Endpoint
Serum uric acid
An oxidation product, via xanthine oxidase, of oxypurines such as xanthine and hypoxanthine. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals urate oxidase further oxidizes it to allantoin.
CAT:outcome/serum-uric-acidreported in mg/dL3 findings from 3 compounds
What moved it
How to read these marks3 findings · 3 compounds · 1 null · by evidence strength
| Compound | Direction | Findings | Strongest evidence |
|---|---|---|---|
| melatonin | up | 1 | Evidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence. |
| resveratrol | no effect | 1 | Evidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence. |
| astaxanthin | down | 1 | Evidence strength: insufficient. Mechanistic inference, no evidence found, or evidence weakened below very limited. |
Reported to move it
2 findings
melatonin — increases
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“Levels of reduced glutathione, total bilirubin, and uric acid increased in TMG comparatively with TPG (all: p < 0.001) and MG (p = 0.002; p = 0.0002; p < 0.001, respectively).”
Quoted verbatim from Benefits of 12-week self-paced training combined with melatonin supplementation on oxidative stress, inflammation, hyperlipidemia, and body composition in multiple sclerosis patients: A randomized controlled trial.. - Study
- RCT
- Duration
- 3 months
- Dose
- 3 mg/night
- Population
- patients with multiple sclerosis (PwMS); training + melatonin (TMG) vs training + placebo (TPG), both arms also received concurrent aerobic-resistance training
Benefits of 12-week self-paced training combined with melatonin supplementation on oxidative stress, inflammation, hyperlipidemia, and body composition in multiple sclerosis patients: A randomized controlled trial.2026PMID:42217742Permalink
astaxanthin — decreases
InsufficientEvidence strength: insufficient. Mechanistic inference, no evidence found, or evidence weakened below very limited.Finding“Also, AST significantly reduced the amount of creatinine, urea, and uric acid in the serum and improved the activity of SOD and catalase in the kidney tissue (p < 0.05).”
Quoted verbatim from Astaxanthin prevents nephrotoxicity through Nrf2/HO-1 pathway.. - Study
- animal · not in humans
- Duration
- 10 days
- Dose
- 25, 50, or 75 mg/kg astaxanthin during the 10-day course, alongside MTX 10 mg/kg on days 6, 8, 10
- Population
- male Wistar rats with methotrexate-induced nephrotoxicity
Astaxanthin prevents nephrotoxicity through Nrf2/HO-1 pathway.2024PMID:37683291Permalink
Measured, no effect detected
1 finding
resveratrol — no detected effect on
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.FindingNull result“However, the circulating values of albumin and uric acid were not affected by resveratrol supplementation.”
Quoted verbatim from Effects of resveratrol supplementation on renal function in adults: a systematic review and dose-response meta-analysis.. - Study
- meta-analysis
- Population
- Adults; pooled meta-analysis of RCTs of resveratrol supplementation on renal function outcomes (31 studies).
Effects of resveratrol supplementation on renal function in adults: a systematic review and dose-response meta-analysis.2025PMID:40580309Permalink
How it is measured
Serum or plasma uric acid concentration by clinical uricase enzymatic assay.
Measured, not recorded
- Subject
- serum uric acid
- Measurements
- 12 measurements
- Recorded as a finding
- No
Show what was measured
serum uric acid
decreases, reduced (p < 0.05)
Also, AST significantly reduced the amount of creatinine, urea, and uric acid in the serum and improved the activity of SOD and catalase in the kidney tissue (p < 0.05).
PMID:37683291 · both readings recorded this
Serum uric acid
decreases, 4.90±0.22
Notably, cholesterol (49.00±6.48), triglycerides (47.25±2.22), LDL (34.50±3.11), uric acid (4.90±0.22), urea (46.00±0.82), creatinine (0.35±0.03), blood glucose (193.00±11.20), and weight gain (77.75±2.06) were lower.
PMID:40292062 · both readings recorded this
serum uric acid
Not recorded as a finding: one-sided negation in a list sentence ('but not'); no two-sided statement of no difference and no estimate, so no_effect is not recordable
Riboflavin supplementation significantly decreased plasma tHcy (P=0.005) and EGRAC (P=0.014), but not plasma ferritin, uric acid or C-reactive protein.
PMID:19390751 · one of two readings recorded this
serum uric acid
decreases
Not recorded as a finding: sentence refers back with 'these results are associated with' rather than independently naming curcumin; not self-supporting as a standalone quote
These results are associated with reduced levels of homeostasis model assessment-insulin resistance, triglyceride, uric acid, visceral fat and total body fat.
PMID:24445038 · one of two readings recorded this
serum uric acid
decreases, p = 0.001, n = 103
Increasing sodium intake from the low level decreased serum UA during the medium sodium intake period (-0.3 mg/dl [95% CI -0.5, -0.2], P < 0.001)
PMID:27523583 · one of two readings recorded this
serum uric acid
decreases, n = 8
with a higher effect (-1.29 mg/dl [95% CI -2.50, -0.08]) among participants (n = 8) with a baseline serum UA level of ≥7 mg/dl
PMID:27523583 · one of two readings recorded this
serum uric acid
decreases, p = 0.001, n = 103
and during the high sodium intake period (-0.4 mg/dl [95% CI -0.6, -0.3], P < 0.001)
PMID:27523583 · one of two readings recorded this
serum uric acid
decreases, p = 0.02, n = 103
The DASH diet reduced serum UA (-0.35 mg/dl [95% confidence interval (95% CI) -0.65, -0.05], P = 0.02)
PMID:27523583 · one of two readings recorded this
serum uric acid
decreases, p = 0.001, n = 103
increasing sodium intake (from low to high) lowered serum uric acid (−0.4 mg/dL; P < 0.001)
PMID:27938853 · one of two readings recorded this
serum uric acid
no effect, p = 0.925, n = 18
The main effect of the solution was not significant (F (2, 17) = 0.08, p = 0.925)
PMID:36678329 · one of two readings recorded this
serum uric acid
modulates, p = 0.001, n = 18
The solution-by-time interaction effect was significant (F (6, 35) = 9.91, p = 0.001)
PMID:36678329 · one of two readings recorded this
serum uric acid
no effect, n = 18
D-allulose and erythritol had no effect on uric acid compared to tap water
PMID:36678329 · one of two readings recorded this
Sources cited
3 papers
- Subject
- serum uric acid
- Findings
- 3
- Papers
- 3
Benefits of 12-week self-paced training combined with melatonin supplementation on oxidative stress, inflammation, hyperlipidemia, and body composition in multiple sclerosis patients: A randomized controlled trial.record2026PMID:422177421 finding
Effects of resveratrol supplementation on renal function in adults: a systematic review and dose-response meta-analysis.record2025PMID:405803091 finding
Astaxanthin prevents nephrotoxicity through Nrf2/HO-1 pathway.record2024PMID:376832911 finding