Compound
orotic acid
An intermediate product in pyrimidine synthesis which plays a role in chemical conversions between dihydrofolate and tetrahydrofolate.
What it touches on the way
Mechanistic reach
3 entities
3 entities reached.
What the reference databases state
Chemical structure
- orotic acid has the functional parent uracilCompoundChEBI CHEBI:16742Inferred only
Statements
5 statements
5 statements · 1 reference database · Subject: orotic acid · Sources: Human-GEM
- orotic acid is converted to (S)-dihydroorotateCompoundHuman-GEM MAR04575Inferred only
- (S)-dihydroorotate is converted to orotic acidCompoundHuman-GEM MAR04575Inferred only
- orotic acid is a substrate of DHODHProteinHuman-GEM MAR04575Inferred only
- orotic acid is a substrate of UMPSProteinHuman-GEM MAR04577Inferred only
- orotic acid is transported by SLC22A7ProteinHuman-GEM MAR09031Inferred only
Reactions
6 reactions
(S)-dihydroorotate+CHEBI:17621orotic acid+FMNH2
Catalysed by DHODH
Reaction pageReversibleBalancedEC 1.3.5.2, 1.3.1.14GO:0005829
Human-GEM MAR04575CC BY 4.0Reference data
orotic acid+5-phospho-alpha-D-ribose 1-diphosphateCHEBI:15842+diphosphate(3-)
Catalysed by UMPS
Reaction pageLeft to rightBalancedEC 2.4.2.10GO:0005829
Human-GEM MAR04577CC BY 4.0Reference data
Reaction pageReversibleBalancedGO:0005829, GO:0005615
Human-GEM MAR04875CC BY 4.0Reference data
L-glutamate(1-)+orotic acidL-glutamate(1-)+orotic acid
Transported by SLC22A7
Reaction pageReversibleBalancedEC 3.1.1.31GO:0005829, GO:0005615
Human-GEM MAR09031CC BY 4.0Reference data
Reaction pageReversibleBalance undeterminableGO:0005615
Human-GEM MAR09690CC BY 4.0Reference data
proton+orotic acidproton+orotic acid
Reaction pageLeft to rightBalancedGO:0005615, GO:0005829
Human-GEM MAR11315CC BY 4.0Reference data
Where it reaches
1 system, 1 region, 2 tissues, 2 transporter routes — routes, not measurements: transporters known to carry orotic acid are expressed there, and no source reports it arriving.
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Other names
2 names
Resolves to: orotic acid
- Also called
- Uracil-6-carboxylic acid
- Systematic name
- 2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid