Compound
a sphingomyelin
A class of sphingolipids found largely in the brain and other nervous tissue. They contain phosphocholine or phosphoethanolamine as their polar head group so therefore are the only sphingolipids classified as phospholipids.
Structure
- Class
- Organic compound
- Formula
- C24H48N2O6PR
- Mass
- 491.622 g/mol
- Charge
- 0
- SMILES
- *C(=O)N[C@@H](COP(=O)([O-])OCC[N+](C)(C)C)[C@H](O)/C=C/CCCCCCCCCCCCC
- Look it up
- ChEBI
Identity from ChEBI. Not evidence.
What it touches on the way
Mechanistic reach
21 entities
21 entities reached.
0 reported hops21 assembled from the scaffold
- SMPD3ProteinUNIPROT:Q9NY59substrate ofInferred only65 paths13 endpoints
- SMPD1ProteinUNIPROT:P17405substrate ofInferred only48 paths16 endpoints
- ABCA1ProteinUNIPROT:O95477transported byInferred only47 paths47 endpoints
- PLTPProteinUNIPROT:P55058transported byInferred only44 paths44 endpoints
- SMPD2ProteinUNIPROT:O60906substrate ofInferred only42 paths14 endpoints
- ABCB1ProteinUNIPROT:P08183transported byInferred only42 paths20 endpoints
- SGMS2ProteinUNIPROT:Q8NHU3substrate ofInferred only28 paths10 endpoints
- PLIN1ProteinUNIPROT:O60240substrate ofInferred only25 paths25 endpoints
- SGMS1ProteinUNIPROT:Q86VZ5substrate ofInferred only20 paths10 endpoints
- PLIN2ProteinUNIPROT:Q99541substrate ofInferred only20 paths20 endpoints
- PLIN3ProteinUNIPROT:O60664substrate ofInferred only19 paths19 endpoints
- ENPP7ProteinUNIPROT:Q6UWV6substrate ofInferred only15 paths5 endpoints
Show the remaining 9
- SMPD4ProteinUNIPROT:Q9NXE4substrate ofInferred only15 paths5 endpoints
- ABCB4ProteinUNIPROT:P21439transported byInferred only8 paths7 endpoints
- PLIN4ProteinUNIPROT:Q96Q06substrate ofInferred only6 paths6 endpoints
- BSCL2ProteinUNIPROT:Q96G97substrate ofInferred only5 paths5 endpoints
- TMEM63BProteinUNIPROT:Q5T3F8transported byInferred only4 paths4 endpoints
- FITM2ProteinUNIPROT:Q8N6M3substrate ofInferred only3 paths3 endpoints
- FITM1ProteinUNIPROT:A5D6W6substrate ofInferred only3 paths3 endpoints
- ABCC1ProteinUNIPROT:P33527transported byInferred only2 paths2 endpoints
- ABCG1ProteinUNIPROT:P45844transported byInferred only1 path1 endpoint
What the reference databases state
Statements
37 statements
37 statements · 2 reference databases · Subject: a sphingomyelin · Sources: Human-GEM, Rhea
- a sphingomyelin is a substrate of BSCL2ProteinHuman-GEM MAR00031Inferred only
- a sphingomyelin is a substrate of ENPP7ProteinHuman-GEM MAR00797Inferred only
- a sphingomyelin is a substrate of ENPP7ProteinHuman-GEM MAR00795Inferred only
- a sphingomyelin is a substrate of ENPP7ProteinRhea RHEA:19253Inferred only
- a sphingomyelin is a substrate of FITM1ProteinHuman-GEM MAR00031Inferred only
- a sphingomyelin is a substrate of FITM2ProteinHuman-GEM MAR00031Inferred only
- a sphingomyelin is a substrate of PLIN1ProteinHuman-GEM MAR00031Inferred only
- a sphingomyelin is a substrate of PLIN2ProteinHuman-GEM MAR00031Inferred only
- a sphingomyelin is a substrate of PLIN3ProteinHuman-GEM MAR00031Inferred only
- a sphingomyelin is a substrate of PLIN4ProteinHuman-GEM MAR00031Inferred only
- a sphingomyelin is a substrate of SGMS1ProteinRhea RHEA:43320Inferred only
- a sphingomyelin is a substrate of SGMS1ProteinRhea RHEA:18765Inferred only
