Structure
Loading the model…
- Class
- Organic compound
- Formula
- C15H13I2NO4
- Mass
- 525.08 g/mol
- Charge
- 0
- InChIKey
- CPCJBZABTUOGNM-LBPRGKRZSA-N
- SMILES
- [NH3+][C@@H](Cc1ccc(Oc2ccc(O)c(I)c2)c(I)c1)C(=O)[O-]
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
40 entities
40 entities reached.
0 reported hops40 assembled from the scaffold
- DIO2ProteinUNIPROT:Q92813substrate ofInferred only72 paths18 endpoints
- UGT1A4ProteinUNIPROT:P22310metabolized byInferred only40 paths20 endpoints
- DIO1ProteinUNIPROT:P49895substrate ofInferred only40 paths8 endpoints
- UGT1A1ProteinUNIPROT:P22309metabolized byInferred only34 paths17 endpoints
- SLC43A1ProteinUNIPROT:O75387transported byInferred only33 paths33 endpoints
- UGT1A9ProteinUNIPROT:O60656metabolized byInferred only32 paths16 endpoints
- STSProteinUNIPROT:P08842substrate ofInferred only28 paths14 endpoints
- DIO3ProteinUNIPROT:P55073substrate ofInferred only27 paths9 endpoints
- UGT1A7ProteinUNIPROT:Q9HAW7metabolized byInferred only24 paths12 endpoints
- UGT2B4ProteinUNIPROT:P06133metabolized byInferred only22 paths11 endpoints
- UGT1A6ProteinUNIPROT:P19224metabolized byInferred only20 paths10 endpoints
- UGT2B15ProteinUNIPROT:P54855metabolized byInferred only20 paths10 endpoints
Show the remaining 28
- UGT1A10ProteinUNIPROT:Q9HAW8metabolized byInferred only19 paths10 endpoints
- SLC7A8ProteinUNIPROT:Q9UHI5transported byInferred only18 paths18 endpoints
- UGT2B17ProteinUNIPROT:O75795metabolized byInferred only18 paths9 endpoints
- UGT2B11ProteinUNIPROT:O75310metabolized byInferred only16 paths8 endpoints
- UGT2B7ProteinUNIPROT:P16662metabolized byInferred only16 paths8 endpoints
- UGT1A5ProteinUNIPROT:P35504metabolized byInferred only16 paths8 endpoints
- UGT1A3ProteinUNIPROT:P35503metabolized byInferred only14 paths7 endpoints
- UGT2B10ProteinUNIPROT:P36537metabolized byInferred only14 paths7 endpoints
- UGT2A3ProteinUNIPROT:Q6UWM9metabolized byInferred only13 paths8 endpoints
- SLC43A2ProteinUNIPROT:Q8N370transported byInferred only13 paths13 endpoints
- UGT3A2ProteinUNIPROT:Q3SY77metabolized byInferred only12 paths6 endpoints
- UGT3A1ProteinUNIPROT:Q6NUS8metabolized byInferred only12 paths6 endpoints
- SULT1C2ProteinUNIPROT:O00338metabolized byInferred only12 paths12 endpoints
- SULT1B1ProteinUNIPROT:O43704metabolized byInferred only12 paths6 endpoints
- SULT1A1ProteinUNIPROT:P50225metabolized byInferred only12 paths12 endpoints
- CHST10ProteinUNIPROT:O43529substrate ofInferred only10 paths10 endpoints
- SULT1A3ProteinUNIPROT:P0DMM9metabolized byInferred only10 paths10 endpoints
- UGT1A8ProteinUNIPROT:Q9HAW9metabolized byInferred only9 paths5 endpoints
- UGT2A1ProteinUNIPROT:P0DTE4metabolized byInferred only9 paths5 endpoints
- SLC7A5ProteinUNIPROT:Q01650transported byInferred only8 paths8 endpoints
