Compound
malonate
A dicarboxylic acid dianion obtained by the deprotonation of the carboxy groups of malonic acid.
Definition from ChEBI (CHEBI:15792), read 2026-09-23. CC BY 4.0.
Structure
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- Class
- Organic compound, anion
- Formula
- C3H2O4
- Mass
- 102.045 g/mol
- Charge
- -2
- InChIKey
- OFOBLEOULBTSOW-UHFFFAOYSA-L
- SMILES
- O=C([O-])CC(=O)[O-]
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
6 entities
6 entities reached.
0 reported hops6 assembled from the scaffold
- SLC25A10ProteinUNIPROT:Q9UBX3transported byInferred only180 paths45 endpoints
- UCP2ProteinUNIPROT:P55851transported byInferred only47 paths47 endpoints
- SLC25A11ProteinUNIPROT:Q02978transported byInferred only22 paths22 endpoints
- ACSF3ProteinUNIPROT:Q4G176substrate ofInferred only6 paths6 endpoints
- SLC25A30ProteinUNIPROT:Q5SVS4transported byInferred only2 paths2 endpoints
- SLC25A14ProteinUNIPROT:O95258transported byInferred only2 paths2 endpoints
What the reference databases state
Statements
19 statements
19 statements · 1 reference database · Subject: malonate · Sources: Rhea
- malonate is converted to 3-oxopropanoateCompoundRhea RHEA:20041Inferred only
- 3-oxopropanoate is converted to malonateCompoundRhea RHEA:20045Inferred only
- 3-oxopropanoate is converted to malonateCompoundRhea RHEA:20041Inferred only
- malonate is converted to 3-oxopropanoateCompoundRhea RHEA:20045Inferred only
- acetate is converted to malonateCompoundRhea RHEA:58820Inferred only
- malonate is converted to acetateCompoundRhea RHEA:25896Inferred only
- malonate is converted to acetateCompoundRhea RHEA:58820Inferred only
- acetate is converted to malonateCompoundRhea RHEA:18817Inferred only
- acetate is converted to malonateCompoundRhea RHEA:25896Inferred only
- malonate is converted to acetateCompoundRhea RHEA:18817Inferred only
- malonate is a substrate of ACSF3ProteinRhea RHEA:32139Inferred only
- malonate is transported by SLC25A10ProteinRhea RHEA:71611Inferred only
Show the remaining 7
- malonate is transported by SLC25A10ProteinRhea RHEA:73195Inferred only
- malonate is transported by SLC25A10ProteinRhea RHEA:71667Inferred only
- malonate is transported by SLC25A10ProteinRhea RHEA:71623Inferred only
- malonate is transported by SLC25A11ProteinRhea RHEA:71591Inferred only
- malonate is transported by SLC25A14ProteinRhea RHEA:73195Inferred only
- malonate is transported by SLC25A30ProteinRhea RHEA:73195Inferred only
- malonate is transported by UCP2ProteinRhea RHEA:73387Inferred only
Reactions
18 reactions
CHEBI:58775+watermalonate+urea+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:17361CC BY 4.0Reference data
acetyl-[ACP]+malonatemalonyl-[ACP]+acetate
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:17649CC BY 4.0Reference data
malonate+acetyl-CoAacetate+malonyl-CoA
Reaction pageDirection not assertedBalanced
Rhea RHEA:18817CC BY 4.0Reference data
3-oxopropanoate+NADP(3-)+watermalonate+NADPH(4-)+2hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:20041CC BY 4.0Reference data
3-oxopropanoate+NAD(1-)+watermalonate+NADH(2-)+2hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:20045CC BY 4.0Reference data
3-hydroxy-3-methylglutarate+malonyl-CoA(3S)-3-hydroxy-3-methylglutaryl-CoA+malonate
Reaction pageDirection not assertedBalanced
Rhea RHEA:24948CC BY 4.0Reference data
malonate+hydronacetate+carbon dioxide
Reaction pageDirection not assertedBalanced
Rhea RHEA:25896CC BY 4.0Reference data
malonate+ATP(4-)+coenzyme A(4-)malonyl-CoA+AMP+diphosphate(3-)
Catalysed by ACSF3
Reaction pageLeft to rightBalanced
Rhea RHEA:32139CC BY 4.0Reference data
Reaction pageDirection not assertedBalanced
Rhea RHEA:33115CC BY 4.0Reference data
malonate+sodium(1+)malonate+sodium(1+)
Reaction pageDirection not assertedBalanced
Rhea RHEA:33135CC BY 4.0Reference data
malonyl-CoA+watermalonate+coenzyme A(4-)+hydron
Catalysed by ACOT8
Reaction pageLeft to rightBalanced
Rhea RHEA:40219CC BY 4.0Reference data
malonate+sodium(1+)+hydronacetate+sodium(1+)+carbon dioxide
Reaction pageDirection not assertedBalanced
Rhea RHEA:58820CC BY 4.0Reference data
Where it reaches
10 systems, 24 regions, 92 tissues, 103 transporter routes — routes, not measurements: transporters known to carry malonate are expressed there, and no source reports it arriving.
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Other names
9 names
Resolves to: malonate
- Also called
- (-)OOC-CH2-COO(-)−OOC‒CH2‒COO−maloMALONATE IONmalonic acid, ion(2-)malonic acid, ion(2−)propanedioic acid, ion(2-)propanedioic acid, ion(2−)
- Systematic name
- propanedioate