Compound
5-aminolevulinic acid
A compound produced from succinyl-CoA and glycine as an intermediate in heme synthesis. It is used as a photochemotherapy for actinic keratosis.
What it touches on the way
Mechanistic reach
3 entities
3 entities reached.
What the reference databases state
Statements
5 statements
5 statements · 1 reference database · Subject: 5-aminolevulinic acid · Sources: Human-GEM
- 5-aminolevulinic acid is converted to porphobilinogenCompoundHuman-GEM MAR04744Inferred only
- 5-aminolevulinic acid is a substrate of ALADProteinHuman-GEM MAR04744Inferred only
- 5-aminolevulinic acid is transported by SLC15A1ProteinHuman-GEM MAR09985Inferred only
- 5-aminolevulinic acid is transported by SLC15A1ProteinHuman-GEM MAR11307Inferred only
- 5-aminolevulinic acid is transported by SLC36A1ProteinHuman-GEM MAR11307Inferred only
Reactions
7 reactions
MAM00630m+proton5-aminolevulinic acid+carbon dioxide
Catalysed by ALAS1 or ALAS2 or CPNE7
Reaction pageLeft to rightBalancedEC 2.3.1.37GO:0005759
Human-GEM MAR04657CC BY 4.0Reference data
glycine+proton+CHEBI:153805-aminolevulinic acid+carbon dioxide+CHEBI:1146900
Catalysed by ALAS1 or ALAS2 or CPNE7
Reaction pageLeft to rightBalancedEC 2.3.1.37GO:0005759
Human-GEM MAR04742CC BY 4.0Reference data
5-aminolevulinic acid5-aminolevulinic acid
Reaction pageReversibleBalancedGO:0005829, GO:0005759
Human-GEM MAR04743CC BY 4.0Reference data
25-aminolevulinic acidproton+2water+porphobilinogen
Catalysed by ALAD
Reaction pageLeft to rightBalancedEC 4.2.1.24GO:0005829
Human-GEM MAR04744CC BY 4.0Reference data
5-aminolevulinic acid+2proton5-aminolevulinic acid+2proton
Transported by SLC15A1
Reaction pageReversibleBalancedEC 3.1.1.4GO:0005829, GO:0005615
Human-GEM MAR09985CC BY 4.0Reference data
Reaction pageReversibleBalance undeterminableGO:0005615
Human-GEM MAR10428CC BY 4.0Reference data
5-aminolevulinic acid+proton5-aminolevulinic acid+proton
Transported by SLC15A1 or SLC36A1
Reaction pageLeft to rightBalancedGO:0005615, GO:0005829
Human-GEM MAR11307CC BY 4.0Reference data
Where it reaches
1 system, 1 region, 2 tissues, 4 transporter routes — routes, not measurements: transporters known to carry 5-aminolevulinic acid are expressed there, and no source reports it arriving.
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Other names
11 names
Resolves to: 5-aminolevulinic acid
- Also called
- 5-ALA5-Amino-4-oxopentanoate5-Amino-4-oxovaleric acid5-Aminolevulinateaminolevulinic aciddALAdelta-ALAdelta-aminolevulinic acidδ-ALAδ-aminolevulinic acid
- Systematic name
- 5-amino-4-oxopentanoic acid