Compound

1,2-dihexadecanoyl-sn-glycero-3-phosphocholine

Synthetic phospholipid used in liposomes and lipid bilayers to study biological membranes. It is also a major constituent of pulmonary surfactants.

Definition from MeSH (D015060), National Library of Medicine, read 2026-09-23. NLM revises MeSH; this copy may not reflect its current record.

CHEBI:72999ChEBI

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Structure

2D depiction

No three-dimensional record for this entry.

Class: Organic compound
Formula: C40H80NO8P
Mass: 734.053 g/mol
Charge: 0
InChIKey: KILNVBDSWZSGLL-KXQOOQHDSA-N
SMILES: CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)([O-])OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC
Look it up: ChEBI By InChIKey

Identity from ChEBI. Not evidence.

What it touches on the way

Mechanistic reach

27 entities

27 entities reached.

0 reported hops27 assembled from the scaffold

Show the remaining 15

What the reference databases state

Chemical structure

1,2-dihexadecanoyl-sn-glycero-3-phosphocholine has the functional parent hexadecanoic acidCompoundChEBI CHEBI:72999Inferred only

Statements

43 statements

43 statements · 1 reference database · Subject: 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine · Sources: Rhea

Order

1,2-dihexadecanoyl-sn-glycero-3-phosphocholine is a substrate of LIPCProteinRhea RHEA:41384Inferred only
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine is a substrate of LIPGProteinRhea RHEA:41384Inferred only
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine is a substrate of LPLProteinRhea RHEA:41384Inferred only
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine is a substrate of LRATProteinRhea RHEA:56244Inferred only
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine is a substrate of LRATProteinRhea RHEA:43904Inferred only
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine is a substrate of PLA2G10ProteinRhea RHEA:41223Inferred only
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine is a substrate of PLA2G15ProteinRhea RHEA:41223Inferred only
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine is a substrate of PLA2G15ProteinRhea RHEA:40487Inferred only
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine is a substrate of PLA2G1BProteinRhea RHEA:41223Inferred only
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine is a substrate of PLA2G2AProteinRhea RHEA:41223Inferred only
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine is a substrate of PLA2G2DProteinRhea RHEA:41223Inferred only
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine is a substrate of PLA2G2EProteinRhea RHEA:41223Inferred only

Show the remaining 31

1,2-dihexadecanoyl-sn-glycero-3-phosphocholine is a substrate of PLA2G4CProteinRhea RHEA:41223Inferred only
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine is a substrate of PLA2G4EProteinRhea RHEA:45172Inferred only
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine is a substrate of PLA2G4EProteinRhea RHEA:63592Inferred only
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine is a substrate of PLA2G6ProteinRhea RHEA:41223Inferred only
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine is a substrate of PLAAT1ProteinRhea RHEA:41360Inferred only
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine is a substrate of PLAAT1ProteinRhea RHEA:41223Inferred only
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine is a substrate of PLAAT1ProteinRhea RHEA:40487Inferred only
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine is a substrate of PLAAT1ProteinRhea RHEA:41364Inferred only
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine is a substrate of PLAAT2ProteinRhea RHEA:45176Inferred only
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine is a substrate of PLAAT2ProteinRhea RHEA:40487Inferred only
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine is a substrate of PLAAT2ProteinRhea RHEA:54488Inferred only
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine is a substrate of PLAAT2ProteinRhea RHEA:41223Inferred only
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine is a substrate of PLAAT2ProteinRhea RHEA:45172Inferred only
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine is a substrate of PLAAT3ProteinRhea RHEA:41360Inferred only
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine is a substrate of PLAAT3ProteinRhea RHEA:40487Inferred only
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine is a substrate of PLAAT3ProteinRhea RHEA:41223Inferred only
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine is a substrate of PLAAT3ProteinRhea RHEA:41384Inferred only
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine is a substrate of PLAAT4ProteinRhea RHEA:40487Inferred only
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine is a substrate of PLAAT4ProteinRhea RHEA:41223Inferred only
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine is a substrate of PLAAT5ProteinRhea RHEA:45172Inferred only
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine is a substrate of PLAAT5ProteinRhea RHEA:45176Inferred only
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine is a substrate of PLB1ProteinRhea RHEA:41223Inferred only
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine is a substrate of PLB1ProteinRhea RHEA:40975Inferred only
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine is a substrate of PLD1ProteinRhea RHEA:44872Inferred only
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine is a substrate of PLD2ProteinRhea RHEA:44872Inferred only
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine is a substrate of PRDX6ProteinRhea RHEA:41223Inferred only
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine is a substrate of SGMS2ProteinRhea RHEA:43324Inferred only
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine is a substrate of SMPD1ProteinRhea RHEA:45304Inferred only
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine is a substrate of TAFAZZINProteinRhea RHEA:68988Inferred only
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine is transported by ABCA3ProteinRhea RHEA:66340Inferred only
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine is transported by PLTPProteinRhea RHEA:46488Inferred only

