Compound
prostaglandin F2alpha
A naturally occurring prostaglandin that has oxytocic, luteolytic, and abortifacient activities. Due to its vasocontractile properties, the compound has a variety of other biological actions.
Structure
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- Class
- Organic compound, anion
- Formula
- C20H33O5
- Mass
- 353.479 g/mol
- Charge
- -1
- InChIKey
- PXGPLTODNUVGFL-YNNPMVKQSA-M
- SMILES
- CCCCC[C@H](O)/C=C/[C@@H]1[C@@H](C/C=CCCCC(=O)[O-])[C@@H](O)C[C@H]1O
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
15 entities
15 entities reached.
0 reported hops15 assembled from the scaffold
- AKR1C3ProteinUNIPROT:P42330substrate ofInferred only105 paths35 endpoints
- CBR1ProteinUNIPROT:P16152substrate ofInferred only44 paths22 endpoints
- SLCO2A1ProteinUNIPROT:Q92959transported byInferred only42 paths13 endpoints
- HPGDProteinUNIPROT:P15428substrate ofInferred only17 paths17 endpoints
- PRXL2BProteinUNIPROT:Q8TBF2substrate ofInferred only10 paths10 endpoints
- SLC22A2ProteinUNIPROT:O15244transported byInferred only10 paths5 endpoints
- SLCO1B1ProteinUNIPROT:Q9Y6L6transported byInferred only9 paths2 endpoints
- CBR3ProteinUNIPROT:O75828substrate ofInferred only9 paths9 endpoints
- DHRS4ProteinUNIPROT:Q9BTZ2substrate ofInferred only7 paths7 endpoints
- SLC22A1ProteinUNIPROT:O15245transported byInferred only6 paths3 endpoints
- SLCO3A1ProteinUNIPROT:Q9UIG8transported byInferred only3 paths3 endpoints
- SLC22A8ProteinUNIPROT:Q8TCC7transported byInferred only2 paths1 endpoint
What the reference databases state
Chemical structure
- prostaglandin F2alpha has the functional parent prostaglandin F2alpha-CoACompoundChEBI CHEBI:57404Inferred only
Statements
39 statements
39 statements · 2 reference databases · Subject: prostaglandin F2alpha · Sources: Human-GEM, Rhea
- 15-oxoprostaglandin F2alpha is converted to prostaglandin F2alphaCompoundHuman-GEM MAR09934Inferred only
- prostaglandin F2alpha is converted to 15-oxoprostaglandin F2alphaCompoundHuman-GEM MAR01328Inferred only
- prostaglandin F2alpha is converted to 15-oxoprostaglandin F2alphaCompoundHuman-GEM MAR09934Inferred only
- prostaglandin F2alpha is converted to 15-oxoprostaglandin F2alphaCompoundRhea RHEA:63480Inferred only
- 15-oxoprostaglandin F2alpha is converted to prostaglandin F2alphaCompoundHuman-GEM MAR01328Inferred only
- prostaglandin D2 is converted to prostaglandin F2alphaCompoundRhea RHEA:10140Inferred only
- prostaglandin D2 is converted to prostaglandin F2alphaCompoundHuman-GEM MAR01329Inferred only
- prostaglandin F2alpha is converted to prostaglandin D2CompoundHuman-GEM MAR01329Inferred only
- prostaglandin F2alpha is converted to prostaglandin E2CompoundHuman-GEM MAR01327Inferred only
- prostaglandin E2 is converted to prostaglandin F2alphaCompoundRhea RHEA:24508Inferred only
- prostaglandin F2alpha-CoA is converted to prostaglandin F2alphaCompoundRhea RHEA:59948Inferred only
- prostaglandin F2alpha is converted to prostaglandin H2CompoundHuman-GEM MAR01326Inferred only
Show the remaining 27
- prostaglandin F2alpha is converted to prostaglandin H2CompoundHuman-GEM MAR01325Inferred only
- prostaglandin H2 is converted to prostaglandin F2alphaCompoundRhea RHEA:45312Inferred only
- prostaglandin F2alpha is a substrate of AKR1C3ProteinHuman-GEM MAR01327Inferred only
- prostaglandin F2alpha is a substrate of AKR1C3ProteinHuman-GEM MAR01326Inferred only
- prostaglandin F2alpha is a substrate of AKR1C3ProteinHuman-GEM MAR01329Inferred only
- prostaglandin F2alpha is a substrate of CBR1ProteinRhea RHEA:63480Inferred only
- prostaglandin F2alpha is a substrate of CBR1ProteinHuman-GEM MAR01327Inferred only
- prostaglandin F2alpha is a substrate of CBR3ProteinHuman-GEM MAR01327Inferred only
- prostaglandin F2alpha is a substrate of DHRS4ProteinHuman-GEM MAR01327Inferred only
- prostaglandin F2alpha is a substrate of HPGDProteinHuman-GEM MAR09934Inferred only
- prostaglandin F2alpha is a substrate of PRXL2BProteinRhea RHEA:28214Inferred only
- prostaglandin F2alpha is transported by SLC22A1ProteinHuman-GEM MAR06247Inferred only
