Compound

butanoyl-CoA

An acyl-CoA(4−) that is the tetraanion of butyryl-CoA, arising from deprotonation of phosphate and diphosphate functions.

Definition from ChEBI (CHEBI:57371), read 2026-09-23. CC BY 4.0.

CHEBI:57371ChEBI

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Structure

2D depiction

No three-dimensional record for this entry.

Class: Organic compound, anion
Formula: C25H38N7O17P3S
Mass: 833.6 g/mol
Charge: -4
InChIKey: CRFNGMNYKDXRTN-CITAKDKDSA-J
SMILES: CCCC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(=O)([O-])OP(=O)([O-])OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1OP(=O)([O-])[O-]
Look it up: ChEBI By InChIKey

Identity from ChEBI. Not evidence.

What it touches on the way

Mechanistic reach

28 entities

28 entities reached.

0 reported hops28 assembled from the scaffold

Show the remaining 16

What the reference databases state

Statements

52 statements

52 statements · 2 reference databases · Subject: butanoyl-CoA · Sources: Human-GEM, Rhea

Order

butanoyl-CoA is converted to (2E)-butenoyl-CoACompoundRhea RHEA:27906Inferred only
butanoyl-CoA is converted to (2E)-butenoyl-CoACompoundRhea RHEA:41964Inferred only
butanoyl-CoA is converted to (2E)-butenoyl-CoACompoundRhea RHEA:30731Inferred only
butanoyl-CoA is converted to (2E)-butenoyl-CoACompoundRhea RHEA:52572Inferred only
butanoyl-CoA is converted to (2E)-butenoyl-CoACompoundHuman-GEM MAR03163Inferred only
(2E)-butenoyl-CoA is converted to butanoyl-CoACompoundRhea RHEA:27906Inferred only
(2E)-butenoyl-CoA is converted to butanoyl-CoACompoundRhea RHEA:30731Inferred only
(2E)-butenoyl-CoA is converted to butanoyl-CoACompoundRhea RHEA:41964Inferred only
(2E)-butenoyl-CoA is converted to butanoyl-CoACompoundRhea RHEA:52572Inferred only
2-methylpropanoyl-CoA is converted to butanoyl-CoACompoundRhea RHEA:13141Inferred only
butanoyl-CoA is converted to 2-methylpropanoyl-CoACompoundRhea RHEA:13141Inferred only
3-oxohexanoyl-CoA is converted to butanoyl-CoACompoundRhea RHEA:31111Inferred only

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butanoyl-CoA is converted to butanalCompoundRhea RHEA:22972Inferred only
butanal is converted to butanoyl-CoACompoundRhea RHEA:22968Inferred only
butanal is converted to butanoyl-CoACompoundRhea RHEA:22972Inferred only
butanoyl-CoA is converted to butanalCompoundRhea RHEA:22968Inferred only
butanoyl-CoA is converted to butanoateCompoundRhea RHEA:40111Inferred only
butanoate is converted to butanoyl-CoACompoundRhea RHEA:46172Inferred only
butanoyl-CoA is converted to S-butanoyl-4'-phosphopantetheineCompoundRhea RHEA:49976Inferred only
butanoyl-CoA is a substrate of ACAA2ProteinRhea RHEA:40111Inferred only
butanoyl-CoA is a substrate of ACADSProteinHuman-GEM MAR03163Inferred only
butanoyl-CoA is a substrate of ACADSProteinRhea RHEA:24004Inferred only
butanoyl-CoA is a substrate of ACADSBProteinRhea RHEA:24004Inferred only
butanoyl-CoA is a substrate of ACADSBProteinHuman-GEM MAR03163Inferred only
butanoyl-CoA is a substrate of ACOT11ProteinRhea RHEA:40111Inferred only
butanoyl-CoA is a substrate of ACOT12ProteinHuman-GEM MAR20169Inferred only
butanoyl-CoA is a substrate of ACOT12ProteinRhea RHEA:40111Inferred only
butanoyl-CoA is a substrate of ACOT13ProteinRhea RHEA:40111Inferred only
butanoyl-CoA is a substrate of ACOT8ProteinRhea RHEA:40111Inferred only
butanoyl-CoA is a substrate of ACOT9ProteinRhea RHEA:40111Inferred only
butanoyl-CoA is a substrate of CPT1AProteinHuman-GEM MAR00159Inferred only
butanoyl-CoA is a substrate of CPT1BProteinHuman-GEM MAR00159Inferred only
butanoyl-CoA is a substrate of CPT1CProteinHuman-GEM MAR00159Inferred only
butanoyl-CoA is a substrate of CPT2ProteinHuman-GEM MAR00161Inferred only
butanoyl-CoA is a substrate of CRATProteinRhea RHEA:44980Inferred only
butanoyl-CoA is a substrate of CRATProteinHuman-GEM MAR00161Inferred only
butanoyl-CoA is a substrate of CROTProteinHuman-GEM MAR04678Inferred only
butanoyl-CoA is a substrate of EP300ProteinRhea RHEA:53912Inferred only
butanoyl-CoA is a substrate of IVDProteinRhea RHEA:24004Inferred only
butanoyl-CoA is a substrate of KAT2AProteinRhea RHEA:53912Inferred only
butanoyl-CoA is a substrate of MBOAT4ProteinRhea RHEA:68276Inferred only
butanoyl-CoA is a substrate of MOGAT1ProteinRhea RHEA:77271Inferred only
butanoyl-CoA is a substrate of MOGAT2ProteinRhea RHEA:77271Inferred only
butanoyl-CoA is a substrate of NUDT19ProteinRhea RHEA:49976Inferred only
butanoyl-CoA is a substrate of NUDT7ProteinRhea RHEA:49976Inferred only
butanoyl-CoA is a substrate of NUDT8ProteinRhea RHEA:49976Inferred only
butanoyl-CoA is a substrate of PCCAProteinRhea RHEA:59520Inferred only
butanoyl-CoA is a substrate of PCCBProteinRhea RHEA:59520Inferred only
butanoyl-CoA is a substrate of PHYHProteinRhea RHEA:55176Inferred only
butanoyl-CoA is transported by ESCO2ProteinHuman-GEM MAR00158Inferred only
butanoyl-CoA is transported by OXSMProteinHuman-GEM MAR00158Inferred only
butanoyl-CoA is transported by SLC33A1ProteinHuman-GEM MAR00158Inferred only

