What it touches on the way
Mechanistic reach
16 entities
16 entities reached.
0 reported hops16 assembled from the scaffold
- DHFRProteinUNIPROT:P00374substrate ofInferred only93 paths31 endpoints
- SHMT2ProteinUNIPROT:P34897substrate ofInferred only30 paths30 endpoints
- SHMT1ProteinUNIPROT:P34896substrate ofInferred only22 paths22 endpoints
- ATICProteinUNIPROT:P31939substrate ofInferred only21 paths21 endpoints
- MTHFD1ProteinUNIPROT:P11586substrate ofInferred only19 paths19 endpoints
- DHFR2ProteinUNIPROT:Q86XF0substrate ofInferred only15 paths5 endpoints
- MTHFD2ProteinUNIPROT:P13995substrate ofInferred only13 paths13 endpoints
- GCSHProteinUNIPROT:P23434substrate ofInferred only11 paths11 endpoints
- HNMTProteinUNIPROT:P50135substrate ofInferred only11 paths11 endpoints
- AMTProteinUNIPROT:P48728substrate ofInferred only8 paths8 endpoints
- FTCDProteinUNIPROT:O95954substrate ofInferred only7 paths7 endpoints
- MTHFD1LProteinUNIPROT:Q6UB35substrate ofInferred only7 paths7 endpoints
Show the remaining 4
What the reference databases state
Chemical structure
- 5-methyltetrahydrofolic acid has the functional parent 5,6,7,8-tetrahydrofolic acidCompoundChEBI CHEBI:15641Inferred only
Statements
31 statements
31 statements · 1 reference database · Subject: 5,6,7,8-tetrahydrofolic acid · Sources: Human-GEM
- 10-formyltetrahydrofolic acid is converted to 5,6,7,8-tetrahydrofolic acidCompoundHuman-GEM MAR04336Inferred only
- 5,6,7,8-tetrahydrofolic acid is converted to 5-methyltetrahydrofolic acidCompoundHuman-GEM MAR03915Inferred only
- 5,6,7,8-tetrahydrofolic acid is converted to 7,8-dihydrofolateCompoundHuman-GEM MAR04335Inferred only
- 7,8-dihydrofolate is converted to 5,6,7,8-tetrahydrofolic acidCompoundHuman-GEM MAR04332Inferred only
- 7,8-dihydrofolate is converted to 5,6,7,8-tetrahydrofolic acidCompoundHuman-GEM MAR04333Inferred only
- 7,8-dihydrofolate is converted to 5,6,7,8-tetrahydrofolic acidCompoundHuman-GEM MAR04335Inferred only
- 5,6,7,8-tetrahydrofolic acid is converted to 7,8-dihydrofolateCompoundHuman-GEM MAR04332Inferred only
- 5,6,7,8-tetrahydrofolic acid is converted to 7,8-dihydrofolateCompoundHuman-GEM MAR04333Inferred only
- 5,6,7,8-tetrahydrofolic acid is a substrate of AMTProteinHuman-GEM MAR08434Inferred only
- 5,6,7,8-tetrahydrofolic acid is a substrate of ATICProteinHuman-GEM MAR04814Inferred only
- 5,6,7,8-tetrahydrofolic acid is a substrate of DHFRProteinHuman-GEM MAR04332Inferred only
- 5,6,7,8-tetrahydrofolic acid is a substrate of DHFRProteinHuman-GEM MAR04335Inferred only
Show the remaining 19
- 5,6,7,8-tetrahydrofolic acid is a substrate of DHFRProteinHuman-GEM MAR04333Inferred only
- 5,6,7,8-tetrahydrofolic acid is a substrate of DHFR2ProteinHuman-GEM MAR04333Inferred only
- 5,6,7,8-tetrahydrofolic acid is a substrate of DHFR2ProteinHuman-GEM MAR04332Inferred only
- 5,6,7,8-tetrahydrofolic acid is a substrate of DHFR2ProteinHuman-GEM MAR04335Inferred only
- 5,6,7,8-tetrahydrofolic acid is a substrate of FPGSProteinHuman-GEM MAR05392Inferred only
- 5,6,7,8-tetrahydrofolic acid is a substrate of FPGSProteinHuman-GEM MAR08115Inferred only
- 5,6,7,8-tetrahydrofolic acid is a substrate of FPGSProteinHuman-GEM MAR08108Inferred only
- 5,6,7,8-tetrahydrofolic acid is a substrate of FTCDProteinHuman-GEM MAR04658Inferred only
- 5,6,7,8-tetrahydrofolic acid is a substrate of GCSHProteinHuman-GEM MAR08434Inferred only
- 5,6,7,8-tetrahydrofolic acid is a substrate of HNMTProteinHuman-GEM MAR03915Inferred only
- 5,6,7,8-tetrahydrofolic acid is a substrate of MTHFD1ProteinHuman-GEM MAR04338Inferred only
- 5,6,7,8-tetrahydrofolic acid is a substrate of MTHFD1LProteinHuman-GEM MAR04340Inferred only
