What it touches on the way
Mechanistic reach
8 entities
8 entities reached.
0 reported hops8 assembled from the scaffold
- SLC29A1ProteinUNIPROT:Q99808transported byInferred only43 paths43 endpoints
- DPYDProteinUNIPROT:Q12882substrate ofInferred only20 paths10 endpoints
- UPP1ProteinUNIPROT:Q16831substrate ofInferred only18 paths9 endpoints
- UPP2ProteinUNIPROT:O95045substrate ofInferred only14 paths7 endpoints
- AQP9ProteinUNIPROT:O43315transported byInferred only8 paths7 endpoints
- SLC29A2ProteinUNIPROT:Q14542transported byInferred only6 paths3 endpoints
- RPUSD4ProteinUNIPROT:Q96CM3substrate ofInferred only5 paths5 endpoints
- UPRTProteinUNIPROT:Q96BW1substrate ofInferred only1 path1 endpoint
What the reference databases state
Chemical structure
- 2'-deoxyuridine has the functional parent uracilCompoundChEBI CHEBI:16450Inferred only
- 5-hydroxymethyluracil has the functional parent uracilCompoundChEBI CHEBI:16964Inferred only
- 5,6-dihydrouracil has the functional parent uracilCompoundChEBI CHEBI:15901Inferred only
- orotate has the functional parent uracilCompoundChEBI CHEBI:30839Inferred only
- orotic acid has the functional parent uracilCompoundChEBI CHEBI:16742Inferred only
- uridine has the functional parent uracilCompoundChEBI CHEBI:16704Inferred only
Statements
25 statements
25 statements · 2 reference databases · Subject: uracil · Sources: Human-GEM, Rhea
- 5,6-dihydrouracil is converted to uracilCompoundHuman-GEM MAR04345Inferred only
- 5,6-dihydrouracil is converted to uracilCompoundHuman-GEM MAR04344Inferred only
- uracil is converted to 5,6-dihydrouracilCompoundRhea RHEA:18093Inferred only
- uracil is converted to 5,6-dihydrouracilCompoundRhea RHEA:12384Inferred only
- uracil is converted to 5,6-dihydrouracilCompoundHuman-GEM MAR04345Inferred only
- uracil is converted to 5,6-dihydrouracilCompoundHuman-GEM MAR04344Inferred only
- uracil is converted to 5,6-dihydrouracilCompoundRhea RHEA:20189Inferred only
- 5,6-dihydrouracil is converted to uracilCompoundRhea RHEA:20189Inferred only
- 5,6-dihydrouracil is converted to uracilCompoundRhea RHEA:12384Inferred only
- cytosine is converted to uracilCompoundRhea RHEA:20605Inferred only
- uracil is converted to cytosineCompoundRhea RHEA:20605Inferred only
- cytosine is converted to uracilCompoundHuman-GEM MAR08637Inferred only
Show the remaining 13
- uracil is a substrate of DPYDProteinRhea RHEA:18093Inferred only
- uracil is a substrate of DPYDProteinHuman-GEM MAR04345Inferred only
- uracil is a substrate of RPUSD4ProteinHuman-GEM MAR07744Inferred only
- uracil is a substrate of UPP1ProteinHuman-GEM MAR04680Inferred only
- uracil is a substrate of UPP1ProteinHuman-GEM MAR04579Inferred only
- uracil is a substrate of UPP2ProteinHuman-GEM MAR04680Inferred only
- uracil is a substrate of UPP2ProteinHuman-GEM MAR04579Inferred only
- uracil is a substrate of UPRTProteinHuman-GEM MAR04343Inferred only
- uracil is transported by AQP9ProteinRhea RHEA:69404Inferred only
- uracil is transported by SLC29A1ProteinRhea RHEA:69404Inferred only
- uracil is transported by SLC29A2ProteinRhea RHEA:69404Inferred only
- uracil is transported by SLC29A2ProteinHuman-GEM MAR04882Inferred only
- uracil is transported by SLC29A3ProteinRhea RHEA:69404Inferred only
Reactions
31 reactions
5-phospho-alpha-D-ribose 1-diphosphate+uracildiphosphate(3-)+UMP
Catalysed by UPRT
Reaction pageLeft to rightBalancedEC 2.4.2.9cytosol
Human-GEM MAR04343CC BY 4.0Reference data
5,6-dihydrouracil+NAD(+)proton+NADH(2-)+uracil
Reaction pageReversibleBalancedEC 1.3.1.1cytosol
Human-GEM MAR04344CC BY 4.0Reference data
5,6-dihydrouracil+NADP(3-)proton+NADPH(4-)+uracil
Catalysed by DPYD
Reaction pageReversibleBalancedEC 1.3.1.2cytosol
Human-GEM MAR04345CC BY 4.0Reference data
phosphate(3-)+uridineD-ribose 1-phosphate+uracil
Reaction pageReversibleBalancedEC 2.4.2.3cytosol
Human-GEM MAR04579CC BY 4.0Reference data
MAM00639c+uracil2'-deoxyuridine+phosphate(3-)
Reaction pageReversibleBalancedEC 2.4.2.3cytosol
Human-GEM MAR04680CC BY 4.0Reference data
Transported by SLC29A2
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR04882CC BY 4.0Reference data
water+MAM02807cCHEBI:17797+uracil
Catalysed by RPUSD4
Reaction pageReversibleBalancedEC 4.2.1.70cytosol
Human-GEM MAR07744CC BY 4.0Reference data
Reaction pageLeft to rightBalancedcytosol
Human-GEM MAR08637CC BY 4.0Reference data
Reaction pageReversibleBalance undeterminableextracellular space
Human-GEM MAR09437CC BY 4.0Reference data
CHEBI:58340+uracilCHEBI:57543+acetate+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:11496CC BY 4.0Reference data
5,6-dihydrouracil+dioxygenuracil+hydrogen peroxide
Reaction pageDirection not assertedBalanced
Rhea RHEA:12384CC BY 4.0Reference data
UMP+diphosphate(3-)5-phospho-alpha-D-ribose 1-diphosphate+uracil
Reaction pageDirection not assertedBalanced
Rhea RHEA:13017CC BY 4.0Reference data
Where it reaches
7 systems, 17 regions, 48 tissues, 50 transporter routes — routes, not measurements: transporters known to carry uracil are expressed there, and no source reports it arriving.
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Other names
6 names
Resolves to: uracil
- Also called
- 2,4-Dioxopyrimidine2,4-Pyrimidinedione2,4(1H,3H)-pyrimidinedioneUraUrazil
- Systematic name
- pyrimidine-2,4(1H,3H)-dione