- SULT1C4ProteinUNIPROT:O75897metabolized byInferred only8 paths8 endpoints
- SULT1A4ProteinUNIPROT:P0DMN0metabolized byInferred only8 paths8 endpoints
- NDST1ProteinUNIPROT:P52848substrate ofInferred only8 paths8 endpoints
- HS6ST3ProteinUNIPROT:Q8IZP7substrate ofInferred only7 paths7 endpoints
- CHST7ProteinUNIPROT:Q9NS84substrate ofInferred only7 paths7 endpoints
- NDST3ProteinUNIPROT:O95803substrate ofInferred only7 paths7 endpoints
- USTProteinUNIPROT:Q9Y2C2substrate ofInferred only6 paths6 endpoints
- HS2ST1ProteinUNIPROT:Q7LGA3substrate ofInferred only5 paths5 endpoints
What the reference databases state
Statements
79 statements
79 statements · 2 reference databases · Subject: 3,3'-diiodo-L-thyronine · Sources: Human-GEM, Rhea
- 3,3'-diiodo-L-thyronine is converted to 3,3'-diiodo-L-thyronine sulfateCompoundRhea RHEA:67892Inferred only
- 3,3'-diiodo-L-thyronine is converted to 3,3'-diiodo-L-thyronine sulfateCompoundHuman-GEM MAR06829Inferred only
- 3,3'-diiodo-L-thyronine is metabolised by SULT1A1ProteinRhea RHEA:67892Inferred only
- 3,3'-diiodo-L-thyronine is metabolised by SULT1A3ProteinRhea RHEA:67892Inferred only
- 3,3'-diiodo-L-thyronine is metabolised by SULT1A4ProteinRhea RHEA:67892Inferred only
- 3,3'-diiodo-L-thyronine is metabolised by SULT1B1ProteinRhea RHEA:67892Inferred only
- 3,3'-diiodo-L-thyronine is metabolised by SULT1B1ProteinHuman-GEM MAR06829Inferred only
- 3,3'-diiodo-L-thyronine is metabolised by SULT1C2ProteinHuman-GEM MAR06829Inferred only
- 3,3'-diiodo-L-thyronine is metabolised by SULT1C4ProteinHuman-GEM MAR06829Inferred only
- 3,3'-diiodo-L-thyronine is metabolised by SULT4A1ProteinHuman-GEM MAR06829Inferred only
- 3,3'-diiodo-L-thyronine is metabolised by UGT1A1ProteinHuman-GEM MAR06828Inferred only
- 3,3'-diiodo-L-thyronine is metabolised by UGT1A1ProteinHuman-GEM MAR06830Inferred only
Show the remaining 67
- 3,3'-diiodo-L-thyronine is metabolised by UGT1A10ProteinHuman-GEM MAR06830Inferred only
- 3,3'-diiodo-L-thyronine is metabolised by UGT1A10ProteinHuman-GEM MAR06828Inferred only
- 3,3'-diiodo-L-thyronine is metabolised by UGT1A3ProteinHuman-GEM MAR06828Inferred only
- 3,3'-diiodo-L-thyronine is metabolised by UGT1A3ProteinHuman-GEM MAR06830Inferred only
- 3,3'-diiodo-L-thyronine is metabolised by UGT1A4ProteinHuman-GEM MAR06830Inferred only
- 3,3'-diiodo-L-thyronine is metabolised by UGT1A4ProteinHuman-GEM MAR06828Inferred only
- 3,3'-diiodo-L-thyronine is metabolised by UGT1A5ProteinHuman-GEM MAR06828Inferred only
- 3,3'-diiodo-L-thyronine is metabolised by UGT1A5ProteinHuman-GEM MAR06830Inferred only
- 3,3'-diiodo-L-thyronine is metabolised by UGT1A6ProteinHuman-GEM MAR06830Inferred only
- 3,3'-diiodo-L-thyronine is metabolised by UGT1A6ProteinHuman-GEM MAR06828Inferred only
