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Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

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Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Interactions

Documented interactions:: none reported
Unlisted pair:: unknown, not ruled safe

pairs: 26
compounds involved: 18
proteins shared by the top pair: 19

Pairs by number of shared proteins

10 or more proteins6
3 to 9 proteins10
1 or 2 proteins10

Most shared proteins

L-leucine and L-glutamine19 proteins
L-leucine and L-valine16 proteins
L-valine and L-isoleucine16 proteins

Inferred

All pairs are hypotheses, not documented.

Pairs sharing a protein

26 pairs

26 pairs · 18 studied compounds · Reported route: 0 · Assembled route: 26

L-leucine and L-glutamine19 shared proteinsHypothesis
L-leucine and L-valine16 shared proteinsHypothesis
L-valine and L-isoleucine16 shared proteinsHypothesis
L-leucine and L-isoleucine16 shared proteinsHypothesis
L-valine and L-glutamine13 shared proteinsHypothesis
L-isoleucine and L-glutamine12 shared proteinsHypothesis
L-leucine and L-arginine9 shared proteinsHypothesis
L-arginine and L-glutamine8 shared proteinsHypothesis
L-valine and L-arginine8 shared proteinsHypothesis
L-arginine and L-isoleucine8 shared proteinsHypothesis
L-citrulline and L-arginine5 shared proteinsHypothesis
L-leucine and L-citrulline4 shared proteinsHypothesis

Show the remaining 14

L-citrulline and L-valine4 shared proteinsHypothesis
L-citrulline and L-isoleucine4 shared proteinsHypothesis
L-citrulline and L-glutamine4 shared proteinsHypothesis
melatonin and all-cis-docosa-4,7,10,13,16,19-hexaenoic acid3 shared proteinsHypothesis
nitrate and L-glutamine2 shared proteinsHypothesis
magnesium(2+) and iron(2+)2 shared proteinsHypothesis
berberine and (-)-epigallocatechin 3-gallate1 shared proteinHypothesis
L-isoleucine and coenzyme Q101 shared proteinHypothesis
L-isoleucine and resveratrol1 shared proteinHypothesis
resveratrol and coenzyme Q101 shared proteinHypothesis
L-valine and nitrate1 shared proteinHypothesis
nitrate and magnesium(2+)1 shared proteinHypothesis
zeaxanthin and lutein1 shared proteinHypothesis
all-cis-docosa-4,7,10,13,16,19-hexaenoic acid and chondroitin sulfate1 shared proteinHypothesis

Scope: compounds studied as interventions · Source: open reaction databases (partial coverage)