C-reactive protein concentration

Method

Serum or plasma C-reactive protein (CRP), including high-sensitivity CRP (hs-CRP), by clinical immunoassay. Assay and sensitivity recorded on the edge.

The method is part of the endpoint identity. Studies measuring the same quantity by a different method are held as separate endpoints.

Notes

Standard CRP and hs-CRP are the same analyte at different detection floors, so they share a node with the assay on the edge. That is a different situation from Jaffe versus enzymatic creatinine, where the methods disagree about the value itself.

Findings

8 findings from 8 compounds, strongest first.

• coenzyme Q10 — no detected effect on

  AWell establishedGrade A, Well established. Replicated human trial evidence, consistent direction.FindingNull result

  “The differences in the CRP and ESR levels were not significant between CoQ10 and placebo groups (P = 0.550 and P = 0.306, respectively) (Table  2).”

  Study

  RCT

  Participants

  52

  Duration

  10 days

  Dose

  100 mg three times a day after meals, total 300 mg/day

  Population

  Adults aged 18-65 with 20-60% total body surface area burns admitted to a burn ICU in Isfahan, Iran, all receiving routine burn care and the unit's standard vitamin, selenium, zinc and B-complex supplementation in both arms; primary outcome.

  Coenzyme Q10 supplementation in burn patients: a double-blind placebo-controlled randomized clinical trial.2024PMID:38431600

• resveratrol — no detected effect on

  AWell establishedGrade A, Well established. Replicated human trial evidence, consistent direction.FindingNull result

  “The pooled effect estimate revealed no effect of resveratrol on the CRP (MD = 0.00; 95% CI [-1.31, 1.31], P = 1.00).”

  Study

  meta-analysis

  Participants

  148

  Dose

  800, 1000 or 1500 mg/day oral resveratrol

  Population

  Women with polycystic ovary syndrome; 3 pooled RCTs, resveratrol vs placebo

  Effect 0 mean difference, 95% CI -1.31 to 1.31

  Efficacy of resveratrol in women with polycystic ovary syndrome: a systematic review and meta-analysis of randomized clinical trials.2023PMID:37333786

• magnesium(2+) — decreases

  BLikelyGrade B, Likely. Human evidence, limited replication or design limits.Finding

  “In meta-analysis, Mg supplementation significantly decreased serum C reactive protein (CRP) and increased nitric oxide (NO) levels.”

  Study

  meta-analysis

  Population

  Adults in RCTs of oral Mg supplementation vs placebo (mean age 46 y, 62.5% female)

  Effect of Magnesium Supplementation on Inflammatory Parameters: A Meta-Analysis of Randomized Controlled Trials.2022PMID:35277037

• L-glutamine — decreases

  BLikelyGrade B, Likely. Human evidence, limited replication or design limits.Finding

  “Meta-analysis showed that glutamine supplementation significantly decreased significantly serum levels of FPG [SMD: - 0.73, 95% CI - 1.35, - 0.11, I2: 84.1%] and CRP [SMD: - 0.58, 95% CI - 0.1, - 0.17, I2: 0%].”

  Study

  meta-analysis

  Population

  participants in randomized clinical trials of glutamine supplementation

  Effect of glutamine supplementation on cardiometabolic risk factors and inflammatory markers: a systematic review and meta-analysis.2021PMID:33865313

• melatonin — no detected effect on

  BLikelyGrade B, Likely. Human evidence, limited replication or design limits.FindingNull result

  “However, the summary effect of melatonin on CRP was not significant (−0.18; −0.91, 0.55; p=0.62).”

  Study

  meta-analysis

  Population

  Adults in placebo-controlled clinical trials of exogenous melatonin, mixed clinical populations

  Anti-inflammatory effects of melatonin: A systematic review and meta-analysis of clinical trials.2021PMID:33581247

• curcumin — no detected effect on

  BLikelyGrade B, Likely. Human evidence, limited replication or design limits.FindingNull result

  “No statistically significant reduction in C-reactive protein was observed (SMD: -0.78; 95% CI: -1.58 to 0.05).”

  Study

  meta-analysis

  Participants

  303

  Population

  adults with type 2 diabetes mellitus (T2DM)

  Evaluating the Effects of Nanocurcumin Supplementation in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.2026PMID:42171191

• all-cis-5,8,11,14,17-icosapentaenoic acid — decreases

  BLikelyGrade B, Likely. Human evidence, limited replication or design limits.Finding

  “Serum ESR and CRP levels significantly decreased in the EPA-rich fish oil (p < 0.001).”

  Study

  RCT

  Participants

  24

  Duration

  3 weeks

  Dose

  1.5 g/day EPA as EPA-rich fish oil capsules (500 mg EPA per capsule, three times daily with meals)

  Population

  Hospitalised adults aged 18-65 with non-severe burns covering less than 20% of total body surface area, able to take more than 90% of their daily calorie requirement by mouth, without diabetes, organ failure, cancer or immune disorder; both the EPA arm and the control arm also received 600 mg/day DHA.

  Eicosapentaenoic acid decreases inflammation and improves glucose homeostasis in patients with burns: a randomized clinical trial.2025PMID:41254027

• creatine — no detected effect on

  BLikelyGrade B, Likely. Human evidence, limited replication or design limits.FindingNull result

  “Pooled analysis showed no significant acute effects of creatine on CRP (SMD = 0.32; 95% CI: -0.29 to 0.94; p = 0.30; I² = 28%).”

  Study

  meta-analysis

  Population

  healthy individuals, athletes and clinical populations

  Impact of creatine supplementation on inflammation: evidence from a systematic review and meta-analysis of randomized double-blind placebo trials.2026PMID:41798953