- 3,3'-diiodo-L-thyronine is metabolised by UGT1A7ProteinHuman-GEM MAR06830Inferred only
- 3,3'-diiodo-L-thyronine is metabolised by UGT1A7ProteinHuman-GEM MAR06828Inferred only
- 3,3'-diiodo-L-thyronine is metabolised by UGT1A8ProteinHuman-GEM MAR06828Inferred only
- 3,3'-diiodo-L-thyronine is metabolised by UGT1A8ProteinHuman-GEM MAR06830Inferred only
- 3,3'-diiodo-L-thyronine is metabolised by UGT1A9ProteinHuman-GEM MAR06830Inferred only
- 3,3'-diiodo-L-thyronine is metabolised by UGT1A9ProteinHuman-GEM MAR06828Inferred only
- 3,3'-diiodo-L-thyronine is metabolised by UGT2A1ProteinHuman-GEM MAR06828Inferred only
- 3,3'-diiodo-L-thyronine is metabolised by UGT2A1ProteinHuman-GEM MAR06830Inferred only
- 3,3'-diiodo-L-thyronine is metabolised by UGT2A3ProteinHuman-GEM MAR06828Inferred only
- 3,3'-diiodo-L-thyronine is metabolised by UGT2A3ProteinHuman-GEM MAR06830Inferred only
- 3,3'-diiodo-L-thyronine is metabolised by UGT2B10ProteinHuman-GEM MAR06830Inferred only
- 3,3'-diiodo-L-thyronine is metabolised by UGT2B10ProteinHuman-GEM MAR06828Inferred only
- 3,3'-diiodo-L-thyronine is metabolised by UGT2B11ProteinHuman-GEM MAR06830Inferred only
- 3,3'-diiodo-L-thyronine is metabolised by UGT2B11ProteinHuman-GEM MAR06828Inferred only
- 3,3'-diiodo-L-thyronine is metabolised by UGT2B15ProteinHuman-GEM MAR06830Inferred only
- 3,3'-diiodo-L-thyronine is metabolised by UGT2B15ProteinHuman-GEM MAR06828Inferred only
- 3,3'-diiodo-L-thyronine is metabolised by UGT2B17ProteinHuman-GEM MAR06830Inferred only
- 3,3'-diiodo-L-thyronine is metabolised by UGT2B17ProteinHuman-GEM MAR06828Inferred only
- 3,3'-diiodo-L-thyronine is metabolised by UGT2B28ProteinHuman-GEM MAR06830Inferred only
- 3,3'-diiodo-L-thyronine is metabolised by UGT2B28ProteinHuman-GEM MAR06828Inferred only
- 3,3'-diiodo-L-thyronine is metabolised by UGT2B4ProteinHuman-GEM MAR06828Inferred only
- 3,3'-diiodo-L-thyronine is metabolised by UGT2B4ProteinHuman-GEM MAR06830Inferred only
- 3,3'-diiodo-L-thyronine is metabolised by UGT2B7ProteinHuman-GEM MAR06828Inferred only
- 3,3'-diiodo-L-thyronine is metabolised by UGT2B7ProteinHuman-GEM MAR06830Inferred only
- 3,3'-diiodo-L-thyronine is metabolised by UGT3A1ProteinHuman-GEM MAR06830Inferred only
- 3,3'-diiodo-L-thyronine is metabolised by UGT3A1ProteinHuman-GEM MAR06828Inferred only
- 3,3'-diiodo-L-thyronine is metabolised by UGT3A2ProteinHuman-GEM MAR06830Inferred only
- 3,3'-diiodo-L-thyronine is metabolised by UGT3A2ProteinHuman-GEM MAR06828Inferred only
- 3,3'-diiodo-L-thyronine is a substrate of CHST10ProteinHuman-GEM MAR06829Inferred only
- 3,3'-diiodo-L-thyronine is a substrate of CHST7ProteinHuman-GEM MAR06829Inferred only
- 3,3'-diiodo-L-thyronine is a substrate of CHST9ProteinHuman-GEM MAR06829Inferred only
