Endpoint
Adverse reaction incidence (unstandardised)
CAT:outcome/adverse-reaction-incidence-ungradedreported in event rate2 findings from 2 compounds
What moved it
How to read these marks2 findings · 2 compounds · 1 null · by evidence strength
| Compound | Direction | Findings | Strongest evidence |
|---|---|---|---|
| berberine | no effect | 1 | Evidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers. |
| caffeine | down | 1 | Evidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers. |
Reported to move it
1 finding
caffeine — decreases
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Finding“The analysis found that compared with aminophylline, infants in the caffeine group had a lower chance of developing total adverse effects (OR 0.41, 95%CI: 0.17–0.97, P = 0.042).”
Quoted verbatim from Comparative efficacy and safety of caffeine citrate and aminophylline in treating apnea of prematurity: A systematic review and meta-analysis.. - Study
- meta-analysis
- Population
- Preterm infants (<37 weeks gestation) with apnea of prematurity; caffeine citrate against an ACTIVE COMPARATOR (aminophylline), not placebo; safety outcome pooled from 4 of the 10 included studies.
Effect 0.41 odds ratio, 95% CI 0.17 to 0.97
Comparative efficacy and safety of caffeine citrate and aminophylline in treating apnea of prematurity: A systematic review and meta-analysis.2022PMID:36121807Permalink
Measured, no effect detected
1 finding
berberine — no detected effect on
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“Nonetheless, the impact of BBR on reducing adverse reactions was not statistically significant (RR = 0.75, 95% CI [0.42, 1.33], P > 0.05).”
Quoted verbatim from Efficacy and safety of berberine plus 5-ASA for ulcerative colitis: A systematic review and meta-analysis.. - Study
- meta-analysis
- Population
- patients with ulcerative colitis; berberine plus 5-aminosalicylic acid versus 5-aminosalicylic acid
Efficacy and safety of berberine plus 5-ASA for ulcerative colitis: A systematic review and meta-analysis.2024PMID:39241013Permalink
How it is measured
Proportion of participants for whom investigators recorded at least one adverse reaction attributed to the study product, tallied by each trial's own ascertainment with no severity classification system applied.
Sources cited
2 papers
- Subject
- adverse reaction incidence (unstandardised)
- Findings
- 2
- Papers
- 2
Efficacy and safety of berberine plus 5-ASA for ulcerative colitis: A systematic review and meta-analysis.record2024PMID:392410131 finding
Comparative efficacy and safety of caffeine citrate and aminophylline in treating apnea of prematurity: A systematic review and meta-analysis.record2022PMID:361218071 finding