Compound
lithocholic acid
A bile acid formed from chenodeoxycholate by bacterial action, usually conjugated with glycine or taurine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is used as cholagogue and choleretic.
What it touches on the way
Mechanistic reach
12 entities
12 entities reached.
0 reported hops12 assembled from the scaffold
- CYP3A4ProteinUNIPROT:P08684metabolized byInferred only106 paths53 endpoints
- BAATProteinUNIPROT:Q14032substrate ofInferred only76 paths19 endpoints
- UGT2B7ProteinUNIPROT:P16662metabolized byInferred only64 paths16 endpoints
- CYP8B1ProteinUNIPROT:Q9UNU6metabolized byInferred only52 paths26 endpoints
- ABCC3ProteinUNIPROT:O15438transported byInferred only33 paths30 endpoints
- UGT2A1ProteinUNIPROT:P0DTE4metabolized byInferred only32 paths8 endpoints
- UGT2A3ProteinUNIPROT:Q6UWM9metabolized byInferred only32 paths8 endpoints
- UGT1A3ProteinUNIPROT:P35503metabolized byInferred only30 paths15 endpoints
- SULT2A1ProteinUNIPROT:Q06520metabolized byInferred only24 paths24 endpoints
- SLCO1B3ProteinUNIPROT:Q9NPD5transported byInferred only12 paths2 endpoints
- ABCB11ProteinUNIPROT:O95342transported byInferred only4 paths3 endpoints
- SLC10A1ProteinUNIPROT:Q14973transported byInferred only2 paths2 endpoints
What the reference databases state
Chemical structure
- glycolithocholic acid has the functional parent lithocholic acidCompoundChEBI CHEBI:37998Inferred only
Statements
38 statements
38 statements · 1 reference database · Subject: lithocholic acid · Sources: Human-GEM
- lithocholic acid is converted to deoxycholateCompoundHuman-GEM MAR01840Inferred only
- lithocholic acid is converted to deoxycholateCompoundHuman-GEM MAR01839Inferred only
- lithocholic acid is converted to hyodeoxycholateCompoundHuman-GEM MAR01838Inferred only
- lithocholic acid is metabolised by CYP3A4ProteinHuman-GEM MAR01838Inferred only
- lithocholic acid is metabolised by CYP3A4ProteinHuman-GEM MAR12158Inferred only
- lithocholic acid is metabolised by CYP8B1ProteinHuman-GEM MAR01839Inferred only
- lithocholic acid is metabolised by CYP8B1ProteinHuman-GEM MAR01840Inferred only
- lithocholic acid is metabolised by SULT2A1ProteinHuman-GEM MAR12282Inferred only
- lithocholic acid is metabolised by UGT1A3ProteinHuman-GEM MAR12272Inferred only
- lithocholic acid is metabolised by UGT1A3ProteinHuman-GEM MAR12273Inferred only
- lithocholic acid is metabolised by UGT2A1ProteinHuman-GEM MAR12277Inferred only
- lithocholic acid is metabolised by UGT2A1ProteinHuman-GEM MAR12272Inferred only
Show the remaining 26
- lithocholic acid is metabolised by UGT2A1ProteinHuman-GEM MAR12273Inferred only
- lithocholic acid is metabolised by UGT2A1ProteinHuman-GEM MAR12276Inferred only
- lithocholic acid is metabolised by UGT2A3ProteinHuman-GEM MAR12273Inferred only
- lithocholic acid is metabolised by UGT2A3ProteinHuman-GEM MAR12276Inferred only
- lithocholic acid is metabolised by UGT2A3ProteinHuman-GEM MAR12277Inferred only
- lithocholic acid is metabolised by UGT2A3ProteinHuman-GEM MAR12272Inferred only
- lithocholic acid is metabolised by UGT2B7ProteinHuman-GEM MAR12272Inferred only
- lithocholic acid is metabolised by UGT2B7ProteinHuman-GEM MAR12276Inferred only
- lithocholic acid is metabolised by UGT2B7ProteinHuman-GEM MAR12273Inferred only
- lithocholic acid is metabolised by UGT2B7ProteinHuman-GEM MAR12277Inferred only
- lithocholic acid is a substrate of BAATProteinHuman-GEM MAR01844Inferred only
- lithocholic acid is a substrate of BAATProteinHuman-GEM MAR01841Inferred only
- lithocholic acid is a substrate of BAATProteinHuman-GEM MAR01845Inferred only
- lithocholic acid is a substrate of BAATProteinHuman-GEM MAR01842Inferred only
- lithocholic acid is transported by ABCB11ProteinHuman-GEM MAR10010Inferred only
- lithocholic acid is transported by ABCC11ProteinHuman-GEM MAR10010Inferred only
- lithocholic acid is transported by ABCC3ProteinHuman-GEM MAR10010Inferred only
