Compound
prostaglandin H2
A cyclic endoperoxide intermediate produced by the action of cyclooxygenase on arachidonic acid. It is further converted by a series of specific enzymes to the series 2 prostaglandins.
Structure
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- Class
- Organic compound, anion
- Formula
- C20H31O5
- Mass
- 351.463 g/mol
- Charge
- -1
- InChIKey
- YIBNHAJFJUQSRA-YNNPMVKQSA-M
- SMILES
- CCCCC[C@H](O)/C=C/[C@@H]1[C@@H](C/C=CCCCC(=O)[O-])[C@@H]2C[C@H]1OO2
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
14 entities
14 entities reached.
0 reported hops14 assembled from the scaffold
- PTGES3ProteinUNIPROT:Q15185substrate ofInferred only93 paths31 endpoints
- TBXAS1ProteinUNIPROT:P24557substrate ofInferred only92 paths23 endpoints
- PTGDSProteinUNIPROT:P41222substrate ofInferred only69 paths23 endpoints
- PTGES2ProteinUNIPROT:Q9H7Z7substrate ofInferred only44 paths11 endpoints
- SLCO2A1ProteinUNIPROT:Q92959transported byInferred only42 paths13 endpoints
- PTGESProteinUNIPROT:O14684substrate ofInferred only39 paths13 endpoints
- PTGISProteinUNIPROT:Q16647substrate ofInferred only36 paths18 endpoints
- AKR1C3ProteinUNIPROT:P42330substrate ofInferred only35 paths35 endpoints
- HPGDSProteinUNIPROT:O60760substrate ofInferred only33 paths11 endpoints
- CYP2S1ProteinUNIPROT:Q96SQ9metabolized byInferred only22 paths11 endpoints
- AKR1B1ProteinUNIPROT:P15121substrate ofInferred only22 paths22 endpoints
- CYP4F8ProteinUNIPROT:P98187metabolized byInferred only13 paths13 endpoints
What the reference databases state
Statements
53 statements
53 statements · 2 reference databases · Subject: prostaglandin H2 · Sources: Human-GEM, Rhea
- (5Z,8Z,11Z,14Z)-eicosatetraenoate is converted to prostaglandin H2CompoundHuman-GEM MAR08557Inferred only
- (5Z,8Z,11Z,14Z)-eicosatetraenoate is converted to prostaglandin H2CompoundHuman-GEM MAR08558Inferred only
- prostaglandin H2 is converted to prostaglandin D2CompoundHuman-GEM MAR01330Inferred only
- prostaglandin H2 is converted to prostaglandin D2CompoundHuman-GEM MAR08559Inferred only
- prostaglandin H2 is converted to prostaglandin D2CompoundRhea RHEA:10600Inferred only
- prostaglandin D2 is converted to prostaglandin H2CompoundHuman-GEM MAR08559Inferred only
- prostaglandin H2 is converted to prostaglandin E2CompoundHuman-GEM MAR08560Inferred only
- prostaglandin H2 is converted to prostaglandin E2CompoundRhea RHEA:12893Inferred only
- prostaglandin E2 is converted to prostaglandin H2CompoundHuman-GEM MAR08560Inferred only
- prostaglandin H2 is converted to prostaglandin E2CompoundHuman-GEM MAR01312Inferred only
- prostaglandin H2 is converted to prostaglandin F2alphaCompoundRhea RHEA:45312Inferred only
- prostaglandin F2alpha is converted to prostaglandin H2CompoundHuman-GEM MAR01325Inferred only
Show the remaining 41
- prostaglandin F2alpha is converted to prostaglandin H2CompoundHuman-GEM MAR01326Inferred only
- prostaglandin G2 is converted to prostaglandin H2CompoundHuman-GEM MAR01307Inferred only
- prostaglandin H2 is converted to prostaglandin I2CompoundHuman-GEM MAR01308Inferred only
- prostaglandin H2 is converted to prostaglandin I2CompoundRhea RHEA:23580Inferred only
- prostaglandin H2 is converted to thromboxane A2CompoundRhea RHEA:17137Inferred only
- prostaglandin H2 is converted to thromboxane A2CompoundHuman-GEM MAR01313Inferred only
- prostaglandin H2 is metabolised by CYP2S1ProteinRhea RHEA:48644Inferred only
- prostaglandin H2 is metabolised by CYP2S1ProteinRhea RHEA:17137Inferred only
- prostaglandin H2 is metabolised by CYP4F8ProteinRhea RHEA:48776Inferred only
- prostaglandin H2 is a substrate of AKR1B1ProteinRhea RHEA:45312Inferred only
- prostaglandin H2 is a substrate of AKR1C3ProteinRhea RHEA:45312Inferred only
- prostaglandin H2 is a substrate of HPGDSProteinRhea RHEA:10600Inferred only
- prostaglandin H2 is a substrate of HPGDSProteinHuman-GEM MAR01330Inferred only
- prostaglandin H2 is a substrate of HPGDSProteinHuman-GEM MAR08559Inferred only
- prostaglandin H2 is a substrate of PRXL2BProteinRhea RHEA:28214Inferred only
- prostaglandin H2 is a substrate of PTGDSProteinHuman-GEM MAR01330Inferred only
- prostaglandin H2 is a substrate of PTGDSProteinHuman-GEM MAR08559Inferred only
- prostaglandin H2 is a substrate of PTGDSProteinRhea RHEA:10600Inferred only
- prostaglandin H2 is a substrate of PTGESProteinHuman-GEM MAR08560Inferred only
