Endpoint
Intraventricular haemorrhage incidence
CAT:outcome/intraventricular-haemorrhage-incidencereported in risk ratio1 finding from 1 compound
What moved it
How to read these marks1 finding · 1 compound · 1 null · by evidence strength
| Compound | Direction | Findings | Strongest evidence |
|---|---|---|---|
| L-cysteine | no effect | 1 | Evidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers. |
Every finding here is a null result.
Measured, no effect detected
1 finding
L-cysteine — no detected effect on
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“No difference was found in the CYS and ISO groups with regards to the percent of subjects diagnosed with necrotizing enterocolitis (29% vs. 24%, p=1), intraventricular hemorrhage grade III and IV (19% vs. 24%, p=1), and need for laser treatment for retinopathy of prematurity (24% vs. 24%, p=1).”
Quoted verbatim from Effect of High-Dose Cysteine Supplementation on Erythrocyte Glutathione: A Double-Blinded, Randomized Placebo-Controlled Pilot Study in Critically Ill Neonates.. - Study
- RCT
- Dose
- cysteine-HCl 121 mg/kg/day in parenteral nutrition with sodium acetate 2 mEq/kg/day
- Population
- Critically ill neonates on mechanical ventilation and parenteral nutrition (SNAP > 10); severe grades III and IV only; comparator is isonitrogenous additional parenteral amino acids without cysteine
Effect of High-Dose Cysteine Supplementation on Erythrocyte Glutathione: A Double-Blinded, Randomized Placebo-Controlled Pilot Study in Critically Ill Neonates.2016PMID:25139979Permalink
How it is measured
Proportion of infants with intraventricular haemorrhage on cranial ultrasound, graded by the Papile classification. The grade counted as an event is recorded with each finding, since studies report either any grade or severe grades III-IV.
Sources cited
1 paper
- Subject
- intraventricular haemorrhage incidence
- Findings
- 1
- Papers
- 1