- prostaglandin F2alpha is transported by SLC22A1ProteinRhea RHEA:50988Inferred only
- prostaglandin F2alpha is transported by SLC22A11ProteinRhea RHEA:50988Inferred only
- prostaglandin F2alpha is transported by SLC22A2ProteinHuman-GEM MAR06247Inferred only
- prostaglandin F2alpha is transported by SLC22A2ProteinRhea RHEA:50988Inferred only
- prostaglandin F2alpha is transported by SLC22A6ProteinRhea RHEA:76119Inferred only
- prostaglandin F2alpha is transported by SLC22A7ProteinRhea RHEA:50988Inferred only
- prostaglandin F2alpha is transported by SLC22A8ProteinRhea RHEA:72503Inferred only
- prostaglandin F2alpha is transported by SLC22A8ProteinRhea RHEA:72507Inferred only
- prostaglandin F2alpha is transported by SLCO1B1ProteinHuman-GEM MAR06199Inferred only
- prostaglandin F2alpha is transported by SLCO1B1ProteinHuman-GEM MAR06200Inferred only
- prostaglandin F2alpha is transported by SLCO1B1ProteinHuman-GEM MAR06201Inferred only
- prostaglandin F2alpha is transported by SLCO2A1ProteinHuman-GEM MAR06247Inferred only
- prostaglandin F2alpha is transported by SLCO2A1ProteinRhea RHEA:74399Inferred only
- prostaglandin F2alpha is transported by SLCO2A1ProteinHuman-GEM MAR06236Inferred only
- prostaglandin F2alpha is transported by SLCO3A1ProteinRhea RHEA:50988Inferred only
Reactions
24 reactions
NAD(+)+prostaglandin F2alphaproton+NADH(2-)+prostaglandin H2
Reaction pageLeft to rightBalancedEC 1.1.1.188cytosol
Human-GEM MAR01325CC BY 4.0Reference data
NADP(3-)+prostaglandin F2alphaproton+NADPH(4-)+prostaglandin H2
Catalysed by AKR1C3
Reaction pageLeft to rightBalancedEC 1.1.1.188cytosol
Human-GEM MAR01326CC BY 4.0Reference data
NADP(3-)+prostaglandin F2alphaproton+NADPH(4-)+prostaglandin E2
Catalysed by DHRS4 or CBR1 or CBR3 or AKR1C3
Reaction pageLeft to rightBalancedEC 1.1.1.184, 1.1.1.189cytosol
Human-GEM MAR01327CC BY 4.0Reference data
15-oxoprostaglandin F2alpha+proton+NADH(2-)NAD(+)+prostaglandin F2alpha
Reaction pageReversibleBalancedcytosol
Human-GEM MAR01328CC BY 4.0Reference data
proton+NADPH(4-)+prostaglandin D2NADP(3-)+prostaglandin F2alpha
Catalysed by AKR1C3
Reaction pageReversibleBalancedEC 1.1.1.188cytosol
Human-GEM MAR01329CC BY 4.0Reference data
MAM01980c+hydrogencarbonate+prostaglandin F2alphaMAM01980e+hydrogencarbonate+prostaglandin F2alpha
Transported by SLCO1B1
Reaction pageReversibleBalance undeterminablecytosol, extracellular space
Human-GEM MAR06199CC BY 4.0Reference data
hydrogencarbonate+prostaglandin F2alpha+2,4-dinitrophenyl-S-glutathionehydrogencarbonate+prostaglandin F2alpha+2,4-dinitrophenyl-S-glutathione
Transported by SLCO1B1
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR06200CC BY 4.0Reference data
hydrogencarbonate+prostaglandin F2alpha+MAM02901chydrogencarbonate+prostaglandin F2alpha+MAM02901e
Transported by SLCO1B1
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR06201CC BY 4.0Reference data
CHEBI:16856+hydrogencarbonate+prostaglandin F2alphaCHEBI:16856+hydrogencarbonate+prostaglandin F2alpha
Transported by SLCO2A1
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR06236CC BY 4.0Reference data
prostaglandin F2alphaprostaglandin F2alpha
Transported by SLC22A2 or SLCO2A1 or SLC22A1
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR06247CC BY 4.0Reference data
Reaction pageReversibleBalance undeterminableextracellular space
Human-GEM MAR09398CC BY 4.0Reference data
NAD(+)+prostaglandin F2alpha15-oxoprostaglandin F2alpha+proton+NADH(2-)
Catalysed by HPGD
Reaction pageReversibleBalancedEC 1.1.1.141, 1.1.1.196cytosol
Human-GEM MAR09934CC BY 4.0Reference data
Where it reaches
6 systems, 11 regions, 19 tissues, 24 transporter routes — routes, not measurements: transporters known to carry prostaglandin F2alpha are expressed there, and no source reports it arriving.
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Other names
6 names
Resolves to: prostaglandin F2alpha
- Also called
- PGF2Prostaglandin F2prostaglandin F2alpha anionprostaglandin F2α anion
- Systematic name
- (5Z,13E,15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dien-1-oate(5Z,13E,15S)-9α,11α,15-trihydroxyprosta-5,13-dien-1-oate