Compound
2-methoxyestrone
A 17-oxo steroid that is estrone in which the hydrogen at position 2 has been replaced by a methoxy group.
Definition from ChEBI (CHEBI:1189), read 2026-09-23. CC BY 4.0.
Structure
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- Class
- Organic compound
- Formula
- C19H24O3
- Mass
- 300.398 g/mol
- Charge
- 0
- InChIKey
- WHEUWNKSCXYKBU-QPWUGHHJSA-N
- SMILES
- [H][C@@]12CCC(=O)[C@@]1(C)CC[C@]1([H])c3cc(OC)c(O)cc3CC[C@@]21[H]
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
3 entities
3 entities reached.
What the reference databases state
Chemical structure
- 2-methoxyestrone has the functional parent estroneCompoundChEBI CHEBI:1189Inferred only
Statements
12 statements
12 statements · 2 reference databases · Subject: 2-methoxyestrone · Sources: Human-GEM, Rhea
- 2-hydroxyestrone is converted to 2-methoxyestroneCompoundRhea RHEA:53100Inferred only
- 2-methoxyestrone is converted to 2-hydroxyestroneCompoundHuman-GEM MAR02058Inferred only
- 2-methoxyestrone is converted to 2-hydroxyestroneCompoundHuman-GEM MAR02059Inferred only
- 2-hydroxyestrone is converted to 2-methoxyestroneCompoundHuman-GEM MAR02058Inferred only
- 2-hydroxyestrone is converted to 2-methoxyestroneCompoundHuman-GEM MAR02059Inferred only
- 2-methoxyestrone is converted to 2-methoxyestrone 3-O-(beta-D-glucuronate)CompoundRhea RHEA:53064Inferred only
- 2-methoxyestrone is metabolised by COMTProteinHuman-GEM MAR02058Inferred only
- 2-methoxyestrone is metabolised by COMTProteinHuman-GEM MAR02059Inferred only
- 2-methoxyestrone is metabolised by UGT1A8ProteinRhea RHEA:53064Inferred only
- 2-methoxyestrone is a substrate of LRTOMTProteinHuman-GEM MAR02058Inferred only
- 2-methoxyestrone is a substrate of LRTOMTProteinHuman-GEM MAR02059Inferred only
- 2-methoxyestrone is transported by ABCB1ProteinHuman-GEM MAR11763Inferred only
Reactions
7 reactions
16alpha-hydroxyestrone+16alpha-hydroxyestrone+MAM00432r+MAM00604c+MAM00624c+MAM00641c+MAM00641m+MAM00641r+MAM00641x+MAM00642c+MAM00642m+MAM00642r+MAM00642x+MAM00644c+MAM00645c+2-hydroxy-17beta-estradiol+2-hydroxy-17beta-estradiol+MAM00651c+MAM00651m+MAM00651r+MAM00651x+MAM00652c+MAM00652m+MAM00652r+MAM00652x+2-methoxy-17beta-estradiol+2-methoxyestrone+2-methoxyestrone+MAM00747r+MAM00828r+MAM00830c+MAM00925c+MAM00927c+MAM00945c+MAM00947c+MAM00949c+MAM00987c+MAM00987m+MAM00987r+MAM00987x+(E)-4-hydroxynon-2-enal+MAM01001c+MAM01001m+MAM01001r+MAM01001x+MAM01011c+4-methoxyestrone+3alpha-hydroxy-5alpha-pregnan-20-one+MAM01792r+MAM01794r+MAM02469cMAM10001e
Reaction pageLeft to rightBalance undeterminablecytosol, endoplasmic reticulum, mitochondrial matrix, peroxisome, lysosome, extracellular space
Human-GEM MAR00037CC BY 4.0Reference data
2-hydroxyestrone+S-adenosyl-L-methionine2-methoxyestrone+proton+CHEBI:16680
Reaction pageReversibleBalancedEC 2.1.1.6cytosol
Human-GEM MAR02058CC BY 4.0Reference data
2-hydroxyestrone+S-adenosyl-L-methionine2-methoxyestrone+proton+CHEBI:16680
Reaction pageReversibleBalancedEC 2.1.1.6endoplasmic reticulum
Human-GEM MAR02059CC BY 4.0Reference data
2-methoxyestrone+ATP+water2-methoxyestrone+ADP+proton+phosphate(3-)
Transported by ABCB1
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR11763CC BY 4.0Reference data
Reaction pageReversibleBalance undeterminableextracellular space
Human-GEM MAR11862CC BY 4.0Reference data
2-methoxyestrone+UDP-alpha-D-glucuronate2-methoxyestrone 3-O-(beta-D-glucuronate)+UDP+hydron
Catalysed by UGT1A8
Reaction pageLeft to rightBalanced
Rhea RHEA:53064CC BY 4.0Reference data
2-hydroxyestrone+S-adenosyl-L-methionine2-methoxyestrone+S-adenosyl-L-homocysteine+hydron
Catalysed by COMT
Reaction pageLeft to rightBalanced
Rhea RHEA:53100CC BY 4.0Reference data
Where it reaches
3 systems, 6 regions, 11 tissues, 11 transporter routes — routes, not measurements: transporters known to carry 2-methoxyestrone are expressed there, and no source reports it arriving.
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Other names
3 names
Resolves to: 2-methoxyestrone
- Also called
- 2-methoxy,3-hydroxy-estra-1,3,5(10)-trien-17-oneST 19:4;O3
- Systematic name
- 3=hydroxy-2-methoxyestra-1,3,5(10)-trien-17-one