- lithocholic acid is transported by SLC10A1ProteinHuman-GEM MAR10011Inferred only
- lithocholic acid is transported by SLCO1A2ProteinHuman-GEM MAR06068Inferred only
- lithocholic acid is transported by SLCO1A2ProteinHuman-GEM MAR06060Inferred only
- lithocholic acid is transported by SLCO1A2ProteinHuman-GEM MAR06070Inferred only
- lithocholic acid is transported by SLCO1A2ProteinHuman-GEM MAR06069Inferred only
- lithocholic acid is transported by SLCO1B3ProteinHuman-GEM MAR06069Inferred only
- lithocholic acid is transported by SLCO1B3ProteinHuman-GEM MAR06070Inferred only
- lithocholic acid is transported by SLCO1B3ProteinHuman-GEM MAR06060Inferred only
- lithocholic acid is transported by SLCO1B3ProteinHuman-GEM MAR06068Inferred only
Reactions
22 reactions
2proton+lithocholic acid+NADPH(4-)+dioxygenwater+hyodeoxycholate+NADP(3-)
Catalysed by CYP3A4
Reaction pageLeft to rightBalancedEC 1.14.14.57GO:0005829
Human-GEM MAR01838CC BY 4.0Reference data
proton+lithocholic acid+NADPH(4-)+dioxygendeoxycholate+water+NADP(3-)
Catalysed by CYP8B1
Reaction pageLeft to rightBalancedEC 1.14.14.139GO:0005829
Human-GEM MAR01839CC BY 4.0Reference data
proton+lithocholic acid+NADPH(4-)+dioxygendeoxycholate+water+NADP(3-)
Catalysed by CYP8B1
Reaction pageLeft to rightBalancedEC 1.14.14.139GO:0005783
Human-GEM MAR01840CC BY 4.0Reference data
ATP+lithocholic acid+taurineAMP+proton+diphosphate(3-)+taurolithocholate
Catalysed by BAAT
Reaction pageLeft to rightBalancedEC 6.2.1.-, 2.3.1.65GO:0005829
Human-GEM MAR01841CC BY 4.0Reference data
ATP+lithocholic acid+taurineAMP+proton+diphosphate(3-)+taurolithocholate
Catalysed by BAAT
Reaction pageLeft to rightBalancedEC 6.2.1.-, 2.3.1.65GO:0005777
Human-GEM MAR01842CC BY 4.0Reference data
ATP+glycine+lithocholic acidAMP+glycolithocholic acid+proton+diphosphate(3-)
Catalysed by BAAT
Reaction pageLeft to rightBalancedEC 6.2.1.-, 2.3.1.65GO:0005829
Human-GEM MAR01844CC BY 4.0Reference data
ATP+glycine+lithocholic acidAMP+glycolithocholic acid+proton+diphosphate(3-)
Catalysed by BAAT
Reaction pageLeft to rightBalancedEC 6.2.1.-, 2.3.1.65GO:0005777
Human-GEM MAR01845CC BY 4.0Reference data
Reaction pageReversibleBalance undeterminableGO:0005615
Human-GEM MAR04164CC BY 4.0Reference data
CHEBI:16856+hydrogencarbonate+lithocholic acidCHEBI:16856+hydrogencarbonate+lithocholic acid
Transported by SLCO1A2 & SLCO1B3
Reaction pageReversibleBalancedGO:0005829, GO:0005615
Human-GEM MAR06060CC BY 4.0Reference data
MAM01980c+hydrogencarbonate+lithocholic acidMAM01980e+hydrogencarbonate+lithocholic acid
Transported by SLCO1A2 & SLCO1B3
Reaction pageReversibleBalance undeterminableGO:0005829, GO:0005615
Human-GEM MAR06068CC BY 4.0Reference data
hydrogencarbonate+lithocholic acid+2,4-dinitrophenyl-S-glutathionehydrogencarbonate+lithocholic acid+2,4-dinitrophenyl-S-glutathione
Transported by SLCO1A2 & SLCO1B3
Reaction pageReversibleBalancedGO:0005829, GO:0005615
Human-GEM MAR06069CC BY 4.0Reference data
hydrogencarbonate+lithocholic acid+MAM02901chydrogencarbonate+lithocholic acid+MAM02901e
Transported by SLCO1A2 & SLCO1B3
Reaction pageReversibleBalancedGO:0005829, GO:0005615
Human-GEM MAR06070CC BY 4.0Reference data
Where it reaches
7 systems, 15 regions, 30 tissues, 35 transporter routes — routes, not measurements: transporters known to carry lithocholic acid are expressed there, and no source reports it arriving.
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Other names
11 names
Resolves to: lithocholic acid
- Also called
- (3alpha,5beta)-3-hydroxycholan-24-oic acid(3α,5β)-3-hydroxycholan-24-oic acid3alpha-Hydroxy-5beta-cholanate3alpha-Hydroxy-5beta-cholanic acid3alpha-hydroxy-5beta-cholanoic acid3α-hydroxy-5β-cholanic acid3α-hydroxy-5β-cholanoic acid5beta-cholanic acid-3alpha-ol5β-cholanic acid-3α-ol
- Systematic name
- 3alpha-hydroxy-5beta-cholan-24-oic acid3α-hydroxy-5β-cholan-24-oic acid