Show the remaining 25
- a sphingomyelin is a substrate of SGMS2ProteinRhea RHEA:43324Inferred only
- a sphingomyelin is a substrate of SGMS2ProteinRhea RHEA:18765Inferred only
- a sphingomyelin is a substrate of SGMS2ProteinRhea RHEA:43320Inferred only
- a sphingomyelin is a substrate of SMPD1ProteinHuman-GEM MAR00797Inferred only
- a sphingomyelin is a substrate of SMPD1ProteinRhea RHEA:19253Inferred only
- a sphingomyelin is a substrate of SMPD1ProteinHuman-GEM MAR00795Inferred only
- a sphingomyelin is a substrate of SMPD2ProteinRhea RHEA:19253Inferred only
- a sphingomyelin is a substrate of SMPD2ProteinHuman-GEM MAR00797Inferred only
- a sphingomyelin is a substrate of SMPD2ProteinHuman-GEM MAR00795Inferred only
- a sphingomyelin is a substrate of SMPD3ProteinHuman-GEM MAR00795Inferred only
- a sphingomyelin is a substrate of SMPD3ProteinRhea RHEA:19253Inferred only
- a sphingomyelin is a substrate of SMPD3ProteinHuman-GEM MAR00797Inferred only
- a sphingomyelin is a substrate of SMPD3ProteinHuman-GEM MAR08242Inferred only
- a sphingomyelin is a substrate of SMPD3ProteinHuman-GEM MAR12086Inferred only
- a sphingomyelin is a substrate of SMPD4ProteinRhea RHEA:19253Inferred only
- a sphingomyelin is a substrate of SMPD4ProteinHuman-GEM MAR00795Inferred only
- a sphingomyelin is a substrate of SMPD4ProteinHuman-GEM MAR00797Inferred only
- a sphingomyelin is transported by ABCA1ProteinRhea RHEA:38903Inferred only
- a sphingomyelin is transported by ABCB1ProteinHuman-GEM MAR11695Inferred only
- a sphingomyelin is transported by ABCB1ProteinRhea RHEA:38903Inferred only
- a sphingomyelin is transported by ABCB4ProteinRhea RHEA:38903Inferred only
- a sphingomyelin is transported by ABCC1ProteinHuman-GEM MAR11695Inferred only
- a sphingomyelin is transported by ABCG1ProteinRhea RHEA:38903Inferred only
- a sphingomyelin is transported by PLTPProteinRhea RHEA:39727Inferred only
- a sphingomyelin is transported by TMEM63BProteinRhea RHEA:39727Inferred only
Reactions
43 reactions
L-alanine+L-arginine+L-asparagine+L-aspartate+CHEBI:1307929+a cholesterol ester+a cardiolipin+MAM01602c+L-cysteine+MAM01721n+MAM01722n+L-glutamate(1-)+L-glutamine+glycine+CHEBI:15971+L-isoleucine+L-leucine+MAM02392c+CHEBI:18019+L-methionine+L-phenylalanine+phosphatidic acid+1-phosphatidyl-1D-myo-inositol+CHEBI:17203+MAM02847c+L-seryl residue+a sphingomyelin+CHEBI:16857+L-tryptophan+CHEBI:17895+L-valine+MAM03161cMAM03970c
Reaction pageBlockedBalance undeterminablecytosol, endoplasmic reticulum, nucleus
Human-GEM MAR00021CC BY 4.0Reference data
0.19a 1,2-diacyl-sn-glycerol+0.0014MAM00511c+0.0024a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine+0.00061-O-acyl-sn-glycero-3-phosphocholine(1+)+0.005CHEBI:1307929+0.34a cholesterol ester+0.00081-(alk-1-enyl)-2-acyl-sn-glycero-3-phosphoethanolamine+0.00921,2-diacyl-sn-glycero-3-phosphocholine(1+)+0.0034phosphatidylethanolamine+0.00161-phosphatidyl-1D-myo-inositol+0.0002phosphatidyl-L-serine+0.0004a sphingomyelin+0.44a triacylglycerol+0.005fatty acidMAM02392c
Catalysed by PLIN3 or FITM1 or PLIN2 or PLIN1 or PLIN4 or BSCL2 or FITM2
Reaction pageLeft to rightBalance undeterminablecytosol
Human-GEM MAR00031CC BY 4.0Reference data
an N-acylsphing-4-enine+1,2-diacyl-sn-glycero-3-phosphocholine(1+)a 1,2-diacyl-sn-glycerol+a sphingomyelin
