Compound
leukotriene F4
A leukotriene anion obtained by deprotonation of the three carboxy groups and protonation of the glutamyl α-amino group of leukotriene F4; major species at pH 7.3.
Definition from ChEBI (CHEBI:133618), read 2026-09-23. CC BY 4.0.
Structure
No three-dimensional record for this entry.
- Class
- Organic compound, anion
- Formula
- C28H42N2O8S
- Mass
- 566.717 g/mol
- Charge
- -2
- InChIKey
- PYSODLWHFWCFLV-VJBFNVCUSA-L
- SMILES
- CCCCC/C=CC/C=CC=CC=C[C@@H](SC[C@H](NC(=O)CC[C@H]([NH3+])C(=O)[O-])C(=O)[O-])[C@@H](O)CCCC(=O)[O-]
- Look it up
- ChEBIBy InChIKey
Identity from ChEBI. Not evidence.
What it touches on the way
Mechanistic reach
2 entities
2 entities reached.
0 reported hops2 assembled from the scaffold
What the reference databases state
Statements
7 statements
7 statements · 2 reference databases · Subject: leukotriene F4 · Sources: Human-GEM, Rhea
- leukotriene F4 is converted to CHEBI:15650CompoundHuman-GEM MAR08549Inferred only
- CHEBI:15650 is converted to leukotriene F4CompoundHuman-GEM MAR08549Inferred only
- leukotriene F4 is a substrate of CPA1ProteinRhea RHEA:50740Inferred only
- leukotriene F4 is transported by SLC22A10ProteinHuman-GEM MAR06256Inferred only
- leukotriene F4 is transported by SLCO1B1ProteinHuman-GEM MAR06157Inferred only
- leukotriene F4 is transported by SLCO1B1ProteinHuman-GEM MAR06158Inferred only
- leukotriene F4 is transported by SLCO1B1ProteinHuman-GEM MAR06159Inferred only
Reactions
9 reactions
MAM01980c+hydrogencarbonate+leukotriene F4MAM01980e+hydrogencarbonate+leukotriene F4
Transported by SLCO1B1
Reaction pageReversibleBalance undeterminableGO:0005829, GO:0005615
Human-GEM MAR06157CC BY 4.0Reference data
hydrogencarbonate+leukotriene F4+2,4-dinitrophenyl-S-glutathionehydrogencarbonate+leukotriene F4+2,4-dinitrophenyl-S-glutathione
Transported by SLCO1B1
Reaction pageReversibleBalancedGO:0005829, GO:0005615
Human-GEM MAR06158CC BY 4.0Reference data
hydrogencarbonate+leukotriene F4+MAM02901chydrogencarbonate+leukotriene F4+MAM02901e
Transported by SLCO1B1
Reaction pageReversibleBalancedGO:0005829, GO:0005615
Human-GEM MAR06159CC BY 4.0Reference data
CHEBI:16856+hydrogencarbonate+leukotriene F4CHEBI:16856+hydrogencarbonate+leukotriene F4
Reaction pageReversibleBalancedGO:0005829, GO:0005615
Human-GEM MAR06223CC BY 4.0Reference data
Transported by SLC22A10
Reaction pageReversibleBalancedGO:0005829, GO:0005615
Human-GEM MAR06256CC BY 4.0Reference data
water+leukotriene C4glycine+leukotriene F4
Reaction pageReversibleBalancedGO:0005829
Human-GEM MAR08547CC BY 4.0Reference data
water+leukotriene F4L-glutamate(1-)+CHEBI:15650
Reaction pageReversibleBalancedGO:0005829
Human-GEM MAR08549CC BY 4.0Reference data
Reaction pageReversibleBalance undeterminableGO:0005615
Human-GEM MAR09163CC BY 4.0Reference data
leukotriene C4+waterleukotriene F4+glycine
Catalysed by CPA1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:50740CC BY 4.0Reference data
Where it reaches
1 system, 1 region, 2 tissues, 2 transporter routes — routes, not measurements: transporters known to carry leukotriene F4 are expressed there, and no source reports it arriving.
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Other names
3 names
Resolves to: leukotriene F4
- Also called
- LTF4(2-)LTF4(2−)
- Systematic name
- (5S,6R,7E,9E,11Z,14Z)-6-{[(2R)-2-{[(4S)-4-azaniumyl-4-carboxylatobutanoyl]amino}-2-carboxylatoethyl]sulfanyl}-5-hydroxyicosa-7,9,11,14-tetraenoate