Compound
glycochenodeoxycholate
A bile salt formed in the liver from chenodeoxycholate and glycine, usually as the sodium salt. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is a cholagogue and choleretic.
Structure
Loading the model…
- Class
- Organic compound, anion
- Formula
- C26H42NO5
- Mass
- 448.624 g/mol
- Charge
- -1
- InChIKey
- GHCZAUBVMUEKKP-GYPHWSFCSA-M
- SMILES
- [H][C@@]12C[C@H](O)CC[C@]1(C)[C@@]1([H])CC[C@@]3(C)[C@@]([H])(CC[C@]3([H])[C@H](C)CCC(=O)NCC(=O)[O-])[C@]1([H])[C@H](O)C2
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
5 entities
5 entities reached.
0 reported hops5 assembled from the scaffold
- SULT2A1ProteinUNIPROT:Q06520metabolized byInferred only24 paths24 endpoints
- ABCC4ProteinUNIPROT:O15439transported byInferred only10 paths10 endpoints
- SLC51BProteinUNIPROT:Q86UW2transported byInferred only9 paths9 endpoints
- SLC51AProteinUNIPROT:Q86UW1transported byInferred only5 paths5 endpoints
- ABCB11ProteinUNIPROT:O95342transported byInferred only4 paths3 endpoints
What the reference databases state
Chemical structure
- glycochenodeoxycholate 3-sulfate has the functional parent glycochenodeoxycholateCompoundChEBI CHEBI:234533Inferred only
Statements
10 statements
10 statements · 1 reference database · Subject: glycochenodeoxycholate · Sources: Rhea
- 7-oxoglycolithocholate is converted to glycochenodeoxycholateCompoundRhea RHEA:53844Inferred only
- glycochenodeoxycholate is converted to 7-oxoglycolithocholateCompoundRhea RHEA:53844Inferred only
- 7-oxoglycolithocholate is converted to glycochenodeoxycholateCompoundRhea RHEA:65056Inferred only
- glycochenodeoxycholate is converted to glycochenodeoxycholate 3-sulfateCompoundRhea RHEA:85747Inferred only
- glycochenodeoxycholate is metabolised by SULT2A1ProteinRhea RHEA:85747Inferred only
- glycochenodeoxycholate is transported by ABCB11ProteinRhea RHEA:50060Inferred only
- glycochenodeoxycholate is transported by ABCC4ProteinRhea RHEA:66408Inferred only
- glycochenodeoxycholate is transported by SLC51AProteinRhea RHEA:71859Inferred only
- glycochenodeoxycholate is transported by SLC51BProteinRhea RHEA:71859Inferred only
- glycochenodeoxycholate is transported by SLCO1A2ProteinRhea RHEA:71859Inferred only
Reactions
10 reactions
glycochenodeoxycholate+3'-phosphoadenylyl sulfateCHEBI:58877+adenosine 3',5'-bisphosphate+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:17689CC BY 4.0Reference data
chenodeoxycholate+glycineglycochenodeoxycholate+water
Reaction pageDirection not assertedBalanced
Rhea RHEA:47112CC BY 4.0Reference data
chenodeoxycholoyl-CoA+glycineglycochenodeoxycholate+coenzyme A(4-)+hydron
Catalysed by BAAT
Reaction pageLeft to rightBalanced
Rhea RHEA:49788CC BY 4.0Reference data
glycochenodeoxycholate+ATP(4-)+waterglycochenodeoxycholate+ADP(3-)+hydrogenphosphate+hydron
Transported by ABCB11
Reaction pageLeft to rightBalanced
Rhea RHEA:50060CC BY 4.0Reference data
glycochenodeoxycholate+NAD(1-)7-oxoglycolithocholate+NADH(2-)+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:53844CC BY 4.0Reference data
glycochenodeoxycholate+NADP(3-)7-oxoglycolithocholate+NADPH(4-)+hydron
Catalysed by HSD11B1
Reaction pageRight to leftBalanced
Rhea RHEA:65056CC BY 4.0Reference data
glycochenodeoxycholate+glutathione+ATP(4-)+waterglycochenodeoxycholate+glutathione+ADP(3-)+hydrogenphosphate+hydron
Transported by ABCC4
Reaction pageLeft to rightBalanced
Rhea RHEA:66408CC BY 4.0Reference data
glycochenodeoxycholateglycochenodeoxycholate
Transported by SLCO1A2 or SLC51A or SLC51B
Reaction pageDirection not assertedBalanced
Rhea RHEA:71859CC BY 4.0Reference data
glycochenodeoxycholate+2sodium(1+)glycochenodeoxycholate+2sodium(1+)
Reaction pageDirection not assertedBalanced
Rhea RHEA:72059CC BY 4.0Reference data
glycochenodeoxycholate+3'-phosphoadenylyl sulfateglycochenodeoxycholate 3-sulfate+adenosine 3',5'-bisphosphate+hydron
Catalysed by SULT2A1
Reaction pageLeft to rightBalanced
Rhea RHEA:85747CC BY 4.0Reference data
Where it reaches
3 systems, 9 regions, 19 tissues, 25 transporter routes — routes, not measurements: transporters known to carry glycochenodeoxycholate are expressed there, and no source reports it arriving.
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Other names
2 names
Resolves to: glycochenodeoxycholate
- Systematic name
- N-(3alpha,7alpha-dihydroxy-5beta-cholan-24-oyl)glycinateN-(3α,7α-dihydroxy-5β-cholan-24-oyl)glycinate