Endpoint
Hamilton Depression Rating Scale (HDRS) total score
CAT:outcome/hdrs-total-scorereported in points1 finding from 1 compound
What moved it
How to read these marks1 finding from 1 compound, best grade first.
| Compound | Direction | Findings | Best grade |
|---|---|---|---|
| magnesium(2+) | down | 1 | Grade D, Preliminary. Non-human or in vitro only. |
Reported to move it
1 finding
magnesium(2+) — decreases
PreliminaryGrade D, Preliminary. Non-human or in vitro only.Finding“The reduction in HDRS total score was greater in the intervention group than in the control group (-6.35 vs -2.80, p < 0.001), particularly in the domains of mood and insomnia.”
Quoted verbatim from Magnesium supplementation as an adjunct to fluoxetine therapy for depression.. - Study
- RCT
- Duration
- 6 weeks
- Dose
- magnesium 250 mg/day oral, adjunct to fluoxetine 20 mg/day
- Population
- adults aged 18-45 with new-onset or chronic depression, all receiving background fluoxetine 20 mg/day
Magnesium supplementation as an adjunct to fluoxetine therapy for depression.2026PMID:41916937
How it is measured
Total score on the clinician-administered Hamilton Depression Rating Scale (HDRS / HAM-D), summed across its items into a single continuous depression-severity score.
The method is part of the endpoint’s identity: two studies that measured the same word differently are held as separate endpoints.
Sources cited
1 paper
The 1 finding about hamilton depression rating scale (hdrs) total score on this page come from 1 paper, newest first. The count beside each opens the first finding drawn from it.