Endpoint
CD4+ T cell count
CAT:outcome/cd4-t-cell-countreported in cells/uL
Method
Absolute count of CD4-positive T lymphocytes per unit volume of peripheral blood by flow cytometry.
The method is part of the endpoint identity. Studies measuring the same quantity by a different method are held as separate endpoints.
Notes
SIGN INVERSION HAZARD against the CD8+ T cell count from the same cytometry tube: in this literature the CD4+ count improves by RISING (SMD +1.03) while the CD8+ count improves by FALLING (SMD -0.70), so a generic T cell count edge inverts one of the two. Also distinct from CD4+ percentage of lymphocytes and from the CD4/CD8 ratio -- an absolute count and a proportion diverge whenever the total lymphocyte pool moves.
Findings
1 finding from 1 compound, strongest first.
L-arginine — increases
LikelyGrade B, Likely. Human evidence, limited replication or design limits.Finding“With regards to cellular immunity, the arginine group exhibited a substantial increase in the CD4+ T cell count (SMD = 1.03, 95% CI: 0.67-1.38) compared to the control group.”
Quoted verbatim from Arginine on immune function and post-operative obstructions in colorectal cancer patients: a meta-analysis.. - Study
- meta-analysis
- Population
- colorectal cancer patients undergoing surgery; overall pooled estimate
Arginine on immune function and post-operative obstructions in colorectal cancer patients: a meta-analysis.2024PMID:39223466