Reactions

51 reactions

ATP+butyric acid+CHEBI:1146900AMP+butanoyl-CoA+diphosphate(3-)
Catalysed by ACSM3 or ACSM2B or ACSM1 or ACSM5 or ACSM2A or ACSM4
Reaction pageLeft to rightBalancedEC 6.2.1.2cytosol
Human-GEM MAR00156CC BY 4.0Reference data
butanoyl-CoAbutanoyl-CoA
Reaction pageLeft to rightBalancedcytosol, mitochondrial matrix
Human-GEM MAR00157CC BY 4.0Reference data
butanoyl-CoA+(S)-carnitinebutanoyl-CoA+(S)-carnitine
Transported by OXSM or SLC33A1 or ESCO2
Reaction pageReversibleBalancedmitochondrial matrix, cytosol
Human-GEM MAR00158CC BY 4.0Reference data
butanoyl-CoA+(S)-carnitineCHEBI:1146900+MAM02635c
Catalysed by CPT1A or CPT1C or CPT1B
Reaction pageReversibleBalancedEC 2.3.1.21cytosol
Human-GEM MAR00159CC BY 4.0Reference data
CHEBI:1146900+MAM02635mbutanoyl-CoA+(S)-carnitine
Catalysed by CRAT or CPT2
Reaction pageReversibleBalancedEC 2.3.1.7mitochondrial matrix
Human-GEM MAR00161CC BY 4.0Reference data
ATP+butyric acid+CHEBI:1146900AMP+butanoyl-CoA+diphosphate(3-)
Catalysed by ACSM1
Reaction pageLeft to rightBalancedEC 6.2.1.2mitochondrial matrix
Human-GEM MAR00742CC BY 4.0Reference data
3-oxohexanoyl-CoA+CHEBI:1146900CHEBI:15351+butanoyl-CoA
Catalysed by ACAA1 & MYO5B
Reaction pageLeft to rightBalancedEC 2.3.1.16peroxisome
Human-GEM MAR03101CC BY 4.0Reference data
3-oxohexanoyl-CoA+CHEBI:1146900CHEBI:15351+butanoyl-CoA
Catalysed by HADHA & ACAA2 & HADHB
Reaction pageLeft to rightBalancedEC 2.3.1.16, 1.1.1.211mitochondrial matrix
Human-GEM MAR03160CC BY 4.0Reference data
butanoyl-CoA+FAD(2E)-butenoyl-CoA+FADH2
Catalysed by ACADS or ACADSB
Reaction pageLeft to rightBalancedEC 1.3.8.7mitochondrial matrix
Human-GEM MAR03163CC BY 4.0Reference data
butanoyl-CoA+(S)-carnitineCHEBI:1146900+MAM02635x
Catalysed by CROT
Reaction pageReversibleBalancedperoxisome
Human-GEM MAR04678CC BY 4.0Reference data
(2E)-hexenoyl-CoA+CHEBI:1146900+water+NAD(+)CHEBI:15351+butanoyl-CoA+proton+NADH(2-)
Catalysed by ACAA1 & HSD17B4 & EHHADH
Reaction pageLeft to rightBalancedperoxisome
Human-GEM MAR06280CC BY 4.0Reference data
CHEBI:1146900+FAD+water+CHEBI:27540+NAD(+)CHEBI:15351+butanoyl-CoA+FADH2+proton+NADH(2-)
Catalysed by ACAA1 & HSD17B4 & EHHADH & ACOX1
Reaction pageLeft to rightBalancedperoxisome
Human-GEM MAR06284CC BY 4.0Reference data

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Where it reaches

1 system, 1 region, 1 tissue, 1 transporter route — routes, not measurements: transporters known to carry butanoyl-CoA are expressed there, and no source reports it arriving.

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Reproductive

Other names

6 names

Resolves to: butanoyl-CoA

Also called: butanoyl-coenzyme A(4-)butanoyl-coenzyme A(4−)butyryl-coenzyme A tetraanionbutyryl-coenzyme A(4-)butyryl-coenzyme A(4−)
Systematic name: 3'-phosphonatoadenosine 5'-(3-{(3R)-4-[(3-{[2-(butanoylsulfanyl)ethyl]amino}-3-oxopropyl)amino]-3-hydroxy-2,2-dimethyl-4-oxobutyl} diphosphate)