- 5,6,7,8-tetrahydrofolic acid is a substrate of MTHFD2ProteinHuman-GEM MAR04340Inferred only
- 5,6,7,8-tetrahydrofolic acid is a substrate of MTHFD2LProteinHuman-GEM MAR04340Inferred only
- 5,6,7,8-tetrahydrofolic acid is a substrate of SARDHProteinHuman-GEM MAR08432Inferred only
- 5,6,7,8-tetrahydrofolic acid is a substrate of SHMT1ProteinHuman-GEM MAR03845Inferred only
- 5,6,7,8-tetrahydrofolic acid is a substrate of SHMT2ProteinHuman-GEM MAR04792Inferred only
- 5,6,7,8-tetrahydrofolic acid is transported by SLC19A1ProteinHuman-GEM MAR07685Inferred only
- 5,6,7,8-tetrahydrofolic acid is transported by SLC19A1ProteinHuman-GEM MAR01780Inferred only
Reactions
33 reactions
MAM00209m+biotin+CHEBI:1146900+MAM01600m+ferroheme c di-L-cysteine(2-) residue+FADH2+(S)-carnitine+NADH(2-)+NADPH(4-)+riboflavin+5,6,7,8-tetrahydrobiopterin+5,6,7,8-tetrahydrofolic acid+ubiquinol+0.1MAM03139c+0.1MAM03140c+0.1MAM03143cMAM01602c
Reaction pageLeft to rightBalance undeterminablemitochondrial matrix, cytosol
Human-GEM MAR00022CC BY 4.0Reference data
water+5,6,7,8-tetrahydrofolic acidwater+5,6,7,8-tetrahydrofolic acid
Transported by SLC19A1
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR01780CC BY 4.0Reference data
L-seryl residue+5,6,7,8-tetrahydrofolic acid(6R)-5,10-methylenetetrahydrofolic acid+glycine+water
Catalysed by SHMT1
Reaction pageReversibleBalancedEC 2.1.2.1cytosol
Human-GEM MAR03845CC BY 4.0Reference data
S-adenosyl-L-methionine+5,6,7,8-tetrahydrofolic acid5-methyltetrahydrofolic acid+CHEBI:16680
Catalysed by HNMT
Reaction pageLeft to rightBalancedEC 2.1.1.8cytosol
Human-GEM MAR03915CC BY 4.0Reference data
5-methyltetrahydrofolic acid+homocysteineproton+L-methionine+5,6,7,8-tetrahydrofolic acid
Catalysed by MTR
Reaction pageLeft to rightBalancedEC 2.1.1.13cytosol
Human-GEM MAR03917CC BY 4.0Reference data
5,6,7,8-tetrahydrofolic acid5,6,7,8-tetrahydrofolic acid
Reaction pageReversibleBalancedcytosol, mitochondrial matrix
Human-GEM MAR03952CC BY 4.0Reference data
formaldehyde+5,6,7,8-tetrahydrofolic acid(6R)-5,10-methylenetetrahydrofolic acid+water
Reaction pageLeft to rightBalancedcytosol
Human-GEM MAR03972CC BY 4.0Reference data
5-methyltetrahydrofolic acid+Se-methylselenocysteineproton+selenomethionine+5,6,7,8-tetrahydrofolic acid
Reaction pageLeft to rightBalancedEC 2.1.1.13nucleus
Human-GEM MAR04011CC BY 4.0Reference data
5-methyltetrahydrofolic acid+Se-methylselenocysteineproton+selenomethionine+5,6,7,8-tetrahydrofolic acid
Reaction pageLeft to rightBalancedEC 2.1.1.13endoplasmic reticulum
Human-GEM MAR04013CC BY 4.0Reference data
7,8-dihydrofolate+proton+NADH(2-)NAD(+)+5,6,7,8-tetrahydrofolic acid
Reaction pageReversibleBalancedEC 1.5.1.3cytosol
Human-GEM MAR04332CC BY 4.0Reference data
7,8-dihydrofolate+proton+NADPH(4-)NADP(3-)+5,6,7,8-tetrahydrofolic acid
Reaction pageReversibleBalancedEC 1.5.1.3cytosol
Human-GEM MAR04333CC BY 4.0Reference data
7,8-dihydrofolate+proton+NADPH(4-)NADP(3-)+5,6,7,8-tetrahydrofolic acid
Reaction pageReversibleBalancedEC 1.5.1.3mitochondrial matrix
Human-GEM MAR04335CC BY 4.0Reference data
Where it reaches
1 system, 1 region, 1 tissue, 1 transporter route — routes, not measurements: transporters known to carry 5,6,7,8-tetrahydrofolic acid are expressed there, and no source reports it arriving.
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Other names
8 names
Resolves to: 5,6,7,8-tetrahydrofolic acid
- Also called
- (6S)-Tetrahydrofolate(6S)-Tetrahydrofolic acid(6S)-THFA5,6,7,8-Tetrahydrofolatetetrahydrofolatetetrahydrofolic acidTHF
- Systematic name
- N-[4-{[(2-amino-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}benzoyl]-L-glutamic acid