- 3,3'-diiodo-L-thyronine is a substrate of DIO1ProteinHuman-GEM MAR06835Inferred only
- 3,3'-diiodo-L-thyronine is a substrate of DIO1ProteinHuman-GEM MAR06834Inferred only
- 3,3'-diiodo-L-thyronine is a substrate of DIO1ProteinHuman-GEM MAR06827Inferred only
- 3,3'-diiodo-L-thyronine is a substrate of DIO1ProteinHuman-GEM MAR06826Inferred only
- 3,3'-diiodo-L-thyronine is a substrate of DIO1ProteinRhea RHEA:83783Inferred only
- 3,3'-diiodo-L-thyronine is a substrate of DIO2ProteinHuman-GEM MAR06827Inferred only
- 3,3'-diiodo-L-thyronine is a substrate of DIO2ProteinHuman-GEM MAR06835Inferred only
- 3,3'-diiodo-L-thyronine is a substrate of DIO2ProteinHuman-GEM MAR06834Inferred only
- 3,3'-diiodo-L-thyronine is a substrate of DIO2ProteinHuman-GEM MAR06826Inferred only
- 3,3'-diiodo-L-thyronine is a substrate of DIO3ProteinHuman-GEM MAR06826Inferred only
- 3,3'-diiodo-L-thyronine is a substrate of DIO3ProteinRhea RHEA:83779Inferred only
- 3,3'-diiodo-L-thyronine is a substrate of DIO3ProteinHuman-GEM MAR06827Inferred only
- 3,3'-diiodo-L-thyronine is a substrate of GAL3ST2ProteinHuman-GEM MAR06829Inferred only
- 3,3'-diiodo-L-thyronine is a substrate of GAL3ST4ProteinHuman-GEM MAR06829Inferred only
- 3,3'-diiodo-L-thyronine is a substrate of HS2ST1ProteinHuman-GEM MAR06829Inferred only
- 3,3'-diiodo-L-thyronine is a substrate of HS6ST3ProteinHuman-GEM MAR06829Inferred only
- 3,3'-diiodo-L-thyronine is a substrate of NDST1ProteinHuman-GEM MAR06829Inferred only
- 3,3'-diiodo-L-thyronine is a substrate of NDST3ProteinHuman-GEM MAR06829Inferred only
- 3,3'-diiodo-L-thyronine is a substrate of STSProteinHuman-GEM MAR02536Inferred only
- 3,3'-diiodo-L-thyronine is a substrate of STSProteinHuman-GEM MAR02538Inferred only
- 3,3'-diiodo-L-thyronine is a substrate of USTProteinHuman-GEM MAR06829Inferred only
- 3,3'-diiodo-L-thyronine is transported by SLC16A2ProteinRhea RHEA:71823Inferred only
- 3,3'-diiodo-L-thyronine is transported by SLC43A1ProteinRhea RHEA:71823Inferred only
- 3,3'-diiodo-L-thyronine is transported by SLC43A2ProteinRhea RHEA:71823Inferred only
- 3,3'-diiodo-L-thyronine is transported by SLC7A5ProteinRhea RHEA:71823Inferred only
- 3,3'-diiodo-L-thyronine is transported by SLC7A8ProteinRhea RHEA:71823Inferred only
Reactions
17 reactions
3,3'-diiodo-L-thyronine sulfate+water3,3'-diiodo-L-thyronine+proton+sulfate
Catalysed by STS
Reaction pageReversibleBalancedEC 3.1.6.2Golgi apparatus
Human-GEM MAR02536CC BY 4.0Reference data
3,3'-diiodo-L-thyronine sulfate+water3,3'-diiodo-L-thyronine+proton+sulfate
Catalysed by STS
Reaction pageReversibleBalancedEC 3.1.6.2endoplasmic reticulum
Human-GEM MAR02538CC BY 4.0Reference data
3,3'-diiodo-L-thyronine+iodide+NADP(3-)NADPH(4-)+3,3',5-triiodo-L-thyronine
Catalysed by DIO3 or DIO2 or DIO1
Reaction pageReversibleBalancedEC 1.21.99.4, 1.21.99.3cytosol
