Compound
histamine
An amine derived by enzymatic decarboxylation of histidine. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.
Structure
No depiction stored
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- Class
- Organic compound, cation
- Formula
- C5H10N3
- Mass
- 112.156 g/mol
- Charge
- +1
- InChIKey
- NTYJJOPFIAHURM-UHFFFAOYSA-O
- SMILES
- [NH3+]CCc1cncn1
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
13 entities
13 entities reached.
0 reported hops13 assembled from the scaffold
- HNMTProteinUNIPROT:P50135substrate ofInferred only33 paths11 endpoints
- TGM2ProteinUNIPROT:P21980substrate ofInferred only28 paths24 endpoints
- AOC1ProteinUNIPROT:P19801substrate ofInferred only24 paths12 endpoints
- SLC18A2ProteinUNIPROT:Q05940transported byInferred only21 paths7 endpoints
- SLCO1B3ProteinUNIPROT:Q9NPD5transported byInferred only12 paths2 endpoints
- SLC18A1ProteinUNIPROT:P54219transported byInferred only12 paths6 endpoints
- SLC22A2ProteinUNIPROT:O15244transported byInferred only10 paths5 endpoints
- SLC22A3ProteinUNIPROT:O75751transported byInferred only8 paths4 endpoints
- HDCProteinUNIPROT:P19113substrate ofInferred only6 paths6 endpoints
- SLC22A1ProteinUNIPROT:O15245transported byInferred only6 paths3 endpoints
- AOC3ProteinUNIPROT:Q16853substrate ofInferred only5 paths5 endpoints
- AOC2ProteinUNIPROT:O75106substrate ofInferred only3 paths3 endpoints
Show the remaining 1
What the reference databases state
Statements
38 statements
38 statements · 2 reference databases · Subject: histamine · Sources: Human-GEM, Rhea
- CHEBI:15971 is converted to histamineCompoundHuman-GEM MAR04428Inferred only
- histamine is converted to imidazole-4-acetaldehydeCompoundHuman-GEM MAR08783Inferred only
- histamine is converted to imidazole-4-acetaldehydeCompoundRhea RHEA:25625Inferred only
- L-histidine is converted to histamineCompoundRhea RHEA:20840Inferred only
- histamine is converted to L-histidineCompoundRhea RHEA:20840Inferred only
- histamine is converted to N(tau)-methylhistamineCompoundRhea RHEA:19301Inferred only
- histamine is converted to N(tau)-methylhistamineCompoundHuman-GEM MAR11777Inferred only
- histamine is converted to N(tau)-methylhistamineCompoundHuman-GEM MAR04429Inferred only
- N(tau)-methylhistamine is converted to histamineCompoundRhea RHEA:19301Inferred only
- histamine is a substrate of AOC1ProteinRhea RHEA:25625Inferred only
- histamine is a substrate of AOC1ProteinHuman-GEM MAR08783Inferred only
- histamine is a substrate of AOC2ProteinHuman-GEM MAR08783Inferred only
Show the remaining 26
- histamine is a substrate of AOC3ProteinHuman-GEM MAR08783Inferred only
- histamine is a substrate of HDCProteinRhea RHEA:20840Inferred only
- histamine is a substrate of HNMTProteinHuman-GEM MAR04429Inferred only
- histamine is a substrate of HNMTProteinHuman-GEM MAR11777Inferred only
- histamine is a substrate of HNMTProteinRhea RHEA:19301Inferred only
- histamine is a substrate of TGM2ProteinRhea RHEA:66564Inferred only
- histamine is transported by SLC18A1ProteinHuman-GEM MAR01442Inferred only
- histamine is transported by SLC18A1ProteinHuman-GEM MAR07633Inferred only
- histamine is transported by SLC18A2ProteinHuman-GEM MAR07633Inferred only
- histamine is transported by SLC18A2ProteinHuman-GEM MAR01442Inferred only
- histamine is transported by SLC18A2ProteinRhea RHEA:73755Inferred only
- histamine is transported by SLC22A1ProteinHuman-GEM MAR04999Inferred only
- histamine is transported by SLC22A1ProteinRhea RHEA:73879Inferred only
- histamine is transported by SLC22A2ProteinHuman-GEM MAR04999Inferred only
