Compound
creatinine
A waste product produced by dietary protein digestion and breakdown product of creatine phosphate in muscle. Creatinine levels in the blood can be an indicator of kidney function.
Structure
A lactam obtained by formal cyclocondensation of creatine. It is a metabolite of creatine.
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- Class
- Organic compound
- Formula
- C4H7N3O
- Mass
- 113.12 g/mol
- Charge
- 0
- InChIKey
- DDRJAANPRJIHGJ-UHFFFAOYSA-N
- SMILES
- CN1CC(=O)NC1=N
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
5 entities
5 entities reached.
0 reported hops5 assembled from the scaffold
- SLC47A1ProteinUNIPROT:Q96FL8transported byInferred only34 paths16 endpoints
- creatineCompoundCHEBI:16919converted toInferred only33 paths19 endpoints
- SLC22A2ProteinUNIPROT:O15244transported byInferred only10 paths5 endpoints
- SLC47A2ProteinUNIPROT:Q86VL8transported byInferred only2 paths1 endpoint
- SLC22A7ProteinUNIPROT:Q9Y694transported byInferred only2 paths2 endpoints
What the reference databases state
Chemical structure
- creatinine has the functional parent creatineCompoundChEBI CHEBI:16737Inferred only
Statements
10 statements
10 statements · 2 reference databases · Subject: creatinine · Sources: Human-GEM, Rhea
- creatine is converted to creatinineCompoundRhea RHEA:14533Inferred only
- creatinine is converted to creatineCompoundRhea RHEA:14533Inferred only
- N-phosphocreatine is converted to creatinineCompoundHuman-GEM MAR08431Inferred only
- creatinine is transported by SLC22A2ProteinRhea RHEA:74539Inferred only
- creatinine is transported by SLC22A2ProteinHuman-GEM MAR09195Inferred only
- creatinine is transported by SLC22A7ProteinRhea RHEA:74539Inferred only
- creatinine is transported by SLC47A1ProteinRhea RHEA:72183Inferred only
- creatinine is transported by SLC47A1ProteinHuman-GEM MAR09619Inferred only
- creatinine is transported by SLC47A2ProteinHuman-GEM MAR09619Inferred only
- creatinine is transported by SLC47A2ProteinRhea RHEA:72183Inferred only
Reactions
8 reactions
N-phosphocreatinecreatinine+phosphate(3-)
Reaction pageLeft to rightBalancedcytosol
Human-GEM MAR08431CC BY 4.0Reference data
Transported by SLC22A2
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR09195CC BY 4.0Reference data
Reaction pageReversibleBalance undeterminableextracellular space
Human-GEM MAR09460CC BY 4.0Reference data
creatinine+protoncreatinine+proton
Transported by SLC47A1 or SLC47A2
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR09619CC BY 4.0Reference data
creatinine+water+hydronCHEBI:16354+ammonium
Reaction pageDirection not assertedBalanced
Rhea RHEA:12681CC BY 4.0Reference data
Reaction pageDirection not assertedBalanced
Rhea RHEA:14533CC BY 4.0Reference data
creatinine+hydroncreatinine+hydron
Transported by SLC47A2 or SLC47A1
Reaction pageDirection not assertedBalanced
Rhea RHEA:72183CC BY 4.0Reference data
Transported by SLC22A2 or SLC22A7
Reaction pageDirection not assertedBalanced
Rhea RHEA:74539CC BY 4.0Reference data
Where it reaches
5 systems, 8 regions, 17 tissues, 19 transporter routes — routes, not measurements: transporters known to carry creatinine are expressed there, and no source reports it arriving.
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Other names
6 names
Resolves to: creatinine
- Also called
- 1-Methylglycocyamidine1-Methylhydantoin-2-imide2-Amino-1-methylimidazolin-4-one2-amino-1,5-dihydro-1-methyl-4H-Imidazol-4-oneCreatine anhydride
- Systematic name
- 2-imino-1-methylimidazolidin-4-one