Compound
itaconate
A dicarboxylic acid dianion that results from the deprotonation of both of the carboxylic acid groups of itaconic acid.
Definition from ChEBI (CHEBI:17240), read 2026-09-23. CC BY 4.0.
Structure
Loading the model…
- Class
- Organic compound, anion
- Formula
- C5H4O4
- Mass
- 128.083 g/mol
- Charge
- -2
- InChIKey
- LVHBHZANLOWSRM-UHFFFAOYSA-L
- SMILES
- C=C(CC(=O)[O-])C(=O)[O-]
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
5 entities
5 entities reached.
0 reported hops5 assembled from the scaffold
- SUCLG2ProteinUNIPROT:Q96I99substrate ofInferred only24 paths12 endpoints
- ABCG2ProteinUNIPROT:Q9UNQ0transported byInferred only14 paths14 endpoints
- SUCLG1ProteinUNIPROT:P53597substrate ofInferred only14 paths7 endpoints
- SUCLA2ProteinUNIPROT:Q9P2R7substrate ofInferred only10 paths5 endpoints
- SLC13A3ProteinUNIPROT:Q8WWT9transported byInferred only3 paths3 endpoints
What the reference databases state
Statements
18 statements
18 statements · 2 reference databases · Subject: itaconate · Sources: Human-GEM, Rhea
- cis-aconitate is converted to itaconateCompoundRhea RHEA:15253Inferred only
- cis-aconitic acid is converted to itaconateCompoundHuman-GEM MAR13087Inferred only
- itaconyl-CoA is converted to itaconateCompoundRhea RHEA:86311Inferred only
- itaconate is converted to itaconyl-CoACompoundRhea RHEA:86307Inferred only
- itaconate is converted to itaconyl-CoACompoundRhea RHEA:86311Inferred only
- itaconyl-CoA is converted to itaconateCompoundRhea RHEA:86307Inferred only
- itaconate is converted to trans-aconitateCompoundRhea RHEA:57728Inferred only
- trans-aconitate is converted to itaconateCompoundRhea RHEA:57728Inferred only
- itaconate is a substrate of SUCLA2ProteinHuman-GEM MAR08663Inferred only
- itaconate is a substrate of SUCLA2ProteinHuman-GEM MAR08662Inferred only
- itaconate is a substrate of SUCLG1ProteinHuman-GEM MAR08662Inferred only
- itaconate is a substrate of SUCLG1ProteinHuman-GEM MAR08663Inferred only
Show the remaining 6
- itaconate is a substrate of SUCLG2ProteinHuman-GEM MAR08663Inferred only
- itaconate is a substrate of SUCLG2ProteinHuman-GEM MAR08662Inferred only
- itaconate is a substrate of SUGCTProteinRhea RHEA:81715Inferred only
- itaconate is a substrate of SUGCTProteinRhea RHEA:38283Inferred only
- itaconate is transported by ABCG2ProteinRhea RHEA:82291Inferred only
- itaconate is transported by SLC13A3ProteinRhea RHEA:82295Inferred only
Reactions
15 reactions
CHEBI:1146900+GTP+itaconateGDP+itaconyl-CoA+phosphate(3-)
Catalysed by SUCLG1 & SUCLG2 or SUCLG1 & SUCLA2
Reaction pageReversibleBalancedEC 6.2.1.5mitochondrial matrix
Human-GEM MAR08662CC BY 4.0Reference data
ADP+itaconyl-CoA+phosphate(3-)ATP+CHEBI:1146900+itaconate
Catalysed by SUCLG1 & SUCLG2 or SUCLG1 & SUCLA2
Reaction pageReversibleBalancedEC 6.2.1.5mitochondrial matrix
Human-GEM MAR08663CC BY 4.0Reference data
Reaction pageReversibleBalancedcytosol, mitochondrial matrix
Human-GEM MAR09174CC BY 4.0Reference data
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR09175CC BY 4.0Reference data
Reaction pageReversibleBalance undeterminableextracellular space
Human-GEM MAR09451CC BY 4.0Reference data
cis-aconitic acid+protoncarbon dioxide+itaconate
Catalysed by ACOD1
Reaction pageLeft to rightBalancedEC 4.1.1.6mitochondrial matrix
Human-GEM MAR13087CC BY 4.0Reference data
cis-aconitate+hydronitaconate+carbon dioxide
Catalysed by ACOD1
Reaction pageLeft to rightBalanced
Rhea RHEA:15253CC BY 4.0Reference data
itaconate+succinyl-CoAitaconyl-CoA+succinate(2-)
Catalysed by SUGCT
Reaction pageReversibleBalanced
Rhea RHEA:38283CC BY 4.0Reference data
trans-aconitate+hydronitaconate+carbon dioxide
Reaction pageDirection not assertedBalanced
Rhea RHEA:57728CC BY 4.0Reference data
itaconate+L-cysteinyl-[protein]S-(2,3-dicarboxypropyl)-L-cysteinyl-[protein]
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:61028CC BY 4.0Reference data
itaconate+glutaryl-CoAitaconyl-CoA+glutarate
Catalysed by SUGCT
Reaction pageReversibleBalanced
Rhea RHEA:81715CC BY 4.0Reference data
itaconate+ATP(4-)+wateritaconate+ADP(3-)+hydrogenphosphate+hydron
Transported by ABCG2
Reaction pageLeft to rightBalanced
Rhea RHEA:82291CC BY 4.0Reference data
Where it reaches
6 systems, 8 regions, 16 tissues, 17 transporter routes — routes, not measurements: transporters known to carry itaconate are expressed there, and no source reports it arriving.
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Other names
5 names
Resolves to: itaconate
- Also called
- methylenesuccinate(2-)methylenesuccinate(2−)methylenesuccinic acid, ion(2-)methylenesuccinic acid, ion(2−)
- Systematic name
- 2-methylidenebutanedioate