Compound
CHEBI:15765
The naturally occurring form of dihydroxyphenylalanine and the immediate precursor of dopamine. Unlike dopamine itself, it can be taken orally and crosses the blood-brain barrier. It is rapidly taken up by dopaminergic neurons and converted to dopamine. It is used for the treatment of parkinsonian disorders and is usually given with agents that inhibit its conversion to dopamine outside of the central nervous system.
What it touches on the way
Mechanistic reach
5 entities
5 entities reached.
0 reported hops5 assembled from the scaffold
- COMTProteinUNIPROT:P21964metabolized byInferred only35 paths35 endpoints
- DDCProteinUNIPROT:P20711substrate ofInferred only19 paths19 endpoints
- SLC3A2ProteinUNIPROT:P08195transported byInferred only12 paths12 endpoints
- TYRProteinUNIPROT:P14679substrate ofInferred only11 paths11 endpoints
- SLC7A5ProteinUNIPROT:Q01650transported byInferred only8 paths8 endpoints
What the reference databases state
Statements
11 statements
11 statements · 1 reference database · Subject: CHEBI:15765 · Sources: Human-GEM
- CHEBI:17895 is converted to CHEBI:15765CompoundHuman-GEM MAR06729Inferred only
- CHEBI:17895 is converted to CHEBI:15765CompoundHuman-GEM MAR08541Inferred only
- CHEBI:15765 is converted to dopamineCompoundHuman-GEM MAR06731Inferred only
- CHEBI:15765 is converted to L-dopaquinoneCompoundHuman-GEM MAR08542Inferred only
- CHEBI:15765 is metabolised by COMTProteinHuman-GEM MAR06730Inferred only
- CHEBI:15765 is a substrate of DDCProteinHuman-GEM MAR06731Inferred only
- CHEBI:15765 is a substrate of LRTOMTProteinHuman-GEM MAR06730Inferred only
- CHEBI:15765 is a substrate of TYRProteinHuman-GEM MAR08542Inferred only
- CHEBI:15765 is transported by SLC16A10ProteinHuman-GEM MAR08081Inferred only
- CHEBI:15765 is transported by SLC3A2ProteinHuman-GEM MAR06859Inferred only
- CHEBI:15765 is transported by SLC7A5ProteinHuman-GEM MAR06859Inferred only
Reactions
12 reactions
dioxygen+5,6,7,8-tetrahydrobiopterin+CHEBI:17895MAM01698c+water+CHEBI:15765
Catalysed by TH
Reaction pageLeft to rightBalancedEC 1.14.16.2GO:0005829
Human-GEM MAR06728CC BY 4.0Reference data
2proton+dioxygen+CHEBI:17895water+CHEBI:15765
Catalysed by TYR
Reaction pageLeft to rightUnbalancedEC 1.14.18.1GO:0005829
Human-GEM MAR06729CC BY 4.0Reference data
CHEBI:15765+S-adenosyl-L-methionineMAM00830c+proton+CHEBI:16680
Reaction pageLeft to rightBalancedEC 2.1.1.6GO:0005829
Human-GEM MAR06730CC BY 4.0Reference data
proton+CHEBI:15765carbon dioxide+dopamine
Catalysed by DDC
Reaction pageLeft to rightBalancedEC 4.1.1.28GO:0005829
Human-GEM MAR06731CC BY 4.0Reference data
CHEBI:15765+L-leucineCHEBI:15765+L-leucine
Transported by SLC3A2 & SLC7A5
Reaction pageLeft to rightBalancedGO:0005615, GO:0005829
Human-GEM MAR06859CC BY 4.0Reference data
MAM00638c+L-dopaquinoneCHEBI:15765+MAM02355c
Reaction pageReversibleBalancedGO:0005829
Human-GEM MAR06876CC BY 4.0Reference data
MAM01043c+CHEBI:15765MAM01134c+L-dopaquinone
Reaction pageReversibleBalancedGO:0005829
Human-GEM MAR06878CC BY 4.0Reference data
Transported by SLC16A10
Reaction pageReversibleBalancedGO:0005829, GO:0005615
Human-GEM MAR08081CC BY 4.0Reference data
dioxygen+5,6,7,8-tetrahydrobiopterin+CHEBI:178954a-hydroxytetrahydrobiopterin+CHEBI:15765
Catalysed by TH
Reaction pageLeft to rightBalancedEC 1.14.16.2GO:0005829
Human-GEM MAR08537CC BY 4.0Reference data
dioxygen+2CHEBI:178952CHEBI:15765
Catalysed by TYR
Reaction pageLeft to rightBalancedEC 1.14.18.1GO:0005829
Human-GEM MAR08541CC BY 4.0Reference data
2CHEBI:15765+dioxygen2water+2L-dopaquinone
Catalysed by TYR
Reaction pageLeft to rightBalancedEC 1.14.18.1GO:0005829
Human-GEM MAR08542CC BY 4.0Reference data
Reaction pageReversibleBalance undeterminableGO:0005615
Human-GEM MAR09219CC BY 4.0Reference data
Where it reaches
4 systems, 6 regions, 8 tissues, 8 transporter routes — routes, not measurements: transporters known to carry CHEBI:15765 are expressed there, and no source reports it arriving.
Loading the model…
Other names
17 names
Resolves to: CHEBI:15765
- Also called
- (-)-3-(3,4-dihydroxyphenyl)-L-alanine(-)-dopa(−)-3-(3,4-dihydroxyphenyl)-L-alanine(−)-dopa3-Hydroxy-L-tyrosine3,4-Dihydroxy-L-phenylalanine3,4-DIHYDROXYPHENYLALANINEbeta-(3,4-dihydroxyphenyl)-L-alaninebeta-(3,4-dihydroxyphenyl)alanineDihydroxy-L-phenylalanineL-beta-(3,4-Dihydroxyphenyl)alaninelevodopaβ-(3,4-dihydroxyphenyl)-L-alanineβ-(3,4-dihydroxyphenyl)alanine
- Systematic name
- (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acidL-dopa
- Sold as
- Dopar