Compound
putrescine
A toxic diamine formed by putrefaction from the decarboxylation of arginine and ornithine.
Structure
Loading the model…
- Class
- Organic compound, cation
- Formula
- C4H14N2
- Mass
- 90.17 g/mol
- Charge
- +2
- InChIKey
- KIDHWZJUCRJVML-UHFFFAOYSA-P
- SMILES
- [NH3+]CCCC[NH3+]
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
16 entities
16 entities reached.
0 reported hops16 assembled from the scaffold
- SAT1ProteinUNIPROT:P21673substrate ofInferred only54 paths54 endpoints
- AOC1ProteinUNIPROT:P19801substrate ofInferred only36 paths12 endpoints
- HDAC10ProteinUNIPROT:Q969S8substrate ofInferred only25 paths25 endpoints
- SRMProteinUNIPROT:P19623substrate ofInferred only22 paths11 endpoints
- SLC7A7ProteinUNIPROT:Q9UM01transported byInferred only16 paths16 endpoints
- ATP13A3ProteinUNIPROT:Q9H7F0transported byInferred only14 paths14 endpoints
- ODC1ProteinUNIPROT:P11926substrate ofInferred only13 paths13 endpoints
- SLC3A2ProteinUNIPROT:P08195transported byInferred only12 paths12 endpoints
- PAOXProteinUNIPROT:Q6QHF9substrate ofInferred only10 paths10 endpoints
- AOC2ProteinUNIPROT:O75106substrate ofInferred only6 paths3 endpoints
- AOC3ProteinUNIPROT:Q16853substrate ofInferred only5 paths5 endpoints
- ATP13A4ProteinUNIPROT:Q4VNC1transported byInferred only5 paths5 endpoints
Show the remaining 4
What the reference databases state
Statements
33 statements
33 statements · 2 reference databases · Subject: putrescine · Sources: Human-GEM, Rhea
- putrescine is converted to 4-aminobutanalCompoundRhea RHEA:23816Inferred only
- putrescine is converted to 4-aminobutanalCompoundRhea RHEA:18273Inferred only
- 4-aminobutanal is converted to putrescineCompoundRhea RHEA:23816Inferred only
- putrescine is converted to CHEBI:17769CompoundHuman-GEM MAR08606Inferred only
- putrescine is converted to CHEBI:17769CompoundHuman-GEM MAR04423Inferred only
- D-ornithine is converted to putrescineCompoundRhea RHEA:59048Inferred only
- putrescine is converted to D-ornithineCompoundRhea RHEA:59048Inferred only
- L-ornithine is converted to putrescineCompoundHuman-GEM MAR04212Inferred only
- L-ornithine is converted to putrescineCompoundHuman-GEM MAR04422Inferred only
- L-ornithine is converted to putrescineCompoundRhea RHEA:22964Inferred only
- putrescine is converted to L-ornithineCompoundRhea RHEA:22964Inferred only
- putrescine is converted to N-acetylputrescineCompoundRhea RHEA:25181Inferred only
Show the remaining 21
- N-acetylputrescine is converted to putrescineCompoundRhea RHEA:25181Inferred only
- putrescine is a substrate of AOC1ProteinRhea RHEA:18273Inferred only
- putrescine is a substrate of AOC1ProteinHuman-GEM MAR08606Inferred only
- putrescine is a substrate of AOC1ProteinHuman-GEM MAR04423Inferred only
- putrescine is a substrate of AOC2ProteinHuman-GEM MAR04423Inferred only
- putrescine is a substrate of AOC2ProteinHuman-GEM MAR08606Inferred only
- putrescine is a substrate of AOC3ProteinHuman-GEM MAR04423Inferred only
- putrescine is a substrate of HDAC10ProteinRhea RHEA:23412Inferred only
- putrescine is a substrate of ODC1ProteinRhea RHEA:22964Inferred only