- prostaglandin H2 is a substrate of PTGESProteinRhea RHEA:12893Inferred only
- prostaglandin H2 is a substrate of PTGESProteinHuman-GEM MAR01312Inferred only
- prostaglandin H2 is a substrate of PTGES2ProteinRhea RHEA:12893Inferred only
- prostaglandin H2 is a substrate of PTGES2ProteinRhea RHEA:48644Inferred only
- prostaglandin H2 is a substrate of PTGES2ProteinHuman-GEM MAR01312Inferred only
- prostaglandin H2 is a substrate of PTGES2ProteinHuman-GEM MAR08560Inferred only
- prostaglandin H2 is a substrate of PTGES3ProteinHuman-GEM MAR08560Inferred only
- prostaglandin H2 is a substrate of PTGES3ProteinHuman-GEM MAR01312Inferred only
- prostaglandin H2 is a substrate of PTGES3ProteinRhea RHEA:12893Inferred only
- prostaglandin H2 is a substrate of PTGISProteinHuman-GEM MAR01308Inferred only
- prostaglandin H2 is a substrate of PTGISProteinRhea RHEA:23580Inferred only
- prostaglandin H2 is a substrate of TBXAS1ProteinHuman-GEM MAR01313Inferred only
- prostaglandin H2 is a substrate of TBXAS1ProteinRhea RHEA:48644Inferred only
- prostaglandin H2 is a substrate of TBXAS1ProteinHuman-GEM MAR01339Inferred only
- prostaglandin H2 is a substrate of TBXAS1ProteinRhea RHEA:17137Inferred only
- prostaglandin H2 is transported by SLC22A10ProteinHuman-GEM MAR06273Inferred only
- prostaglandin H2 is transported by SLCO1B1ProteinHuman-GEM MAR06208Inferred only
- prostaglandin H2 is transported by SLCO1B1ProteinHuman-GEM MAR06210Inferred only
- prostaglandin H2 is transported by SLCO1B1ProteinHuman-GEM MAR06209Inferred only
- prostaglandin H2 is transported by SLCO2A1ProteinHuman-GEM MAR06239Inferred only
- prostaglandin H2 is transported by SLCO2A1ProteinHuman-GEM MAR08936Inferred only
- prostaglandin H2 is transported by SLCO2A1ProteinRhea RHEA:74379Inferred only
Reactions
31 reactions
2proton+prostaglandin G2water+prostaglandin H2
Reaction pageLeft to rightUnbalancedEC 1.14.99.1endoplasmic reticulum
Human-GEM MAR01307CC BY 4.0Reference data
prostaglandin H2prostaglandin I2
Catalysed by PTGIS
Reaction pageLeft to rightBalancedEC 5.3.99.4endoplasmic reticulum
Human-GEM MAR01308CC BY 4.0Reference data
prostaglandin H2prostaglandin H2
Reaction pageReversibleBalancedcytosol, endoplasmic reticulum
Human-GEM MAR01311CC BY 4.0Reference data
prostaglandin H2prostaglandin E2
Catalysed by PTGES3 or PTGES2 or PTGES
Reaction pageLeft to rightBalancedEC 5.3.99.3cytosol
Human-GEM MAR01312CC BY 4.0Reference data
prostaglandin H2thromboxane A2
Catalysed by TBXAS1
Reaction pageLeft to rightBalancedEC 5.3.99.5endoplasmic reticulum
Human-GEM MAR01313CC BY 4.0Reference data
NAD(+)+prostaglandin F2alphaproton+NADH(2-)+prostaglandin H2
Reaction pageLeft to rightBalancedEC 1.1.1.188cytosol
Human-GEM MAR01325CC BY 4.0Reference data
NADP(3-)+prostaglandin F2alphaproton+NADPH(4-)+prostaglandin H2
Catalysed by AKR1C3
Reaction pageLeft to rightBalancedEC 1.1.1.188cytosol
Human-GEM MAR01326CC BY 4.0Reference data
prostaglandin H2prostaglandin D2
Reaction pageLeft to rightBalancedEC 5.3.99.2cytosol
Human-GEM MAR01330CC BY 4.0Reference data
MAM00308c+proton+malonaldehydeprostaglandin H2
Catalysed by TBXAS1
Reaction pageReversibleBalancedEC 5.3.99.5cytosol
Human-GEM MAR01339CC BY 4.0Reference data
Reaction pageReversibleBalance undeterminableextracellular space
Human-GEM MAR04092CC BY 4.0Reference data
MAM01980c+hydrogencarbonate+prostaglandin H2MAM01980e+hydrogencarbonate+prostaglandin H2
Transported by SLCO1B1
Reaction pageReversibleBalance undeterminablecytosol, extracellular space
Human-GEM MAR06208CC BY 4.0Reference data
hydrogencarbonate+prostaglandin H2+2,4-dinitrophenyl-S-glutathionehydrogencarbonate+prostaglandin H2+2,4-dinitrophenyl-S-glutathione
Transported by SLCO1B1
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR06209CC BY 4.0Reference data
Where it reaches
5 systems, 8 regions, 15 tissues, 15 transporter routes — routes, not measurements: transporters known to carry prostaglandin H2 are expressed there, and no source reports it arriving.
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Other names
5 names
Resolves to: prostaglandin H2
- Also called
- PGH2prostaglandin H2 anion
- Systematic name
- (5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate(5Z,13E,15S)-9α,11α-epidioxy-15-hydroxyprosta-5,13-dienoate(5Z)-7-{(1R,4S,5R,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2,3-dioxabicyclo[2.2.1]hept-5-yl}hept-5-enoate