Endpoint
Systemic vascular resistance
The force that opposes the flow of blood through a vascular bed. It is equal to the difference in blood pressure across the vascular bed divided by the cardiac output.
CAT:outcome/systemic-vascular-resistancereported in dyn.s/cm^52 findings from 2 compounds
What moved it
How to read these marks2 findings · 2 compounds · 2 null · by evidence strength
| Compound | Direction | Findings | Strongest evidence |
|---|---|---|---|
| sodium nitrite | no effect | 1 | Evidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers. |
| methylene blue | no effect | 1 | Evidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence. |
Every finding here is a null result.
Measured, no effect detected
2 findings
sodium nitrite — no detected effect on
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“Nitrite had no effect on resting pulmonary or systemic vascular resistance, VO2, CI, CaO2 – CvO2, or SVI compared to placebo.”
Quoted verbatim from Inhaled Sodium Nitrite Improves Rest and Exercise Hemodynamics in Heart Failure With Preserved Ejection Fraction.. - Study
- RCT
- Dose
- 90 mg nebulized sodium nitrite, single dose
- Population
- Adults with heart failure with preserved ejection fraction undergoing cardiac catheterization, measured at rest after a single 5-minute nebulization of inhaled sodium nitrite versus inhaled saline placebo
Inhaled Sodium Nitrite Improves Rest and Exercise Hemodynamics in Heart Failure With Preserved Ejection Fraction.2016PMID:27458234Permalink
methylene blue — no detected effect on
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.FindingNull result“Pooled analysis revealed that mean arterial pressure, systemic vascular resistance, heart rate, and hospital stay were not statistically significant in methylene blue administration compared to control.”
Quoted verbatim from Methylene blue for vasoplegic syndrome in cardiopulmonary bypass surgery: A systematic review and meta-analysis.. - Study
- meta-analysis
- Population
- adult patients with vasoplegic syndrome, methylene blue as adjunct treatment compared to control treatments
Methylene blue for vasoplegic syndrome in cardiopulmonary bypass surgery: A systematic review and meta-analysis.2021PMID:33653154Permalink
How it is measured
Systemic vascular resistance calculated from the standard haemodynamic formula using invasively or non-invasively measured perfusion pressures and cardiac output, with the cardiac output method (thermodilution, pulse contour analysis, echocardiography) recorded with each finding.
Measured, not recorded
- Subject
- systemic vascular resistance
- Measurements
- 3 measurements
- Recorded as a finding
- No
Show what was measured
systemic vascular resistance
no effect
Pooled analysis revealed that mean arterial pressure, systemic vascular resistance, heart rate, and hospital stay were not statistically significant in methylene blue administration compared to control
PMID:33653154 · one of two readings recorded this
systemic vascular resistance
increases, p = 0.02
systemic vascular resistance (MD, 94.5 dyn/s/cm5 [95% CI 17.73-171.15] p = 0.02)
PMID:37880041 · one of two readings recorded this
systemic vascular resistance
no effect
No differences were observed in systemic vascular resistance or mortality between groups
PMID:39438181 · one of two readings recorded this
Sources cited
2 papers
- Subject
- systemic vascular resistance
- Findings
- 2
- Papers
- 2