Reaction pageLeft to rightBalance undeterminableEC 2.7.8.27Golgi apparatus
Human-GEM MAR00735CC BY 4.0Reference data
an N-acylsphing-4-enine+1,2-diacyl-sn-glycero-3-phosphocholine(1+)a 1,2-diacyl-sn-glycerol+a sphingomyelin
Reaction pageLeft to rightBalance undeterminableEC 2.7.8.27cytosol
Human-GEM MAR00736CC BY 4.0Reference data
CHEBI:16436+an N-acylsphing-4-eninecytidine 5'-monophosphate+proton+a sphingomyelin
Reaction pageReversibleBalance undeterminableEC 2.7.8.3endoplasmic reticulum
Human-GEM MAR00763CC BY 4.0Reference data
a sphingomyelina sphingomyelin
Reaction pageReversibleBalance undeterminablecytosol, endoplasmic reticulum
Human-GEM MAR00771CC BY 4.0Reference data
water+a sphingomyelinan N-acylsphing-4-enine+proton+CHEBI:18132
Catalysed by SMPD3 or SMPD2 or SMPD4 or SMPD1 or ENPP7
Reaction pageLeft to rightBalance undeterminableEC 3.1.4.12cytosol
Human-GEM MAR00795CC BY 4.0Reference data
a sphingomyelina sphingomyelin
Reaction pageReversibleBalance undeterminablecytosol, lysosome
Human-GEM MAR00796CC BY 4.0Reference data
water+a sphingomyelinan N-acylsphing-4-enine+proton+CHEBI:18132
Catalysed by SMPD3 or SMPD2 or SMPD4 or SMPD1 or ENPP7
Reaction pageLeft to rightBalance undeterminableEC 3.1.4.12lysosome
Human-GEM MAR00797CC BY 4.0Reference data
0.505626L-alanine+0.35926L-arginine+0.279425L-asparagine+0.352607L-aspartate+20.704451ATP+0.020401CHEBI:1307929+0.011658a cardiolipin+0.039036CHEBI:17677+0.046571L-cysteine+0.013183CHEBI:16284+0.009442dCTP+0.009898CHEBI:16497+0.013091dTTP+0.275194D-glucopyranose 6-phosphate+0.385872L-glutamate(1-)+0.325996L-glutamine+0.538891glycine+0.036117GTP+20.650823water+0.126406CHEBI:15971+0.286078L-isoleucine+0.545544L-leucine+0.592114CHEBI:18019+0.153018L-methionine+0.1544631,2-diacyl-sn-glycero-3-phosphocholine(1+)+0.055374phosphatidylethanolamine+0.002914MAM02715c+0.259466L-phenylalanine+0.0233151-phosphatidyl-1D-myo-inositol+0.412484CHEBI:17203+0.005829phosphatidyl-L-serine+0.392525L-seryl residue+0.017486a sphingomyelin+0.31269CHEBI:16857+0.013306L-tryptophan+0.159671CHEBI:17895+0.053446UTP+0.352607L-valine20.650823ADP+20.650823proton+20.650823phosphate(3-)+MAM03970c
Reaction pageBlockedBalance undeterminablecytosol, nucleus
Human-GEM MAR04413CC BY 4.0Reference data
MAM02047l2MAM01350l+30proton+901,2-diacyl-sn-glycero-3-phosphocholine(1+)+25phosphatidylethanolamine+30phosphatidyl-L-serine+75a sphingomyelin
Reaction pageLeft to rightBalance undeterminablelysosome
Human-GEM MAR05233CC BY 4.0Reference data
2MAM01350r+20CHEBI:1307929+160a cholesterol ester+30proton+901,2-diacyl-sn-glycero-3-phosphocholine(1+)+25phosphatidylethanolamine+30phosphatidyl-L-serine+75a sphingomyelinMAM02048r
Reaction pageLeft to rightBalance undeterminableendoplasmic reticulum
Human-GEM MAR05234CC BY 4.0Reference data
Where it reaches
9 systems, 21 regions, 54 tissues, 62 transporter routes — routes, not measurements: transporters known to carry a sphingomyelin are expressed there, and no source reports it arriving.
Loading the model…
Other names
7 names
Resolves to: a sphingomyelin
- Also called
- ceramide phosphocholineN-acyl-4-sphingenyl-1-O-phosphorylcholinesN-acyl-sphing-4-enine-1-phosphocholineSM(d18:1(4E))SphingomyelinSphingomyelin (d18:1(4E))sphingomyelins