- putrescine is a substrate of PAOXProteinRhea RHEA:25812Inferred only
- putrescine is a substrate of SAT1ProteinHuman-GEM MAR08603Inferred only
- putrescine is a substrate of SAT2ProteinHuman-GEM MAR08603Inferred only
- putrescine is a substrate of SRMProteinRhea RHEA:12721Inferred only
- putrescine is a substrate of SRMProteinHuman-GEM MAR04075Inferred only
- putrescine is transported by ATP13A3ProteinRhea RHEA:29995Inferred only
- putrescine is transported by ATP13A4ProteinRhea RHEA:29995Inferred only
- putrescine is transported by SLC22A1ProteinRhea RHEA:72135Inferred only
- putrescine is transported by SLC22A2ProteinRhea RHEA:72135Inferred only
- putrescine is transported by SLC3A2ProteinHuman-GEM MAR11804Inferred only
- putrescine is transported by SLC45A4ProteinRhea RHEA:72135Inferred only
- putrescine is transported by SLC7A7ProteinHuman-GEM MAR11804Inferred only
Reactions
41 reactions
putrescine+S-adenosylmethioninamineS-methyl-5'-thioadenosine+proton+spermidine
Catalysed by SRM
Reaction pageLeft to rightBalancedEC 2.5.1.16cytosol
Human-GEM MAR04075CC BY 4.0Reference data
proton+L-ornithinecarbon dioxide+putrescine
Catalysed by ODC1
Reaction pageLeft to rightBalancedEC 4.1.1.17cytosol
Human-GEM MAR04212CC BY 4.0Reference data
proton+L-ornithinecarbon dioxide+putrescine
Catalysed by ODC1
Reaction pageLeft to rightBalancedEC 4.1.1.17extracellular space
Human-GEM MAR04422CC BY 4.0Reference data
water+dioxygen+putrescineCHEBI:17769+proton+hydrogen peroxide+ammonium
Catalysed by AOC1 or AOC3 or AOC2
Reaction pageLeft to rightBalancedEC 1.4.3.10, 1.4.3.21, 1.4.3.22extracellular space
Human-GEM MAR04423CC BY 4.0Reference data
Catalysed by AGMAT
Reaction pageLeft to rightBalancedEC 3.5.3.11mitochondrial matrix
Human-GEM MAR04424CC BY 4.0Reference data
Reaction pageReversibleBalancedcytosol, mitochondrial matrix
Human-GEM MAR04959CC BY 4.0Reference data
water+CHEBI:17927+dioxygen3-acetamidopropanal+hydrogen peroxide+putrescine
Reaction pageLeft to rightBalancedEC 1.5.3.13, 1.5.3.16cytosol
Human-GEM MAR06961CC BY 4.0Reference data
FAD+water+CHEBI:179273-acetamidopropanal+FADH2+putrescine
Reaction pageLeft to rightBalancedEC 1.5.3.13, 1.5.3.16peroxisome
Human-GEM MAR06962CC BY 4.0Reference data
CHEBI:15351+putrescineCHEBI:1146900+proton+N-acetylputrescine
Reaction pageLeft to rightBalancedEC 2.3.1.57cytosol
Human-GEM MAR08603CC BY 4.0Reference data
water+dioxygen+putrescineCHEBI:17769+proton+hydrogen peroxide+ammonium
Reaction pageLeft to rightBalancedEC 1.4.3.22cytosol
Human-GEM MAR08606CC BY 4.0Reference data
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR08989CC BY 4.0Reference data
Reaction pageReversibleBalance undeterminableextracellular space
Human-GEM MAR11426CC BY 4.0Reference data
Where it reaches
8 systems, 14 regions, 35 tissues, 37 transporter routes — routes, not measurements: transporters known to carry putrescine are expressed there, and no source reports it arriving.
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Other names
4 names
Resolves to: putrescine
- Also called
- butane-1,4-diaminiumputrescinium dicationputrescinium(2+)
- Systematic name
- butane-1,4-bis(aminium)