Compound
tryptamine
An aminoalkylindole consisting of indole having a 2-aminoethyl group at the 3-position.
Definition from ChEBI (CHEBI:16765), read 2026-09-23. CC BY 4.0.
What it touches on the way
Mechanistic reach
5 entities
5 entities reached.
0 reported hops5 assembled from the scaffold
- MAOAProteinUNIPROT:P21397metabolized byInferred only36 paths36 endpoints
- MAOBProteinUNIPROT:P27338metabolized byInferred only13 paths13 endpoints
- AOC1ProteinUNIPROT:P19801substrate ofInferred only12 paths12 endpoints
- INMTProteinUNIPROT:O95050substrate ofInferred only7 paths7 endpoints
- SLC29A4ProteinUNIPROT:Q7RTT9transported byInferred only1 path1 endpoint
What the reference databases state
Chemical structure
- melatonin has the functional parent tryptamineCompoundChEBI CHEBI:16796Inferred only
Statements
8 statements
8 statements · 1 reference database · Subject: tryptamine · Sources: Human-GEM
- tryptamine is converted to indole-3-acetaldehydeCompoundHuman-GEM MAR06713Inferred only
- L-tryptophan is converted to tryptamineCompoundHuman-GEM MAR06707Inferred only
- tryptamine is converted to N-methyltryptamineCompoundHuman-GEM MAR06711Inferred only
- tryptamine is metabolised by MAOAProteinHuman-GEM MAR06713Inferred only
- tryptamine is metabolised by MAOBProteinHuman-GEM MAR06713Inferred only
- tryptamine is a substrate of AOC1ProteinHuman-GEM MAR06713Inferred only
- tryptamine is a substrate of INMTProteinHuman-GEM MAR06711Inferred only
- tryptamine is transported by SLC29A4ProteinHuman-GEM MAR11789Inferred only
Reactions
16 reactions
proton+L-tryptophancarbon dioxide+tryptamine
Catalysed by DDC
Reaction pageLeft to rightBalancedEC 4.1.1.28GO:0005829
Human-GEM MAR06707CC BY 4.0Reference data
S-adenosyl-L-methionine+tryptamineproton+N-methyltryptamine+CHEBI:16680
Catalysed by INMT
Reaction pageLeft to rightBalancedEC 2.1.1.49GO:0005829
Human-GEM MAR06711CC BY 4.0Reference data
MAM00230c+waterformaldehyde+tryptamine
Reaction pageReversibleBalancedGO:0005829
Human-GEM MAR06712CC BY 4.0Reference data
water+dioxygen+tryptamineproton+hydrogen peroxide+indole-3-acetaldehyde+ammonium
Catalysed by AOC1 or MAOB or MAOA
Reaction pageLeft to rightBalancedEC 1.4.3.4, 1.4.3.22GO:0005829
Human-GEM MAR06713CC BY 4.0Reference data
proton+tryptamineproton+tryptamine
Transported by SLC29A4
Reaction pageReversibleBalancedGO:0005829, GO:0005615
Human-GEM MAR11789CC BY 4.0Reference data
Reaction pageReversibleBalance undeterminableGO:0005615
Human-GEM MAR11923CC BY 4.0Reference data
CHEBI:58193+waterCHEBI:18002+tryptamine
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:15013CC BY 4.0Reference data
tryptamine+AH2+dioxygenCHEBI:139069+A+water
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:15865CC BY 4.0Reference data
L-tryptophan+hydrontryptamine+carbon dioxide
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:30339CC BY 4.0Reference data
tryptamine+reduced [NADPH--hemoprotein reductase]+dioxygenserotonin+oxidized [NADPH--hemoprotein reductase]+water+hydron
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:52320CC BY 4.0Reference data
tryptamine+dioxygen+waterindole-3-acetaldehyde+hydrogen peroxide+ammonium
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:59416CC BY 4.0Reference data
tryptamine+acetyl-CoACHEBI:55515+coenzyme A(4-)+hydron
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:66196CC BY 4.0Reference data
Where it reaches
1 system, 1 region, 1 tissue, 1 transporter route — routes, not measurements: transporters known to carry tryptamine are expressed there, and no source reports it arriving.
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Other names
4 names
Resolves to: tryptamine
- Also called
- 1H-indole-3-ethanamine2-(1H-INDOL-3-YL)ETHANAMINE2-(3-indolyl)ethylamine3-(2-Aminoethyl)indole