Reactions

24 reactions

1-hexadecanoyl-sn-glycero-3-phosphocholine+hexadecanoyl-CoA1,2-dihexadecanoyl-sn-glycero-3-phosphocholine+coenzyme A(4-)
Catalysed by PRDX6 or LPCAT3 or LPCAT1
Reaction pageLeft to rightBalanced
Rhea RHEA:35983CC BY 4.0Reference data
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine+water2-hexadecanoyl-sn-glycero-3-phosphocholine+hexadecanoate+hydron
Catalysed by PLAAT3 or PLA2G15 or PLAAT1 or PLAAT2 or PLAAT4
Reaction pageLeft to rightBalanced
Rhea RHEA:40487CC BY 4.0Reference data
21-hexadecanoyl-sn-glycero-3-phosphocholine1,2-dihexadecanoyl-sn-glycero-3-phosphocholine+sn-glycerol 3-phosphocholine
Catalysed by ASPG or PLA2G4C
Reaction pageLeft to rightBalanced
Rhea RHEA:40879CC BY 4.0Reference data
22-hexadecanoyl-sn-glycero-3-phosphocholine1,2-dihexadecanoyl-sn-glycero-3-phosphocholine+sn-glycerol 3-phosphocholine
Catalysed by ASPG
Reaction pageLeft to rightBalanced
Rhea RHEA:40907CC BY 4.0Reference data
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine+2watersn-glycerol 3-phosphocholine+2hexadecanoate+2hydron
Catalysed by PLB1
Reaction pageLeft to rightBalanced
Rhea RHEA:40975CC BY 4.0Reference data
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine+water1-hexadecanoyl-sn-glycero-3-phosphocholine+hexadecanoate+hydron
Catalysed by PLA2G10 or PLA2G6 or PLA2G1B or PLA2G2A or PRDX6 or PLAAT3 or PLB1 or PLA2G15 or PLAAT1 or PLAAT2 or PLA2G2E or PLAAT4 and 2 more alternatives
Reaction pageLeft to rightBalanced
Rhea RHEA:41223CC BY 4.0Reference data
1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine+1,2-dihexadecanoyl-sn-glycero-3-phosphocholinehexadecanoyl-sn-glycero-3-phosphocholine+N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine+hydron
Catalysed by PLAAT3 or PLAAT1
Reaction pageLeft to rightBalanced
Rhea RHEA:41360CC BY 4.0Reference data
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine+a 2-acyl-sn-glycero-3-phosphocholinea 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine+2-hexadecanoyl-sn-glycero-3-phosphocholine
Catalysed by PLAAT1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:41364CC BY 4.0Reference data
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine+waterhexadecanoyl-sn-glycero-3-phosphocholine+hexadecanoate+hydron
Catalysed by LPL or LIPC or PLAAT3 or LIPG
Reaction pageLeft to rightBalanced
Rhea RHEA:41384CC BY 4.0Reference data
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine+an N-acylsphing-4-enine1,2-dihexadecanoyl-sn-glycerol+a sphingomyelin
Catalysed by SGMS2
Reaction pageReversibleBalance undeterminable
Rhea RHEA:43324CC BY 4.0Reference data
all-trans-retinol+1,2-dihexadecanoyl-sn-glycero-3-phosphocholineall-trans-retinyl hexadecanoate+2-hexadecanoyl-sn-glycero-3-phosphocholine
Catalysed by LRAT
Reaction pageLeft to rightBalanced
Rhea RHEA:43904CC BY 4.0Reference data
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine+water1,2-dihexadecanoyl-sn-glycero-3-phosphate+choline+hydron
Catalysed by PLD2 or PLD1
Reaction pageLeft to rightBalanced
Rhea RHEA:44872CC BY 4.0Reference data

Show the remaining 12

Where it reaches

10 systems, 26 regions, 74 tissues, 78 transporter routes — routes, not measurements: transporters known to carry 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine are expressed there, and no source reports it arriving.

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Nervous

Endocrine

Respiratory

Cardiovascular

Digestive

Urinary

Reproductive

Blood and immune

Musculoskeletal

Skin and adipose

Other names

27 names

Resolves to: 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine

Also called: 1-16:0-2-16:0-phosphatidylcholine1,2-Bis(hexadecanoyl)-sn-glycero-3-phosphocholine1,2-Dipalmitoyl-3-sn-phosphatidylcholine1,2-Dipalmitoyl-L-lecithin1,2-Dipalmitoyl-sn-glycero-3-phosphatidylcholine1,2-dipalmitoyl-sn-glycero-3-phosphocholine1,2-dipalmitoylphosphatidylcholine16:0-16:0-PCcolfosceril palmitateDipalmitoyl phosphatidylcholinedipalmitoyl-GPCDipalmitoyl-phosphatidylcholinedipalmitoylphosphatidylcholineDPPCGPC(16:0/16:0)GPCho 16:0/16:0GPCho(16:0/16:0)PC 16:0/16:0PC 32:0PC(16:0_16:0)PC(16:0/16:0)PC(32:0)phosphatidylcholine 16:0/16:0Phosphatidylcholine(16:0/16:0)Phosphatidylcholine(32:0)
Systematic name: (2R)-2,3-bis(hexadecanoyloxy)propyl 2-(trimethylammonio)ethyl phosphate(2R)-2,3-bis(hexadecanoyloxy)propyl 2-(trimethylazaniumyl)ethyl phosphate