Human-GEM MAR06826CC BY 4.0Reference data
3,3'-diiodo-L-thyronine+iodide+NADP(3-)NADPH(4-)+3,3',5-triiodo-L-thyronine
Catalysed by DIO3 or DIO2 or DIO1
Reaction pageReversibleBalancedEC 1.21.99.4, 1.21.99.3endoplasmic reticulum
Human-GEM MAR06827CC BY 4.0Reference data
3,3'-diiodo-L-thyronine+UDP-alpha-D-glucuronateMAM00722c+proton+UDP
Catalysed by UGT2B10 or UGT2A3 or UGT2B28 or UGT3A1 or UGT2B4 or UGT1A6 or UGT3A2 or UGT2B7 or UGT2A1 or UGT2B15 or UGT2B17 or UGT2B11 and 8 more alternatives
Reaction pageLeft to rightBalancedEC 2.4.1.17cytosol
Human-GEM MAR06828CC BY 4.0Reference data
3,3'-diiodo-L-thyronine+3'-phospho-5'-adenylyl sulfate3,3'-diiodo-L-thyronine sulfate+proton+adenosine 3',5'-bismonophosphate
Catalysed by NDST1 or UST or CHST10 or SULT4A1 or CHST7 or HS2ST1 or CHST9 or GAL3ST2 or NDST3 or SULT1B1 or HS6ST3 or GAL3ST4 and 2 more alternatives
Reaction pageLeft to rightBalancedEC 2.8.2.-cytosol
Human-GEM MAR06829CC BY 4.0Reference data
3,3'-diiodo-L-thyronine+UDP-alpha-D-glucuronateMAM00722r+proton+UDP
Catalysed by UGT2B10 or UGT2A3 or UGT2B28 or UGT3A1 or UGT2B4 or UGT1A6 or UGT3A2 or UGT2B7 or UGT2A1 or UGT2B15 or UGT2B17 or UGT2B11 and 8 more alternatives
Reaction pageLeft to rightBalancedEC 2.4.1.17endoplasmic reticulum
Human-GEM MAR06830CC BY 4.0Reference data
3,3'-diiodo-L-thyronine sulfate+water3,3'-diiodo-L-thyronine+proton+sulfate
Catalysed by STS
Reaction pageLeft to rightBalancedEC 3.1.6.2cytosol
Human-GEM MAR06831CC BY 4.0Reference data
3,3'-diiodo-L-thyronine+iodide+NADP(3-)NADPH(4-)+MAM02839c
Reaction pageReversibleBalancedEC 1.21.99.4cytosol
Human-GEM MAR06834CC BY 4.0Reference data
3,3'-diiodo-L-thyronine+iodide+NADP(3-)NADPH(4-)+MAM02839r
Reaction pageReversibleBalancedEC 1.21.99.4endoplasmic reticulum
Human-GEM MAR06835CC BY 4.0Reference data
3,3'-diiodo-L-thyronine+3'-phosphoadenylyl sulfate3,3'-diiodo-L-thyronine sulfate+adenosine 3',5'-bisphosphate+hydron
Catalysed by SULT1B1 or SULT1A3 or SULT1A4 or SULT1A1
Reaction pageLeft to rightBalanced
Rhea RHEA:67892CC BY 4.0Reference data
3,3'-diiodo-L-thyronine+an aromatic L-alpha-amino acid3,3'-diiodo-L-thyronine+an aromatic L-alpha-amino acid
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:71427CC BY 4.0Reference data
On the label
Labelled products
1 product
Source: NIH DSLD · Ingredient: 3,3'-diiodo-L-thyronine · 1 product · Declared amount per serving: 25–25 mcg (1 products)
1 label states an amount0 do not
- Giant SportsThyroTwin25 mcgper 1 Capsule(s)DSLD:37844
Label record: NIH Office of Dietary Supplements · CC0
Where it reaches
10 systems, 23 regions, 52 tissues, 72 transporter routes — routes, not measurements: transporters known to carry 3,3'-diiodo-L-thyronine are expressed there, and no source reports it arriving.
Loading the model…