- histamine is transported by SLC22A2ProteinRhea RHEA:73879Inferred only
- histamine is transported by SLC22A3ProteinRhea RHEA:73879Inferred only
- histamine is transported by SLC22A3ProteinHuman-GEM MAR04999Inferred only
- histamine is transported by SLC29A4ProteinRhea RHEA:73879Inferred only
- histamine is transported by SLCO1A2ProteinHuman-GEM MAR04436Inferred only
- histamine is transported by SLCO1A2ProteinHuman-GEM MAR04434Inferred only
- histamine is transported by SLCO1A2ProteinHuman-GEM MAR04435Inferred only
- histamine is transported by SLCO1A2ProteinHuman-GEM MAR04433Inferred only
- histamine is transported by SLCO1B3ProteinHuman-GEM MAR04436Inferred only
- histamine is transported by SLCO1B3ProteinHuman-GEM MAR04435Inferred only
- histamine is transported by SLCO1B3ProteinHuman-GEM MAR04434Inferred only
- histamine is transported by SLCO1B3ProteinHuman-GEM MAR04433Inferred only
Reactions
22 reactions
Reaction pageReversibleBalance undeterminableextracellular space
Human-GEM MAR00619CC BY 4.0Reference data
ATP+water+histamineADP+proton+histamine+phosphate(3-)
Transported by SLC18A1 or SLC18A2
Reaction pageLeft to rightBalancedEC 2.7.1.1cytosol, extracellular space
Human-GEM MAR01442CC BY 4.0Reference data
proton+CHEBI:15971carbon dioxide+histamine
Catalysed by HDC
Reaction pageLeft to rightBalancedEC 4.1.1.22, 4.1.1.28cytosol
Human-GEM MAR04428CC BY 4.0Reference data
histamine+S-adenosyl-L-methionineproton+N(tau)-methylhistamine+CHEBI:16680
Catalysed by HNMT
Reaction pageLeft to rightBalancedEC 2.1.1.8cytosol
Human-GEM MAR04429CC BY 4.0Reference data
MAM01980c+hydrogencarbonate+histamineMAM01980e+hydrogencarbonate+histamine
Transported by SLCO1A2 & SLCO1B3
Reaction pageReversibleBalance undeterminablecytosol, extracellular space
Human-GEM MAR04433CC BY 4.0Reference data
hydrogencarbonate+histamine+2,4-dinitrophenyl-S-glutathionehydrogencarbonate+histamine+2,4-dinitrophenyl-S-glutathione
Transported by SLCO1A2 & SLCO1B3
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR04434CC BY 4.0Reference data
hydrogencarbonate+histamine+MAM02901chydrogencarbonate+histamine+MAM02901e
Transported by SLCO1A2 & SLCO1B3
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR04435CC BY 4.0Reference data
CHEBI:16856+hydrogencarbonate+histamineCHEBI:16856+hydrogencarbonate+histamine
Transported by SLCO1A2 & SLCO1B3
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR04436CC BY 4.0Reference data
Transported by SLC22A2 or SLC22A3 or SLC22A1
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR04999CC BY 4.0Reference data
2ATP+2water+3histamine2ADP+2proton+3histamine+2phosphate(3-)
Transported by SLC18A1 or SLC18A2
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR07633CC BY 4.0Reference data
water+histamine+dioxygenproton+hydrogen peroxide+imidazole-4-acetaldehyde+ammonium
Catalysed by AOC1 or AOC3 or AOC2
Reaction pageLeft to rightBalancedEC 1.4.3.21, 1.4.3.22cytosol
Human-GEM MAR08783CC BY 4.0Reference data
histamine+S-adenosyl-L-methionineproton+N(tau)-methylhistamine+CHEBI:16680
Catalysed by HNMT
Reaction pageLeft to rightBalancedextracellular space
Human-GEM MAR11777CC BY 4.0Reference data
Where it reaches
6 systems, 9 regions, 16 tissues, 19 transporter routes — routes, not measurements: transporters known to carry histamine are expressed there, and no source reports it arriving.
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Other names
2 names
Resolves to: histamine
- Also called
- histaminium cation
- Systematic name
- 2-(1H-imidazol-4-yl)ethanaminium