Endpoint
Incidence of myocardial infarction
CAT:outcome/myocardial-infarction-incidencereported in hazard ratio1 finding from 1 compound
What moved it
How to read these marks1 finding · 1 compound · by evidence strength
| Compound | Direction | Findings | Strongest evidence |
|---|---|---|---|
| Ca(2+) | up | 1 | Evidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers. |
Reported to move it
1 finding
Ca(2+) — increases
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Finding“The meta-analysis of trial level data showed similar results: 296 people had a myocardial infarction (166 allocated to calcium, 130 to placebo), with an increased incidence of myocardial infarction in those allocated to calcium (pooled relative risk 1.27, 95% confidence interval 1.01 to 1.59, P=0.038).”
Quoted verbatim from Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta-analysis.. - Study
- meta-analysis
- Dose
- calcium supplements of at least 500 mg/day (eligibility criterion)
- Population
- Adults (mean age over 40) in randomised placebo-controlled trials of calcium supplements without coadministered vitamin D; trial-level pooled analysis
Effect 1.27 risk ratio, 95% CI 1.01 to 1.59
Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta-analysis.2010PMID:20671013Permalink
How it is measured
Adjudicated myocardial infarction events during follow-up, ascertained by an endpoint committee against a universal-definition or study-specific criterion. Whether fatal infarctions are counted, and whether silent infarctions detected on ECG are counted, recorded with each finding.
Sources cited
1 paper
- Subject
- incidence of myocardial infarction
- Findings
- 1
- Papers
- 1