knowcompoundshuperzine A
Specimen compound organic compoundPlate I
Huperzine A
- Formula
- C15H18N2O
- Molar mass
- 242.322 g/mol
- ChEBI
- CHEBI:78330
- PubChem CID
- 854026
- InChIKey
- ZRJBHWIHUMBLCN-YQEJDHNASA-N
↑ raised 1 finding · – no difference found
01 · the evidence, ordered
What the evidence says
- Very limited
Huperzine A
Most findings
- Mini-Mental State Examination total score×2
- Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-cog) score×1
8 compounds on the outer ring, not drawn
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02 · contested · 1 endpoint
Where the findings disagree
012 findings
Mini-Mental State Examination total score
03 · findings
What huperzine A moved, and by how much
- MD mean difference. Brackets: the interval as reported.
- Dose studied: as its paper gave it.
- Evidence strength: computed from the study. How it is computed
- Mini-Mental State Examination total scorecontestedMoved: raisesEvidence: Very limitedPaper: PMID 192216922009
- Who
- Patients with Alzheimer's disease; meta-analysis of four randomized trials comparing huperzine A with placebo
- Dose studied
- 300-500 microg daily, oral, 8-24 weeks
Oral administration of HupA for 8-24 weeks (300-500 microg daily) led to significant improvements in MMSE and ADL.”
Quoted verbatim from Efficacy and safety of natural acetylcholinesterase inhibitor huperzine A in the treatment of Alzheimer's disease: an updated meta-analysis.meta-analysisPermalink - Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-cog) scoreMoved: no difference foundEvidence: Very limitedPaper: PMID 215025972011
- Who
- Adults with mild to moderate Alzheimer disease; multicenter trial, huperzine A 200 μg BID against placebo
- Dose studied
- huperzine A 200 μg BID, oral
Huperzine A 200 μg BID did not influence change in ADAS-Cog at 16 weeks.”
Quoted verbatim from A phase II trial of huperzine A in mild to moderate Alzheimer disease.RCT · 4 monthsPermalink - Mini-Mental State Examination total scorecontestedMoved: no difference foundEffect, as reportedMD2.4[−4.78 to 9.58]Evidence: Very limitedPaper: PMID 193706862009
- Who
- patients with vascular dementia; the review's single included trial
- Dose studied
- not reported
No significant beneficial effect of Huperzine A on the improvement of cognitive function measured by MMSE for VaD (WMD 2.40; 95% CI -4.78 to 9.58) was observed.”
Quoted verbatim from Huperzine A for vascular dementia.RCTPermalink
No row matches these filters.
No dose is advised.
- MD mean difference. Brackets: the interval as reported.
- Dose studied: as its paper gave it.
- Evidence strength: computed from the study. How it is computed
04 · identity
Structure
- Charge
- 0
- 2D depiction
- None stored
- SMILES
- [H][C@@]12C=C(C)C[C@@](N)(/C1=C/C)c1ccc(=O)nc1C2
05 · on the label · 1,060 products
Labelled products
Source: NIH DSLD · Ingredient: huperzine A · 1,060 products · Declared amount per serving (the first 1,000 shown): 2–250,000 µg
705 labels of the first 1,000 shown state an amount295 do not
- 'Merica LabzA Bomb Red, White & Boom Alpine Pew PewHuperzine A · 1% Huperzine A10 mgper 10.7 gDSLD:271100
- 'Merica LabzA Bomb Red, White & Boom Wild Blue YonderHuperzine A · 1% Huperzine A10 mgper 21.5 gDSLD:273702
- 'Merica LabzF-Bomb Firecracker CandyHuperzine A10 mgper 8.5 gDSLD:278031
- 'Merica LabzRed White & Boom Back In Black LemonadeHuperzine A · 1% huperzine A10 mgper 10.3 gDSLD:271113
- 'Merica LabzRed White & Boom Daytona BeachHuperzine A · 1% huperzine A10 mgper 10.3 gDSLD:271640
- 'Merica LabzRed White & Boom FreedomHuperzine A10 mgper 10.4 gDSLD:271642
- 'Merica LabzRed White & Boom Fresa LimaHuperzine A · 1% huperzine A10 mgper 10.15 gDSLD:271644
- 1 BodyBrain SupportHuperzia serrata leaf standardized extract250 µgper 3 capsulesDSLD:257246
- 1st Phorm1-Db OverdriveHuperzine A · Stnd. to 1% Huperzine A2 mgper 2 capsulesDSLD:288071
- 1st PhormMegawatt Pink Lemonade50 µgper 5.5 gDSLD:312634
- 1st PhormProject-1 Candy Burst100 µgper 26.8 gDSLD:312636
- 1st PhormRoyal XXI Kingamount not statedper 1 capsuleDSLD:211507
Show the remaining 1,048Show the first 12
Label record: NIH Office of Dietary Supplements · CC0
06 · the record
Sources
31
papers screened for huperzine A
- admitted
- 5
- read and discarded
- 19
- not read yet
- 7
- Documented interactions
- None reported
Sources cited
3 papers · 3 findings
2 admitted at screening, no finding yet